Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC16310FTI 277 HClCAS: 180977-34-8纯度: >99.00%
FTI 277 HCl是一种强效且具有选择性的法尼基转移酶（FTase）抑制剂，IC 50 值为0.5nM，较香叶酰基香叶转移酶I（GGTase I）选择性高出约100倍。
- GC16319FebuxostatCAS: 144060-53-7纯度: >99.50%
An inhibitor of the oxidized and reduced forms of xanthine oxidase
- GC16375(±)-Jasmonic Acid methyl esterCAS: 39924-52-2纯度: >98.00%
(±)-Jasmonic Acid methyl ester是一种重要的天然植物信号分子和植物激素，具备多种生物学活性。
- GC16438L-Histidinol (hydrochloride)CAS: 1596-64-1纯度: >95.00%
An intermediate in L-histidine biosynthesis
- GC16724Sivelestat (ONO-5046)CAS: 127373-66-4纯度: >98.00%
Sivelestat (ONO-5046) (EI546) 是人中性粒细胞弹性蛋白酶的竞争性抑制剂，IC50 为 44 nM，Ki 为 200 nM。 Sivelestat (ONO-5046) (EI546) 具有研究 COVID-19 中急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的潜力。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC16296 | MI-773 | 1303607-07-9 | >98.00% | |
MI-773 是一种有效的 MDM2-p53 蛋白-蛋白相互作用 (PPI) 抑制剂，对 MDM2 具有高结合亲和力 (Kd=8.2 nM)。 MI-773 具有抗肿瘤活性。 | ||||
| GC16307 | Lisinopril | 76547-98-3 | - | |
An ACE inhibitor | ||||
| GC16310 | FTI 277 HCl | 180977-34-8 | >99.00% | |
FTI 277 HCl是一种强效且具有选择性的法尼基转移酶（FTase）抑制剂，IC 50 值为0.5nM，较香叶酰基香叶转移酶I（GGTase I）选择性高出约100倍。 | ||||
| GC16319 | Febuxostat | 144060-53-7 | >99.50% | |
An inhibitor of the oxidized and reduced forms of xanthine oxidase | ||||
| GC16333 | Cycloguanil (hydrochloride) | 152-53-4 | >99.50% | |
The active metabolite of proguanil | ||||
| GC16350 | Actinonin | 13434-13-4 | >99.00% | |
Actinonin是一种肽模拟抗生素，能够抑制enkephalin-aminopeptidase、enkephalinase A和 dipeptidylaminopeptidase，IC 50 值分别为0.39μM、5.6μM和1.1μM。 | ||||
| GC16368 | Indole-3-carbinol | 700-06-1 | >98.00% | |
A natural phytochemical | ||||
| GC16371 | Solasodine | 126-17-0 | >98.00% | |
An alkaloid with diverse biological activities | ||||
| GC16375 | (±)-Jasmonic Acid methyl ester | 39924-52-2 | >98.00% | |
(±)-Jasmonic Acid methyl ester是一种重要的天然植物信号分子和植物激素，具备多种生物学活性。 | ||||
| GC16383 | Calpain Inhibitor II, ALLM | 136632-32-1 | - | |
Calpain inhibitor | ||||
| GC16403 | 2-Arachidonoyl Glycerol | 53847-30-6 | >95.00% | |
Endogenous CB 1 and CB 2 receptor agonist | ||||
| GC16438 | L-Histidinol (hydrochloride) | 1596-64-1 | >95.00% | |
An intermediate in L-histidine biosynthesis | ||||
| GC16443 | 4-Aminohippuric Acid | 61-78-9 | >98.00% | |
A substrate for OAT1, NPT1, and MDR2 | ||||
| GC16449 | Cellobiose | 528-50-7 | >99.00% | |
A disaccharide | ||||
| GC16471 | Y-29794 oxalate | 146794-84-5 | - | |
Inhibitor of prolyl endopeptidase | ||||
| GC16505 | E-64-c | 76684-89-4 | >99.50% | |
An active metabolite of E-64d | ||||
| GC16508 | Salicylic acid | 69-72-7 | >98.00% | |
An Analytical Reference Standard | ||||
| GC16536 | Phenyl sulfate | 937-34-8 | >99.50% | |
| GC16553 | N-Desmethylclozapine | 6104-71-8 | >99.50% | |
An active metabolite of clozapine | ||||
| GC16577 | SB-3CT | 292605-14-2 | >99.00% | |
A selective inhibitor of MMP-2 and MMP-9 | ||||
| GC16597 | Alda 1 | 349438-38-6 | >99.50% | |
Alda 1是一种醛脱氢酶2（ALDH2）激活剂。 | ||||
| GC16613 | Trelagliptin | 865759-25-7 | >99.50% | |
A DDP-4 inhibitor | ||||
| GC16724 | Sivelestat (ONO-5046) | 127373-66-4 | >98.00% | |
Sivelestat (ONO-5046) (EI546) 是人中性粒细胞弹性蛋白酶的竞争性抑制剂，IC50 为 44 nM，Ki 为 200 nM。 Sivelestat (ONO-5046) (EI546) 具有研究 COVID-19 中急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的潜力。 | ||||
| GC16733 | Vildagliptin (LAF-237) | 274901-16-5 | >98.00% | |
A DPP-4 inhibitor | ||||