(±)-Jasmonic Acid methyl ester is an important natural plant signaling molecule and phytohormone that possesses diverse biological activities. (±)-Jasmonic Acid methyl ester is used in research related to cancer, inflammatory responses, and other areas[1-4].
In vitro, (±)-Jasmonic Acid methyl ester (1-2mM) was used to treat the human neuroblastoma cell lines SK-N-SH and BE(2)-C for 6-24h. (±)-Jasmonic Acid methyl ester significantly inhibited cell viability and downregulated the expression of proliferating cell nuclear antigen (PCNA), while inducing apoptosis and downregulating the expression of X-linked inhibitor of apoptosis protein (XIAP) and survivin[5]. (±)-Jasmonic Acid methyl ester (0.5-2.0mM) was used to treat the human prostate adenocarcinoma cell line PC-3 exposed to 7.6Gy γ-radiation for 24 hours. (±)-Jasmonic Acid methyl ester significantly suppressed the expression of the anti-apoptotic protein Bcl-2, induced apoptosis, and enhanced caspase-3 activity[6].
In vivo, (±)-Jasmonic Acid methyl ester (60mg/kg; once daily) was administered intraperitoneally to female BALB/c mice bearing 4T1 breast cancer for 10 days. (±)-Jasmonic Acid methyl ester inhibited tumor growth and caused grade 1 hepatotoxicity[7]. (±)-Jasmonic Acid methyl ester (5-20mg/kg) was administered intraperitoneally to male Swiss mice treated with intraperitoneal LPS (830μg/kg) for 7 days. (±)-Jasmonic Acid methyl ester significantly reduced LPS-induced depressive-like behaviors, reversed anhedonia, and decreased corticosterone, TNF-α levels, and oxidative stress[8].
References:
[1] Li H, Lv L, Wu C, et al. Methyl Jasmonate Protects Microglial Cells Against β-Amyloid-Induced Oxidative Stress and Inflammation via Nrf2-Dependent HO-1 Pathway. Neuropsychiatr Dis Treat. 2020 Jun 4;16:1399-1410.
[3] Zhang M, Zhang MW, Zhang L, et al. Methyl jasmonate and its potential in cancer therapy. Plant Signal Behav. 2015;10(9):e1062199.
[4] Yang DK, Tungalag T, Lee SJ, et al. Methyl Jasmonate-induced Increase in Intracellular Magnesium Promotes Apoptosis in Breast Cancer Cells. Anticancer Res. 2024 Mar;44(3):1087-1095.
[5] Tong QS, Jiang GS, Zheng LD, et al. Methyl jasmonate downregulates expression of proliferating cell nuclear antigen and induces apoptosis in human neuroblastoma cell lines. Anticancer Drugs. 2008 Jul;19(6):573-81.
[6] Ezekwudo D, Shashidharamurthy R, Devineni D, et al. Inhibition of expression of anti-apoptotic protein Bcl-2 and induction of cell death in radioresistant human prostate adenocarcinoma cell line (PC-3) by methyl jasmonate. Cancer Lett. 2008 Nov 8;270(2):277-85.
[7] Yousefi S, Darvishi P, Yousefi Z, et al. Effect of methyl jasmonate and 3-bromopyruvate combination therapy on mice bearing the 4 T1 breast cancer cell line. J Bioenerg Biomembr. 2020 Apr;52(2):103-111.
[8] Adebesin A, Adeoluwa OA, Eduviere AT, et al. Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice. J Psychiatr Res. 2017 Nov;94:29-35.
(±)-Jasmonic Acid methyl ester是一种重要的天然植物信号分子和植物激素，具备多种生物学活性。(±)-Jasmonic Acid methyl ester用与癌症、炎症反应等相关研究[1-4]。
在体外，(±)-Jasmonic Acid methyl ester（1-2mM）处理人类神经母细胞瘤细胞系SK-N-SH和BE(2)-C 6-24小时。(±)-Jasmonic Acid methyl ester显著抑制细胞活力并下调增殖细胞核抗原（PCNA）的表达，同时诱导细胞凋亡并下调X连锁凋亡抑制蛋白（XIAP）和生存素（survivin）的表达[5]。(±)-Jasmonic Acid methyl ester（0.5-2.0mM）处理经7.6Gy γ-辐射照射的人前列腺腺癌细胞系PC-3 24小时。(±)-Jasmonic Acid methyl ester显著抑制抗凋亡蛋白Bcl-2的表达，同时诱导细胞凋亡并增强caspase-3活性[6]。
在体内，(±)-Jasmonic Acid methyl ester（60mg/kg；每日一次）腹腔注射于携带4T1乳腺癌的BALB/c雌性小鼠10天。(±)-Jasmonic Acid methyl ester可抑制肿瘤生长，同时引起1级肝毒性[7]。(±)-Jasmonic Acid methyl ester（5-20mg/kg）腹腔注射于处理腹腔注射LPS（830μg/kg）的雄性瑞士小鼠，连续7天。(±)-Jasmonic Acid methyl ester显著减少了LPS诱导的抑郁样行为，逆转了快感缺失，并降低了皮质酮、TNF-α水平和氧化应激[8]。