CP-28888 is an interferon inducer, more potent in mice, but is less active in man and devoid of antirhinovirus effects.
CP-28,888-27 appears to be a more potent interferon inducer than CP-20,961 in experiments using comparable methods in animal systems. In CP-28,888-27 (25 mg/kg, i.p.)-treated mice, plasma interferon levels of CP-28,888-27 are 10-fold higher than CP-20,961[1].
[1]. Douglas RG Jr, et al. Lack of effect of an interferon inducer, N,N-dihexadecyl-m-xylylenediamine, on rhinovirus challenge in humans. Antimicrob Agents Chemother. 1979 Feb;15(2):269-72.