3-chloro-L-Tyrosine is a derivative of L-tyrosine.1 It is formed from a reaction between the myeloperoxidase (MPO) product hypochlorous acid and L-tyrosine and has been used as a biomarker of oxidative damage induced by MPO. Plasma and atherosclerotic plaque levels of 3-chloro-L-tyrosine are increased in patients with various cardiovascular diseases.2 Plasma levels of 3-chloro-L-tyrosine are also increased in patients with colorectal cancer. 3-chloro-L-Tyrosine is also formed in blood upon chlorine gas exposure and has been used as an indicator of chlorine poisoning during autopsy.3
1.Feeney, M.B., and Sch?neich, C.Tyrosine modifications in agingAntioxid. Redox Signal.17(11)1571-1579(2012) 2.Fleszar, M.G., Fortuna, P., Zawadzki, M., et al.Simultaneous LC-MS/MS-based quantification of free 3-nitro-l-tyrosine, 3-chloro-l-tyrosine, and 3-bromo-l-tyrosine in plasma of colorectal cancer patients during early postoperative periodMolecules25(21)5158(2020) 3.Nishio, T., Toukairin, Y., Hoshi, T., et al.Determination of 3-chloro-l-tyrosine as a novel indicator of chlorine poisoning utilizing gas chromatography-mass spectrometric analysisLeg. Med. (Tokyo)47101782(2020)