GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC15994 structure
    GC15994Pyridoxal hydrochloride
    CAS: 65-22-5
    纯度: >99.50%

    A transport form of vitamin B 6

  • GC15998 structure
    GC15998LX-1031
    CAS: 945976-76-1
    纯度: >99.50%

    LX-1031 是一种有效的、可口服的色氨酸 5-羟化酶 (TPH) 抑制剂，可减少外周血清素 (5-HT) 的合成。

  • GC16014 structure
    GC16014Zileuton
    CAS: 111406-87-2
    纯度: >99.00%

    Zileuton是一种苯并噻吩N-羟基脲类化合物，作为口服5-脂氧合酶抑制剂。

  • GC16051 structure
    GC16051Nutlin-3
    CAS: 890090-75-2
    纯度: >99.00% / >98.00%

    A racemic mixture of (?)-nutlin-3 and (+)-nutlin-3

  • GC16055 structure
    GC16055SMIP004
    CAS: 143360-00-3
    纯度: >98.50%

    SMIP004 是一种 SKP2 E3 连接酶抑制剂，可下调 SKP2 并稳定 p27。 SMIP004 是人前列腺癌细胞的癌细胞选择性凋亡诱导剂。

  • GC16066 structure
    GC16066Calcifediol
    CAS: 19356-17-3
    纯度: >99.50% / >98.00%

    A vitamin D intermediate

  • GC16079 structure
    GC16079Deoxyarbutin
    CAS: 53936-56-4
    纯度: >98.00%

    A tyrosinase inhibitor

  • GC16098 structure
    GC16098MK-5172 hydrate
    CAS: 1350462-55-3
    纯度: >99.00%

    MK-5172 hydrate (MK-5172 hydrate) 是丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂，对基因型和耐药变体具有广泛的活性，Kis 为 0.01 nM (gt1b)、0.01 nM (gt1a)、0.08 nM (gt2a) )、0.15 nM (gt2b)、0.90 nM (gt3a)。

  • GC16103 structure
    GC16103Oleylethanolamide
    CAS: 111-58-0
    纯度: >90.00%

    An endogenous, potent agonist for PPARα

  • GC16127 structure
    GC16127Topiroxostat
    CAS: 577778-58-6
    纯度: >98.00%

    An inhibitor of xanthine oxidoreductase

  • GC16133 structure
    GC16133DGAT-1 inhibitor
    CAS: 701232-20-4
    纯度: >98.00%

    A DGAT-1 inhibitor

  • GC16138 structure
    GC16138AHU-377 hemicalcium salt
    CAS: 1369773-39-6
    纯度: >99.50%

    A prodrug form of LBQ657

  • GC16165 structure
    GC16165T-5224
    CAS: 530141-72-1
    纯度: >98.00%

    T-5224 是一种非肽类小分子 AP-1 抑制剂，特异性抑制 AP-1 与启动子区 AP-1 结合位点的结合，最初开发为抗炎药用于治疗类风湿性关节炎 (RA) 抑制炎症细胞因子和 MMPs 而没有任何副作用。

  • GC16181 structure
    GC16181Cathepsin Inhibitor 1
    CAS: 225120-65-0
    纯度: >98.00%

    Cathepsin inhibitor 1 (compound 25) 是一种有效的选择性 Cathepsin 抑制剂，对 CatL、CatL2、CatS、CatK 和 CatB 的 pIC50 分别为 7.9、6.7、6.0、5.5 和 5.2。

  • GC16192 structure
    GC16192Diminazene Aceturate
    CAS: 908-54-3
    纯度: >99.00%

    An anti-protozoal diamidine

  • GC16197 structure
    GC16197RO4929097
    CAS: 847925-91-1
    纯度: >98.00%

    An inhibitor of γ-secretase

  • GC16200 structure
    GC16200L-Biopterin
    CAS: 22150-76-1
    纯度: >99.50%

    An intermediate for tetrahydro-L-biopterin

  • GC16205 structure
    GC16205D-Sorbitol
    CAS: 98201-93-5
    纯度: >98.00%

    D-山梨醇（Sorbitol）是一种六碳糖醇，可用作糖的替代品。

  • GC16215 structure
    GC16215GSK744 (S/GSK1265744)
    CAS: 1051375-10-0
    纯度: >98.00%

    An HIV-1 integrase inhibitor

  • GC16223 structure
    GC16223Captopril
    CAS: 62571-86-2
    纯度: >99.00%

    Captopril是一种具有口服活性的血管紧张素转化酶（ACE）抑制剂，IC 50 值为0.025μM。

  • GC16257 structure
    GC16257AZD 3988
    CAS: 892489-52-0
    纯度: >98.00%

    AZD 3988 是一种具有口服活性的 diacylglycerol acyl transferase-1 (DGAT-1) 抑制剂。

  • GC16279 structure
    GC16279Telotristat
    CAS: 1033805-28-5

    A TPH1 inhibitor

  • GC16290 structure
    GC16290Nafamostat hydrochloride
    CAS: 80251-32-7

    Nafamostat hydrochloride 是一种合成丝氨酸蛋白酶抑制剂，是一种抗凝剂。

  • GC16292 structure
    GC16292Equol
    CAS: 94105-90-5
    纯度: >98.00%

    An estrogen receptor agonist