GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC15442 structure
    GC15442Tipifarnib (Zarnestra)
    CAS: 192185-72-1
    纯度: >98.50%

    A farnesyltransferase inhibitor with antitumor activity

  • GC15457 structure
    GC15457Pyridoxine
    CAS: 65-23-6
    纯度: >98.00% / >99.50%

    A 4-methanol form of vitamin B 6

  • GC15502 structure
    GC15502Gluconate sodium
    CAS: 527-07-1
    纯度: >98.00%

    葡萄糖酸钠（D-葡萄糖酸钠盐）是普通钢在模拟冷却水中的缓蚀阻垢剂。

  • GC15509 structure
    GC15509Uracil
    CAS: 66-22-8
    纯度: >98.00%

    A pyrimidine nucleoside

  • GC15576 structure
    GC15576Teneligliptin hydrobromide
    CAS: 906093-29-6
    纯度: >99.50%

    A DPP-4 inhibitor

  • GC15601 structure
    GC15601AG-120
    CAS: 1448347-49-6
    纯度: >99.50% / >98.00%

    AG-120 (Ivosidenib)是一种突变型异柠檬酸脱氢酶1（mIDH1）抑制剂。

  • GC15614 structure
    GC15614A922500
    CAS: 959122-11-3
    纯度: >98.50%

    A922500是一种有效、选择性高且具有口服活性的二酰基甘油酰基转移酶1（DGAT-1）抑制剂，对人源和小鼠DGAT-1的IC 50 值分别为9和22nM。

  • GC15618 structure
    GC15618Melatonin
    CAS: 73-31-4
    纯度: >99.00% / >98.50%

    An indoleamine neurohormone that entrains circadian rhythms

  • GC15649 structure
    GC15649Substance P
    CAS: 33507-63-0
    纯度: >99.00%

    Substance P作为一种重要的神经肽类神经递质，能够刺激磷脂酰肌醇代谢，EC 50 值为0.36nM。

  • GC15682 structure
    GC15682Chymostatin
    CAS: 9076-44-2
    纯度: >95.00%

    Chymostatin是一种选择性强的蛋白酶体糜蛋白酶样活性抑制剂，Chymostatin对胰凝乳蛋白酶和凝乳酶的Ki分别为9.36nM和13.1nM。

  • GC15708 structure
    GC15708Cysteine Protease inhibitor hydrochloride
    CAS: 2197053-49-7

    Cysteine Protease inhibitor hydrochloride 是半胱氨酸蛋白酶的抑制剂。

  • GC15726 structure
    GC15726NNGH
    CAS: 161314-17-6
    纯度: ≥99.00%

    A broad-spectrum MMP inhibitor

  • GC15755 structure
    GC15755Ribitol
    CAS: 488-81-3
    纯度: >98.00%

    A pentose sugar alcohol

  • GC15764 structure
    GC15764Cilastatin sodium
    CAS: 81129-83-1
    纯度: >97.00%

    An inhibitor of dipeptidase (dehydropeptidase I)

  • GC15770 structure
    GC15770Atglistatin
    CAS: 1469924-27-3
    纯度: >98.00%

    Atglistatin是一种选择性脂肪甘油三酯脂肪酶（ATGL）抑制剂（IC 50 = 0.7μM）。

  • GC15771 structure
    GC15771PYR-41
    CAS: 418805-02-4
    纯度: >98.00%

    PYR-41是一种不可逆的、细胞渗透性的泛素激活酶E1抑制剂，IC 50 值小于10μM，对E2和E3基本无作用。

  • GC15800 structure
    GC15800GGACK Dihydrochloride

    尿激酶/VIIa/Ixa/Xa/胰蛋白酶抑制剂

  • GC15815 structure
    GC15815Thymidine
    CAS: 50-89-5
    纯度: >99.50% / >98.00%

    A pyrimidine nucleoside

  • GC15828 structure
    GC15828AMG232
    CAS: 1352066-68-2
    纯度: >98.00%

    An inhibitor of the MDM2 and p53 interaction

  • GC15880 structure
    GC15880Penicillic Acid
    CAS: 90-65-3
    纯度: >99.50% / >98.00%

    A mycotoxin that inhibits quorum sensing

  • GC15896 structure
    GC15896Z-Ile-Leu-aldehyde
    CAS: 161710-10-7
    纯度: >98.00%

    Z-Ile-Leu-aldehyde (Z-IL-CHO) 是一种有效的、竞争性的 γ-分泌酶和缺口肽醛抑制剂。

  • GC15948 structure
    GC15948Prostaglandin E2
    CAS: 363-24-6
    纯度: >98.00%

    Prostaglandin E2是花生四烯酸在环氧合酶(COX)催化下产生的主要代谢物。

  • GC15975 structure
    GC15975α-Estradiol
    CAS: 57-91-0
    纯度: >99.50% / >98.00%

    A weak estrogen with neuroprotective effects

  • GC15993 structure
    GC15993Lauric Acid
    CAS: 143-07-7
    纯度: >98.00%

    A medium-chain fatty acid