L-SelenoMethionine is a selenoamino acid, which is a natural component of the diet and has been estimated to account for at least half of all dietary selenium[1]. L-SelenoMethionine has been widely used as a feed additive for various animals[2]. L-SelenoMethionine has been widely used as a cell viability regulator under oxidative stress conditions[3].
In vitro, L-SelenoMethionine treatment (40µg/ml; 48h) can alleviate the oxidative damage of pulmonary artery smooth muscle cells (PASMCs) under hypoxic conditions and inhibit the proliferation of PASMCs[4]. After treating human thyroid epithelial cells with 5μM L-SelenoMethionine for 24 hours, the radiation effect can be reduced by alleviating stress-related signaling pathways and down-regulating certain genes related to cell adhesion[5]. Treatment with 65μM L-SelenoMethionine for 24 hours significantly inhibited the growth of A549 cells and induced cell apoptosis[6].
In vivo, L-SelenoMethionine treatment (p.o.) at the dose of 12g/g/day for 3 days significantly protected Sprague-Dawley rats from oxidative stress damage induced by space radiation[7]. Oral administration of 0.5mg/kg/day dose of L-SelenoMethionine for one month can effectively alleviate intestinal damage and ferroptosis in sows caused by ammonia exposure[8].
References:
[1] Aguilar F, Charrondiere U R, Dusemund B, et al. L-selenomethionine as a source of selenium added for nutritional purposes to food supplements[J]. EFSA JOURNAL, 2009, 1082: 1-38.
[2] EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). Scientific Opinion on the safety and efficacy of L‐selenomethionine as feed additive for all animal species[J]. EFSA Journal, 2013, 11(5): 3219.
[3] Sun H, Zhang M, Li J, et al. DL-Selenomethionine alleviates oxidative stress induced by zearalenone via Nrf2/Keap1 signaling pathway in IPEC-J2 cells[J]. Toxins, 2021, 13(8): 557.
[4] Huang T, Liu S, Ma Y, et al. Selenomethionine inhibits the proliferation of hypoxia-induced pulmonary artery smooth muscle cells by inhibiting ROS and HIF-1α-ACE-AngII axis[J]. Scientific Reports, 2025, 15(1): 11746.
[5] Nuth M, Kennedy A R. Mitigating effects of L‑selenomethionine on low‑dose iron ion radiation‑induced changes in gene expression associated with cellular stress[J]. Oncology letters, 2013, 6(1): 35-42.
[6] Redman C, Xu M J, Peng Y M, et al. Involvement of polyamines in selenomethionine induced apoptosis and mitotic alterations in human tumor cells[J]. Carcinogenesis, 1997, 18(6): 1195-1202.
[7] Guan J, Wan X S, Zhou Z, et al. Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley rats[J]. Radiation research, 2004, 162(5): 572-579.
[8] Zhang X, Wang A, Chen Y, et al. Intestinal barrier dysfunction induced by ammonia exposure in pigs in vivo and in vitro: The protective role of L-selenomethionine[J]. Ecotoxicology and Environmental Safety, 2022, 248: 114325.
L-SelenoMethionine是一种硒氨基酸，作为膳食中的天然成分，约占日常硒摄入量的50%以上[1]。L-SelenoMethionine广泛用作多种动物的饲料添加剂[2]。L-SelenoMethionine在氧化应激条件下作为细胞活力调节剂使用[3]。
在体外，40µg/ml浓度的L-SelenoMethionine处理48小时可缓解缺氧条件下肺动脉平滑肌细胞(PASMCs)的氧化损伤，并抑制细胞增殖[4]。5μM浓度的L-SelenoMethionine处理人甲状腺上皮细胞24小时能通过减轻应激相关信号通路和下调细胞黏附相关基因，降低辐射损伤[5]。65μM浓度的L-SelenoMethionine处理24小时可显著抑制A549细胞生长并诱导细胞凋亡[6]。
在体内，以12μg/g/day的剂量口服L-SelenoMethionine处理3天，能显著保护Sprague-Dawley大鼠免受空间辐射诱导的氧化应激损伤[7]。以0.5mg/kg/day的剂量口服L-SelenoMethionine 处理1个月，可有效缓解氨暴露导致的母猪肠道损伤和铁死亡[8]。