Cholesteryl oleate是动脉粥样硬化斑块中含量最丰富的脂质之一，与动脉粥样硬化的进展相关。
Cas No.:303-43-5
Sample solution is provided at 25 µL, 10mM.
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Cholesteryl oleate is one of the most abundant lipids in the atherosclerotic plaque, which is associated with the progression of atherosclerosis [1]. Cholesteryl oleate can penetrate into the clusters composed of oleic acid dimers and decrease the rotational movements of oleic acid [2]. Cholesteryl oleate is widely used as an arterial atherosclerosis lesion model to verify the removal effect of 5.75μm free electron laser irradiation [3]. Cholesteryl oleate accumulates in prostate cancer and is significantly correlated with cancer progression, is employed as the diagnostic biomarker for prostate cancer[4]. Cholesteryl oleate has been widely used in low-toxicity cationic solid lipid nanoparticles to achieve safe and effective non-viral nucleic acid delivery[5].
References:
[1] Lee E S, Shon H K, Lee T G, et al. The regional ratio of cholesteryl palmitate to cholesteryl oleate measured by ToF-SIMS as a key parameter of atherosclerosis[J]. Atherosclerosis, 2013, 226(2): 378-384.
[2] Iwahashi M, Umehara A, Wakisaka K, et al. Effect of cholesterol and other additives on viscosity, self-diffusion coefficient, and intramolecular movements of oleic acid[J]. The Journal of Physical Chemistry B, 2007, 111(4): 740-747.
[3] Awazu K, Fukami Y. Selective removal of cholesteryl oleate through collagen films by MIR FEL[J]. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2001, 475(1-3): 650-655.
[4] Li J, Ren S, Piao H, et al. Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer[J]. Scientific reports, 2016, 6(1): 20984.
[5] Suñé-Pou M, Prieto-Sánchez S, El Yousfi Y, et al. Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy[J]. International journal of nanomedicine, 2018: 3223-3233.
Cholesteryl oleate是动脉粥样硬化斑块中含量最丰富的脂质之一，与动脉粥样硬化的进展相关[1]。Cholesteryl oleate能渗透进入由油酸二聚体组成的簇中，并降低油酸的旋转运动[2]。Cholesteryl oleate被广泛用作动脉粥样硬化病变模型，以验证5.75μm自由电子激光照射的清除效果[3]。Cholesteryl oleate在前列腺癌中积累，并与癌症进展显著相关，被用作前列腺癌的诊断生物标志物[4]。Cholesteryl oleate已被广泛用于低毒阳离子固体脂质纳米颗粒中，以实现安全有效的非病毒核酸递送[5]。
| Cas No. | 303-43-5 | SDF | |
| 别名 | 胆固醇油酸酯 | ||
| Canonical SMILES | CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C | ||
| 分子式 | C45H78O2 | 分子量 | 651.1 |
| 溶解度 | DMS : 5.2 mg/mL (7.99 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.5359 mL | 7.6793 mL | 15.3586 mL |
| 5 mM | 307.2 μL | 1.5359 mL | 3.0717 mL |
| 10 mM | 153.6 μL | 767.9 μL | 1.5359 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet