Dinoprost (Prostaglandin F2a) is an orally active, potent prostaglandin receptor (FP receptor) agonist.Dinoprost stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action[1].
Dinoprost (1μM; 24h) induces ER stress, autophagy, and apoptosis in goat luteal cells[2]. Dinoprost (1μg/mL; 24h) stimulated P4 secretion, luprostiol did not in uence P4 synthesis. The cytotoxic and pro-apoptotic effects were observed in the Dinoprost-treated cells[3].
After confirming that the corpus luteum is mature in the ewe, Dinoprost (12.5 mg; im) is injected. Half an hour later, the blood flow velocity of the ewe increases, and one hour later, the NO level rises rapidly, which has a negative impact on the corpus luteum[4]. In rats treated with Dinoprost (6mg/kg; sc; 3d) after ovarian I/R injury, the expression of COX-2 was reduced, the expression of IL-1β and TNF-α did not change significantly, and the amount of bleeding was reduced [5].
References:
[1].Wen X, Liu L, Li S, et al. Prostaglandin F2α induces goat corpus luteum regression via endoplasmic reticulum stress and autophagy[J]. Frontiers in Physiology, 2020, 11: 868.
[2].Thieme H, Schimmat C, Münzer G, et al. Endothelin antagonism: effects of FP receptor agonists prostaglandin F2α and fluprostenol on trabecular meshwork contractility[J]. Investigative ophthalmology & visual science, 2006, 47(3): 938-945.
[3]. Korzekwa A J, Lukasik K, Pilawski W, et al. Influence of prostaglandin F2α analogues on the secretory function of bovine luteal cells and ovarian arterial contractility in vitro[J]. The Veterinary Journal, 2014, 199(1): 131-137.
[4].El-Sherry T M, Senosy W, Mahmoud G B, et al. Effect of dinoprost and cloprostenol on serum nitric oxide and corpus luteum blood flow during luteolysis in ewes[J]. Theriogenology, 2013, 80(5): 513-518.
[5].Karakus S, Ozkaraca M. Investigating the protective potential of dinoprost in a rat model of ischemia-reperfusion[J]. 2023.
Dinoprost (Prostaglandin F2a)是一种口服有效的强效前列腺素受体 （FP 受体） 激动剂。Dinoprost刺激子宫肌层活动，放松宫颈，抑制黄体类固醇生成，并通过直接作用诱导黄体溶解[1]。
Dinoprost（1 μM；24 h）诱导山羊黄体细胞中的 ER 应激、自噬和细胞凋亡[2]。Dinoprost（1μg/mL；24 h）刺激 P4 分泌，在用Dinoprost处理的细胞中观察到细胞毒性和促细胞凋亡作用[3]。
确认母羊体内黄体成熟后，注射Dinoprost（12.5mg；im），半小时后母羊血流速度加快，1小时后NO水平迅速升高，对黄体产生负面影响[4]。大鼠卵巢I/R损伤后经Dinoprost（6mg/kg；sc；3d）治疗，大鼠COX-2表达降低，IL-1β和TNF-α表达无明显变化，出血量减少[5]。