2-Hydroxyadipic acid is a dicarboxylic fatty acid. Levels of 2-hydroxyadipic acid are decreased in tumor tissue from patients with esophageal squamous cell carcinoma.1 Urinary 2-hydroxyadipic acid levels are increased in patients with 2-ketoadipic aciduria, a disorder characterized by a deficiency in lysine, hydroxylysine, and tryptophan degradation.2
1.Chen, Z., Gao, Y., Huang, X., et al.Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinomaJ. Pharm. Biomed. Anal.197113937(2021) 2.Stiles, A.R., Venturoni, L., Mucci, G., et al.New cases of DHTKD1 mutations in patients with 2-ketoadipic aciduriaJIMD Reports. Volume 252515-19(2015)