1-Methylhistamine is a major metabolite produced by the methylation of histamine catalyzed by histamine N-methyltransferase (HNMT), used to assess the metabolic level of histamine in the body[1]. As the primary inactivation product of histamine in the central nervous system and peripheral tissues, 1-Methylhistamine concentration (particularly in cerebrospinal fluid and urine) can serve as a biomarker reflecting the activity of the histaminergic nervous system, and is associated with the development and progression of neurological disorders such as Alzheimer's disease and narcolepsy[2]. 1-Methylhistamine also has the potential to be a biomarker for inflammatory diseases, as changes in its levels are associated with conditions such as allergic reactions and mast cell activation syndrome[3].
References:
[1] Shan L, Fronczek R, Lammers GJ, et al. The tuberomamillary nucleus in neuropsychiatric disorders. Handb Clin Neurol. 2021;180:389-400.
[2] Gabelle A, Jaussent I, Hirtz C, et al. Cerebrospinal fluid levels of orexin-A and histamine, and sleep profile within the Alzheimer process. Neurobiol Aging. 2017 May;53:59-66.
[3] Hsu WH, Wang SY, Chao YM, et al. Novel metabolic and lipidomic biomarkers of sarcopenia. J Cachexia Sarcopenia Muscle. 2024 Oct;15(5):2175-2186.
1-Methylhistamine是一种由组胺经组胺-N-甲基转移酶（HNMT）催化产生的主要代谢产物，用于评估体内组胺的代谢水平[1]。1-Methylhistamine作为组胺在中枢神经系统和外周组织中的主要灭活产物，其浓度（尤其在脑脊液和尿液中）可作为反映组胺能神经系统活性的生物标志物，与阿尔茨海默病、嗜睡症等神经系统疾病发生发展相关 [2]。1-Methylhistamine还具有作为炎症性疾病生物标志物的潜力，其水平变化与过敏反应及肥大细胞活化综合征等疾病相关[3]。