Guanosine is a purine nucleoside that is comprised of the purine base guanine attached to a ribose moiety.1 Mono-, di-, tri-, and cyclic monophosphorylated forms of guanosine (GMP, GDP, GTP, and cGMP, respectively) are essential for a variety of endogenous biochemical processes, such as signal transduction, metabolism, and RNA synthesis.2,3,4
1.Voet, D., and Voet, J.G.Biochemistry1591(2004) 2.Hanson, R.W., and Garber, A.J.Phosphoenolpyruvate carboxykinase. I. Its role in gluconeogenesisAm. J. Clin. Nutr.25(10)1010-1021(1972) 3.Neer, E.J.G proteins: Critical control points for transmembrane signalsProtein Sci.3(1)3-14(1994) 4.Ohta, T., Sarkar, S., and Thach, R.E.The role of guanosine 5'-triphosphate in the initiation of peptide synthesis. III. Binding of formylmethionyl-tRNA to ribosomesProc. Natl. Acad. Sci. USA58(4)1638-1644(1967)