GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC31080 structure
    GC31080GOAT-IN-1
    CAS: 1452473-54-9

    GOAT-IN-1是胃促生长素O-酰基转移酶(GOAT)的抑制剂，可用于预防或治疗肥胖、糖尿病、高脂血症、非酒精性脂肪肝、脂肪性肝炎、骨骼肌减少症、食欲控制、酒精/麻醉性依赖、阿尔茨海默症、帕金森、脑血管疾病与老年痴呆、脑卒中、脑梗死、心血管疾病、一些肿瘤等。

  • GC31103 structure
    GC31103Arimoclomol maleate (BRX-220)
    CAS: 289893-26-1
    纯度: >99.50%

    A co-inducer of heat shock proteins

  • GC31118 structure
    GC31118KU-32
    CAS: 956498-70-7

    KU-32是一种新型的，基于新生霉素的Hsp90抑制剂，可以预防神经细胞死亡。

  • GC31123 structure
    GC31123Mitochonic acid 5 (MA-5)
    CAS: 1354707-41-7
    纯度: >99.00%

    An inhibitor of mitochondrial dysfunction

  • GC31180 structure
    GC31180Royal Jelly acid (Queen Bee Acid)
    CAS: 14113-05-4
    纯度: >98.00%

    An unsaturated fatty acid found in royal jelly

  • GC31186 structure
    GC31186Citicoline sodium salt
    CAS: 33818-15-4
    纯度: >99.50%

    Citicoline sodium salt是胞磷胆碱的水溶性形式，胞磷胆碱是磷脂酰胆碱合成过程中的天然中间体，作为乙酰胆碱和磷脂酰胆碱在大脑中的前体，具有抑制活性氧（ROS）产生和细胞凋亡的生物学功能。

  • GC31210 structure
    GC31210Paraxanthine
    CAS: 611-59-6
    纯度: >98.00%

    An active metabolite of caffeine

  • GC31219 structure
    GC312198-Hydroxyguanosine
    CAS: 3868-31-3
    纯度: >99.50%

    An oxidized nucleoside and a marker of RNA oxidative damage

  • GC31222 structure
    GC312222-Hydroxy-3-methylbutanoic acid
    CAS: 4026-18-0

    2-Hydroxy-3-methylbutanoic acid (3-Methyl-2-hydroxybutyric acid, 2-Hydroxyisopentanoic acid, 2-Oxyisovaleric acid) is a metabolite found in the urine of patients with phenylketonuria, methylmalonic acidemia, propionic acidemia, 3-ketothiolase deficiency, isovaleric acidemia, 3-methylcrotonylglycemia, 3-hydroxy-3-methylglutaric acidemia, multiple carboxylase deficiency, glutaric aciduria, ornithine transcarbamylase deficiency, glyceroluria, tyrosinemia type I, galactosemia, and maple syrup urine disease.

  • GC31223 structure
    GC31223Tyramine
    CAS: 51-67-2
    纯度: >99.50%

    A monoamine and TAAR1 agonist

  • GC31235 structure
    GC31235Cirsiliol
    CAS: 34334-69-5

    A flavonoid with diverse biological activities

  • GC31240 structure
    GC31240Stearoylethanolamide
    CAS: 111-57-9
    纯度: >98.00% / >95.00%

    An endocannabinoid

  • GC31241 structure
    GC31241D-Arabitol
    CAS: 488-82-4
    纯度: >95.00%

    A fungal metabolite

  • GC31242 structure
    GC31242LNK754
    CAS: 439153-64-7

    LNK754 是 CP-609754 的外消旋体。

  • GC31253 structure
    GC31253Palmitoleic acid
    CAS: 373-49-9
    纯度: >99.00% / >98.00% / >99.50%

    Palmitoleic acid是一种omega-7单不饱和脂肪酸，在澳洲坚果植物中含量很高。

  • GC31267 structure
    GC31267NEP-In-1
    CAS: 465527-94-0

    NEP-IN-1是一种中性肽链内切酶(NEP)抑制剂，抑制dNEP,IC50为2nM。

  • GC31276 structure
    GC31276Prenyl-IN-1
    CAS: 360561-53-1

    Prenyl-IN-1是一种prenylation抑制剂，尤其是香叶烯基转移酶(geranylgeranyltransferase)或法尼基转移酶(farnesyltransferase)的抑制剂，在帕金森研究中，具有抗氧化应激作用。

  • GC31282 structure
    GC31282p-Hydroxybenzaldehyde
    CAS: 123-08-0

    p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons. p-Hydroxybenzaldehyde at 101.7 μM can significantly reduce the GABA-induced chloride current of GABAA receptors(α1β2γ2S subtype) expressed.

  • GC31290 structure
    GC312903-Indolepropionic acid
    CAS: 830-96-6
    纯度: >99.50%

    A bacterial metabolite with antioxidant and neuroprotective activities

  • GC31307 structure
    GC313074-Methyl-2-oxopentanoic acid
    CAS: 816-66-0
    纯度: >99.00% / >98.00%

    4-Methyl-2-oxopentanoic acid是一种异常代谢物、神经毒素和代谢毒素。4-Methyl-2-oxopentanoic acid通过损害 mTOR 和自噬信号通路，增加内质网应激，促进前脂肪细胞脂质积累和胰岛素抵抗。

  • GC31316 structure
    GC31316H-Phe-Phe-OH
    CAS: 2577-40-4
    纯度: >98.00% / >99.50%

    H-Phe-Phe-OH (Phenylalanyl-phenylalanine, Phe-Phe, L-Phe-L-Phe) is a short peptide diphenylalanine with utility for potential applications in biomaterial chemistry, sensors and bioelectronics.

  • GC31317 structure
    GC31317Sitagliptin (MK0431)
    CAS: 486460-32-6
    纯度: >99.50%

    Sitagliptin (MK0431) 是一种口服、高选择性的二肽基肽酶-4（DPP-4）抑制剂，IC 50 为18nM。

  • GC31328 structure
    GC31328Thyroxine sulfate (T4 Sulfate)
    CAS: 77074-49-8
    纯度: >99.50%

    硫酸甲状腺素 (T4 Sulfate) 是一种甲状腺激素代谢物。

  • GC31333 structure
    GC31333Teneligliptin (MP-513)
    CAS: 760937-92-6
    纯度: >99.50%

    Teneliligliptin (MP-513) (MP-513) 是一种有效的、可口服的、有竞争力的、长效的 DPP-4 抑制剂。