Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC38690 D-Glucuronic acid lactone
葡醛内酯; 葡糖醛酸內酯; D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone
D-Glucurone is a glucuronic acid derivative that is used for treating canine hepatitis.
GC38689 Poly(4-vinylphenol)
聚（4-乙基苯酚）
Poly(4-vinylphenol) 是一种内源性代谢产物。
GC38688 Inosine 5'-monophosphate disodium salt (hydrate)
肌苷5-单磷酸二钠盐水合物,5'-IMP (disodium)(hydrate
Disodium 5'-inosinate monohydrate (Inosine 5'-monophosphate disodium salt hydrate) is an endogenous metabolite.
GC38684 (E)-m-Coumaric acid
3-羟基肉桂酸
3-hydroxycinnamic acid (meta-Coumaric acid, m-Coumaric acid, m-Coumarate) is an aromatic acid that can be found in vinegar.
GC38670 1-Hydroxyoctadecane
硬脂醇
1-Hydroxyoctadecane 是一种内源性代谢产物。
GC38669 3-Hydroxybenzoic acid 3-Hydroxybenzoic acid 是一种内源性代谢产物。
GC38660 Megestrol
甲地孕酮
Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.
GC38654 Bis(2-ethylhexyl) phthalate
邻苯二甲酸二(2-乙基己)酯,Bis(2-ethylhexyl) phthalate; Ergoplast FDO; ESBO-D 82
Bis(2-ethylhexyl) phthalate，通常称为DEHP，是一种合成化合物，主要用作增塑剂。接触Bis(2-ethylhexyl) phthalate会对生物体产生各种不良影响，如生殖和发育受损、癌症、代谢改变以及神经和行为障碍。
GC38644 Glycodeoxycholic Acid
甘氨脱氧胆酸；甘氨去氧胆酸
Glycodeoxycholic Acid是脱氧胆酸的甘氨酸结合形式。
GC38640 IDH889 IDH889 是一种可口服利用的，脑渗透性的，变构和突变特异性的异柠檬酸脱氢酶 (IDH1) 抑制剂。IDH889 对 IDH1 R132* 突变型具有高效选择性，对 IDH1R132H、IDH1R132C 和 IDH1wt 作用的 IC50 值分别为 0.02 μM, 0.072 μM 和 1.38 μM。IDH889 具有高效的细胞内 2-HG 水平抑制作用，其 IC50 值为 0.014 μM。
GC38638 Euphol
大戟二烯醇
真酚(Euphol)是Euphorbia tirucalli中的主要成分,真酚可逆的抑制丝氨酸水解酶MGL活性(IC50 = 315 nM)。
GC38636 Glabrol
光甘草醇
Glabrol (Compound 1) 是从甘草根的乙醇提取物中分离得到的一种异戊二烯类黄酮，是一种有效且非竞争性的 ACAT (酰基辅酶 A:胆固醇酰基转移酶)抑制剂，对大鼠肝脏微粒体 ACAT 的 IC50 值为 24.6 μM。
GC38620 Dihydrorotenone
二氢鱼藤酮
Dihydrorotenone是一种杀虫剂，是线粒体复合物I的不可逆抑制剂，并且能够穿过血脑屏障。
GC38604 Glomeratose A
球腺糖A
Glomeratose A 是一种乳酸脱氢酶 lactate dehydrogenase 抑制剂，是从远志 Polygala tenuifolia 分离的。
GC38593 Ethyl glucuronide
乙基Β-D-葡萄糖醛酸
Ethyl glucuronide是乙醇的一种非挥发性、水溶性的直接代谢物，可在体液、组织和毛发中检测到。
GC38587 H-Arg-Lys-OH TFA H-Arg-Lys-OH TFA 是由 L-精氨酸和 L-赖氨酸残基形成的二肽。
GC38574 Cholesteryl arachidonate
Arachidonic Acid cholesteryl ester, Cholesterol Arachidonate, Cholesterol 5Z,8Z,11Z,14-Z-Eicosatetraenoic Acid ester, 20:4 Cholesteryl ester
A cholesterol ester
GC38560 Oleoylcarnitine
CAR 18:1, C18:1 Carnitine, L-Carnitine oleoyl ester, L-Oleoylcarnitine
A long-chain acylcarnitine
GC38556 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine 是一种内源性代谢产物。
GC38552 Tetrahydrocortisol
氧戊环
An endogenous metabolite of cortisol
GC38503 HSP27 inhibitor J2
J2
HSP27抑制剂J2 (J2)是HSP27的抑制剂,能显著诱导异常HSP27二聚体形成,抑制HSP27大聚合物的生成。
GC38488 Hinokiflavone
扁柏双黄酮
Hinokiflavone, isolated from Selaginella P. Beauv, Juniperus phoenicea and Rhus succedanea, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway.
GC38463 ASLAN003
ASLAN003
A DHODH inhibitor
GC38457 Lapaquistat
T-91485
Lapaquistat (T-91485) 是一种胆固醇生物合成 cholesterol biosynthesis 的抑制剂，是 TAK-475 的活性代谢产物。Lapaquistat 可以降低他汀类药物在降脂治疗中的肌毒性。
GC38452 Dehydrotrametenolic acid
去氢齿孔酸
Dehydrotrametenolic acid 是从茯苓 (Poria cocos) 的菌核中分离的甾醇。Dehydrotrametenolic acid 通过 caspase-3 途径诱导细胞凋亡。Dehydrotrametenolic acid 具有抗肿瘤活性，抗炎，抗糖尿病作用。
GC38440 Guaiazulene
愈疮奥
A sesquiterpene with diverse biological activities
GC38438 Synephrine
辛弗林; Oxedrine
Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
GC38382 CNDAC hydrochloride CNDAC hydrochloride 是可口服试剂 sapacitabine 的代谢物，为核苷酸类似物。
GC38371 (S)-(-)-Phenylethanol
S-(-)-苯乙醇
(S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties.
GC38370 N-Acetyl-L-leucine
N-乙酰-L-亮氨酸
N-acetyl-L-leucine is an active endogenous metabolite that accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus.
GC38369 (±)-Leucine
DL-亮氨酸,DL-Leucine; (RS)-Leucine
(±)-Leucine 是一种内源性代谢产物。
GC38368 3-Furanoic acid
3-糠酸
3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals.
GC38367 2,4-Dihydroxypyrimidine-5-carboxylic Acid
脲嘧啶-5-羧酸
2,4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid, Isoorotic acid, 5-Carboxyuracil) is an endogenous metabolite.
GC38366 Pyridoxylamine dihydrochloride
盐酸吡多胺; Pyridoxamine dihydrochloride

A 4-methylamine form of vitamin B₆
GC38364 (R)-Ornithine hydrochloride
D-鸟氨酸盐酸盐,(R)-Ornithine hydrochloride

An enantiomer of L-ornithine
GC38363 (R)-pyrrolidine-2-carboxylic acid
D-脯氨酸,(+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline
D-proline is an isomer of the naturally occurring amino acid, L-Proline.
GC38362 KSD 2405
3-羟基苯甲醇
3-Hydroxybenzyl alcohol is used as an intermediate to produce other chemicals.
GC38360 3-Methylbut-2-enoic acid
3,3-二甲基丙烯酸
Senecioic acid (3-Methylcrotonic acid, 3,3-Dimethylacrylic acid, β-Methylcrotonic Acid) is an unsaturated fatty acid found in the pheromones of mealybug species and appears in the urine of patients with 3-Methylcrotonic aciduria.
GC38359 1H-pyrazole
吡唑
Pyrazole (1H-pyrazole) is a five membered heteroaromatic ring with two nitrogen atoms is of immense significance. Pyrazole is an indispensable anchor for design and development of new pharmacological agents.
GC38358 5'-Cytidylic acid
胞苷酸; 5'-Cytidylic acid; 5'-CMP
A pyrimidine nucleotide
GC38356 Imidazoleacetic acid hydrochloride
4-咪唑乙酸盐酸盐,Imidazolyl-4-acetic acid hydrochloride
Imidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors.
GC38332 Ximelagatran
希美加群,H 376/95
A prodrug of melagatran, a thrombin inhibitor
GC38327 Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrate
异柠檬酸三钠盐
Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrate是三羧酸循环（TCA Cycle）中的关键中间产物，能够作为反应底物测定Isocitrate Dehydrogenase的活性
GC38326 NSC 13138
喹啉-4-羧酸,Cinchoninic acid (6CI,7CI,8CI); 4-Carboxyquinoline
Quinoline-4-carboxylic acid (4-Carboxyquinoline) is a very important structure in a synthetic medicinal chemistry.
GC38325 N-Acetyl-D-mannosamine monohydrate
N-乙酰-D-甘露糖胺,Cyclic ManNAc
A precusor of sialic acid
GC38324 D-Galacturonic acid (hydrate)
D-半乳糖醛酸

A monosaccharide
GC38323 Tetrahydro-2H-pyran-2-one
delta-戊内酯
δ-Valerolactone (Tetrahydro-2H-pyran-2-one, 5-Valerolactone, oxan-2-one) is an endogenous metabolite.
GC38321 2-Aminopyrimidin-5-ol
2-氨基-5-羟基嘧啶
2-Aminopyrimidin-5-ol 是一种内源性代谢产物。
GC38320 L-Methionine sulfoxide
L-蛋氨酸亚砜,H-Met(O)-OH
L-Methionine sulfoxide (H-Met(O)-OH)，甲硫氨酸的代谢产物，诱导 M1/classical 巨噬细胞极化，并调节氧化应激和嘌呤能的信号传递参数。
GC38317 Acetamide
乙酰胺
Acetamide (ethanamide, Acetic acid amide) is an organic compound that can be used as a plasticizer and an industrial solvent.