Royal Jelly acid (Queen Bee Acid)

10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees.¹ 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 μM.² It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 μM.^3,4 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 μM and 1.5 mM, respectively.^5,6

1.Kodai, T., Umebayashi, K., Nakatani, T., et al.Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera)Chem. Pharm. Bull. (Tokyo)55(10)1528-1531(2007) 2.Honda, Y., Fujita, Y., Maruyama, H., et al.Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegansPLoS One6(8)1-10(2011) 3.Wang, J.g., Ruan, J., Li, C.Y., et al.Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritisRheumatol. Int.(2011) 4.Izuta, H., Chikaraishi, Y., Shimazawa, M., et al.10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cellsEvid. Based Complement. Alternat. Med.6(4)489-494(2009) 5.Hattori, N., Nomoto, H., Fukumitsu, H., et al.Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitroBiomed. Res.28(5)261-266(2007) 6.Koya-Miyata, S., Okamoto, I., Ushio, S., et al.Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanismBiosci. Biotechnol. Biochem.68(4)767-773(2004)