Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC38301 2-(1H-Indol-3-yl)ethan-1-ol
色醇; Tryptophol; Indole-3-ethanol
An indole with diverse biological activities
GC38300 Phytic acid potassium
植酸二钾
Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.
GC38299 (2-Aminoethyl)phosphonic acid
2-氨基乙基膦酸
2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages.
GC38298 Pteridine-2,4(1H,3H)-dione
2,4-二羟基蝶啶
Pteridine-2,4(1H,3H)-dione 是一种内源性代谢产物。
GC38297 3-Methylindolin-2-one
3-甲基羟基吲哚
3-Methylindolin-2-one 是一种内源性代谢产物。
GC38296 (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride
盐酸D-甘露糖胺
An amino monosaccharide
GC38295 N-Acetyl-DL-methionine
N-乙酰-DL-甲硫氨酸
N-Acetyl-DL-methionine is an active endogenous metabolite that decreases the hepatic glutathione level in male Bom:NMRI mice.
GC38294 Heptadecanoic acid
十七烷酸
An odd-chain saturated fatty acid
GC38293 3-Amino-4-hydroxybenzoic acid
3-氨基-4-羟基苯甲酸
3-Amino-4-hydroxybenzoic acid is a monohydroxybenzoic acid.
GC38292 H-Trp-NH2.HCl
L-色氨酰胺盐酸盐
An endogenous metabolite of L-tryptophan
GC38291 Indole
吲哚
Indole (2,3-Benzopyrrole) is an aromatic heterocyclic organic compound widely distributed in the natural environment and can be produced by a variety of bacteria.
GC38290 NSC 45699
N-乙酰-L-苯丙氨酸; N-Acetylphenylalanine
A metabolite of L-phenylalanine
GC38289 N-Methylmethanamine hydrochloride
二甲胺盐酸盐
N-Methylmethanamine hydrochloride 是一种内源性代谢产物。
GC38288 Maleimide
马来酰亚胺
Maleimide exhibits fluorescence quenching ability and can be used for the specific detection of thiol analytes as fluorogenic probes. Maleimide is also used for production of antibody-drug conjugate (ADC) which is used in cancer research.
GC38287 α-Pyridone
2-羟基吡啶,Pyridin-2-one; α-Hydroxypyridine
2-Hydroxypyridine (2-Pyridino, 2-Pyridone) is used in peptide synthesis.
GC38286 5,6-Dimethyl-1H-benzo[d]imidazole
5,6-二甲基苯并咪唑
5,6-Dimethylbenzimidazole (5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole) is a vitamin B12 precursor.
GC38285 Flavonol
3-羟基黄酮
A synthetic flavonol
GC38284 Glycerophosphoric acid disodium salt hydrate
β-甘油磷酸钠水合物

Glycerophosphoric acid disodium salt hydrate 是一种内源性代谢物，是一种磷酸酶抑制剂。
GC38283 (3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one
D-塔格糖; D-(-)-Tagatose
D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy.
GC38282 (R)-5-Oxopyrrolidine-2-carboxylic acid
D-焦谷氨酸
A metabolite of D-glutamate
GC38281 2-Hydroxy-2-phenylacetic acid
扁桃酸,(±)-Mandelic acid; DL-Mandelic acid
2-羟基-2-苯乙酸（(±)-2-羟基-2-苯乙酸）是一种α-羟基羧酸，已广泛用作医药和精细化学品的中间体。
GC38277 trans-Cyclohexane-1,2-diol
1,2-环己二醇，顺反混合物
trans-Cyclohexane-1,2-diol 是一种内源性代谢产物。
GC38276 2-Oxosuccinic acid
草酰乙酸; 2-Oxosuccinic acid
2-Oxosuccinic acid（草酰乙酸）是一种α-酮酸，在柠檬酸循环的第一步中草酰乙酸与乙酰辅酶A和水反应形成柠檬酸盐，并在最后一步中通过L-苹果酸的氧化再生。
GC38275 Purine
嘌呤; Purine (6CI,8CI); 3,5,7-Triazaindole; 3H-Imidazo[4,5-d]pyrimidine; 6H-Imidazo[4,5-d]pyrimidine; 7H-Purine; Isopurine; NSC 753; β-Purine
An aromatic heterocyclic organic compound
GC38274 Oxalic acid dihydrate
草酸二水合物
Oxalic acid dihydrate 是一种内源性代谢产物。
GC38273 Methyl 2-(1H-indol-3-yl)acetate
吲哚-3-醋酸甲酯
Methyl 3-indolyacetate is a phytohormone.
GC38272 H-Phg(4-OH)-OH
L-(+)-对羟基苯甘氨酸,L-p-Hydroxyphenylglycine; 4-Hydroxy-L-phenylglycine; UK 25842
A CPT1 inhibitor and prodrug form of 4-hydroxyphenylglyoxylic acid
GC38271 1-Hydroxy-2-naphthoic acid
1-羟基-2-萘甲酸
1-Hydroxy-2-naphthoic acid is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms.
GC38270 1-Aminocyclopropane-1-carboxylic acid
1-氨基环丙烷羧酸
An NMDA receptor partial agonist
GC38268 Indole-3-acetamide
3-吲哚乙酰胺
Indole-3-acetamide是吲哚-3-乙酸的生物合成中间体。
GC38266 Quinoline-2-carboxylic acid
喹哪啶酸
Quinaldic acid is a product of l-tryptophan catabolism, via kynurenic acid, found in human urine.
GC38265 (2R,3R)-2,3-Dihydroxysuccinic acid
L-酒石酸; L-(+)-Tartaric acid
Tartaric acid (2,3-Dihydroxysuccinic acid, Threaric acid, Racemic acid, Uvic acid, Paratartaric acid, Winestone) is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes. It has several applications for industrial and pharmaceutical use.
GC38264 Ac-Ala-OH
N-乙酰-L-丙氨酸
N-Acetyl-L-alanine (NAAL, Ac-Ala-OH) is an active endogenous metabolite.
GC38262 (R)-(-)-1,3-Butanediol
(R)-(-)-1,3-丁二醇
(R)-(-)-1,3-Butanediol 可以用于调节糖类脂类代谢。
GC38261 H-allo-Thr-OH
L-别苏氨酸,H-allo-Thr-OH
H-allo-Thr-OH 是一种内源性代谢产物。
GC38260 2-Aminobenzenesulfonic acid
2-氨基苯磺酸
2-Aminobenzenesulfonic acid (Orthanilic acid, O-Aminobenzenesulfonic acid, Aniline-2-sulfonic acid) is a biological acid with roles in benzoate degradation and microbial metabolism in diverse environments.
GC38259 H-D-cis-Hyp-OH
顺式-4-羟基-D-脯氨酸；顺-4-羟基-D-脯氨酸
cis-4-Hydroxy-D-proline (H-D-cis-Hyp-OH) is an endogenous metabolite that can be used to study the specificity and kinetics of D-alanine dehydrogenase.
GC38258 2'-Deoxyadenosine-5'-monophosphate
2'-脱氧腺苷-5'-单磷酸
A deoxynucleotide
GC38257 3-Ethoxy-3-oxopropanoic acid
3-乙氧基-3-氧代丙酸
Monoethyl malonic acid (Ethyl hydrogen malonate, Monoethyl malonate, 3-Ethoxy-3-oxopropanoic acid) is the major urinary metabolites of ethyl 3-ethoxypropionate (EEP).
GC38249 D-Glucuronic acid
D-葡萄糖醛酸
A metabolite of glucose
GC38248 Oxalic Acid
草酸; Ethanedioic acid
Oxalic acid (Ethanedioic acid, Wood bleach) is a strong dicarboxylic acid occurring in many plants and vegetables.
GC38246 Undecanoic acid
十一烷酸,Undecanoate; Hendecanoic acid
An eleven carbon SFA
GC38243 2,3-Diaminopropanoic acid hydrochloride
DL-2,3-二胺基丙酸盐酸盐
DL-2,3-Diaminopropionic acid monohydrochloride (2,3-Diaminopropanoic acid hydrochloride) is an active endogenous metabolite.
GC38242 1,4-Dioxane-2,5-diol
乙醇醛二聚体(羟基乙醛二聚体)
Glycolaldehyde dimer (2,5-Dihydroxy-1,4-dioxane, 1,4-Dioxane-2,5-diol, DD) is an active endogenous metabolite that appears moderate absorbent and fluorescent, when it reacts with glycine (Gly)/ammonium sulfate (AS).
GC38235 Cuminaldehyde
4-异丙基苯甲醛
4-Isopropylbenzaldehyde (Cuminaldehyde, Cuminic aldehyde, Cuminal), a natural organic compound, is a kind of pharmaceutical intermediate with a pleasant smell and contributes to the aroma of essential oils.
GC38223 Dihydroberberine
二氢小檗碱
Dihydroberberine是一种强效的haematopoietic prostaglandin D2 synthase (H-PGDS)抑制剂，IC₅₀值为3.7µM。
GC38205 cis-9,10-Epoxystearic acid
cis-9,10-Epoxyoctadecanoic acid
An epoxy fatty acid
GC38191 2'-Deoxyguanosine monohydrate
2'-脱氧鸟苷一水合物
A purine nucleoside with diverse biological activities
GC38190 2-Hydroxyhexanoic acid
Α-羥己酸
2-Hydroxyhexanoic acid (2-Hydroxyhexanoic acid) is an endogenous metabolite.
GC38178 D-Methionine sulfoxide
D-甲硫氨酸亚砜
D-methionine sulfoxide 是 Methionine sulfoxide 的 D 型异构体。Methionine sulfoxide 是 Methionine 的氧化产物。Methionine 是牛奶或豆类蛋白中的限制性氨基酸，在储存或加工过程中易被氧化。