GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC31337 structure
    GC31337Spermidine (N-(4-Aminobutyl)-1,3-diaminopropane)
    CAS: 124-20-9
    纯度: >99.00%

    Spermidine是一种天然多胺，可通过与DNA/RNA结合并稳定其结构、发挥抗氧化活性、调节酶功能以及参与翻译调控来维持细胞稳态。

  • GC31341 structure
    GC31341Anagliptin (SK-0403)
    CAS: 739366-20-2

    A DPP-4 inhibitor

  • GC31344 structure
    GC31344MK-4074
    CAS: 1039758-22-9
    纯度: >99.50%

    MK-4074是乙酰辅酶A羧化酶(acetyl-CoAcarboxylase)的肝特异性抑制剂，IC50值约为3nM。

  • GC31352 structure
    GC31352Sucrose (D-(+)-Saccharose)
    CAS: 57-50-1
    纯度: >98.00%

    Sucrose (D-(+)-Saccharose), a common sugar produced naturally in plants, is a disaccharide, a molecule composed of two monosaccharides:glucose and fructose.

  • GC31353 structure
    GC31353Glutathione oxidized (L-Glutathione oxidized)
    CAS: 27025-41-8
    纯度: >98.50% / >99.00%

    Glutathione oxidized (L-Glutathione oxidized)，是抗氧化剂L-谷胱甘肽的氧化形式，作为一种信号分子，可触发抗氧化基因的激活。

  • GC31354 structure
    GC31354MLN-4760
    CAS: 305335-31-3
    纯度: >99.00%

    MLN-4760是一种选择性的人血管紧张素转换酶2（ACE2；IC 50 =0.44nM）抑制剂，MLN-4760可高亲和力地结合ACE2的活性位点锌离子，模拟肽水解过程中的过渡态，从而阻断血管紧张素II向血管紧张素(1-7)的转化。

  • GC31356 structure
    GC31356HTS01037
    CAS: 682741-29-3
    纯度: >99.50%

    An antagonist of A- FABP/aP2 protein- protein interactions

  • GC31362 structure
    GC31362MGAT2-IN-1
    CAS: 1800025-30-2
    纯度: >99.00%

    MGAT2-IN-1是一种可口服的单酰甘油酰基转移酶(MGAT2)抑制剂，对人和小鼠MGAT2的IC50值分别为7.8和2.4nM。

  • GC31375 structure
    GC31375PF-06471553
    CAS: 1808094-07-6
    纯度: >98.00%

    PF-06471553是一种有效的，选择性的，可口服的monoacylglycerolacyltransferase3(MGAT3)抑制剂，IC50值为92nM。

  • GC31384 structure
    GC31384FCE 28654
    CAS: 169474-77-5

    FCE28654是一种水溶的酰基COA:胆固醇酰基转移酶(ACAT)抑制剂，在兔主动脉、肠和猴肝脏的微粒体中，抑制ACAT的活性，IC50值分别为2.55，1.08和5.69μM。

  • GC31390 structure
    GC31390EP1013 (F1013)
    CAS: 223568-55-6

    EP1013 (F1013) (F1013) 是一种广谱 caspase 选择性抑制剂，用于 1 型糖尿病的研究。

  • GC31397 structure
    GC31397Guanidine hydrochloride (Guanidinium chloride)
    CAS: 50-01-1

    Guanidine盐酸盐是蛋白代谢产物和蛋白变性剂，由鸟嘌呤氧化形成。

  • GC31398 structure
    GC31398Stearic acid
    CAS: 57-11-4
    纯度: >98.00%

    A long-chain saturated fatty acid

  • GC31401 structure
    GC31401Cholesteryl behenate (Cholesteryl docosanoate)
    CAS: 61510-09-6
    纯度: >98.00%

    A cholesterol ester

  • GC31403 structure
    GC31403H-HoPro-OH
    CAS: 3105-95-1
    纯度: >98.00%

    L(-)-Pipecolinic acid (L-Homoproline) is a normal human metabolite present in human blood.

  • GC31414 structure
    GC31414Diprotin A TFA (Ile-Pro-Pro (TFA))
    CAS: 209248-71-5
    纯度: >98.50%

    A tripeptide inhibitor of DPP-4

  • GC31419 structure
    GC31419L-Gulono-1,4-lactone
    CAS: 1128-23-0

    L-Gulono-1,4-lactone (L-Gulonolactone, L-Gulono-gamma-lactone, reduced ascorbic acid) is the substrate of the enzyme L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic acid (vitamin C) in plants and animals.

  • GC31420 structure
    GC31420all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid)
    CAS: 38030-57-8

    An active metabolite of all- trans retinoic acid

  • GC31423 structure
    GC31423Dodecanoylcarnitine
    CAS: 25518-54-1
    纯度: >98.00%

    Dodecanoylcarnitine和脂肪酸氧化紊乱有关，如长链酰基辅酶脱氢酶缺乏症、肉毒棕榈酰基转移酶I/II缺乏症，也和乳糜泻有关。

  • GC31428 structure
    GC31428H-Gly-Pro-OH
    CAS: 704-15-4

    H-Gly-Pro-OH (Glycyl proline, Glycyl-L-proline) is a dipeptide composed of glycine and proline, and is an end product of collagen metabolism that is further cleaved by prolidase. The resulting proline molecules are recycled into collagen or other proteins.

  • GC31432 structure
    GC31432Asp-AMS
    CAS: 828288-98-8

    Asp-AMS是天冬氨酸腺苷酸的一个类似物，是aspartyl-tRNA合成酶(aspartyl-tRNAsynthetase)的一个抑制剂，也是线粒体酶(mitochondrialenzyme)的强效竞争性抑制剂。

  • GC31435 structure
    GC314352-Methylsuccinic acid
    CAS: 498-21-5
    纯度: >95.00%

    2-Methylsuccinic acid (Pyrotartaric acid, 2-methylbutanedioic acid, propane-1,2-dicarboxylic acid, Methylsuccinate) is a normal metabolite found in human fluids.

  • GC31438 structure
    GC31438Maltotetraose (Amylotetraose)
    CAS: 34612-38-9
    纯度: >98.00%

    A tetrasaccharide

  • GC31443 structure
    GC31443YM17E
    CAS: 124900-72-7

    YM17E是一种酰基辅酶a:胆固醇酰基转移酶(ACAT)的抑制剂，在兔肝微粒体的体外实验中，IC50值为44nM。