GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC31444 structure
    GC31444Saikogenin A
    CAS: 5092-09-1
    纯度: >98.00%

    SaikogeninA可从中药柴胡中提取，是一种二肽基肽酶IV(DPP-IV)抑制剂。

  • GC31463 structure
    GC31463Gosogliptin (PF-00734200)
    CAS: 869490-23-3
    纯度: >98.50%

    An inhibitor of DPP-4

  • GC31465 structure
    GC31465L-873724
    CAS: 603139-12-4

    L-873724是一种有效、可口服、选择性、可逆的非碱性cathepsinK抑制剂，对cathepsinK，cathepsinS，cathepsinL，cathepsinB的IC50值分别为0.2，178，264和5239nM。L-873724抑制兔子cathepsinK的活性，IC50值为0.5nM，同时可抑制骨再吸收

  • GC31467 structure
    GC31467Dutogliptin
    CAS: 852329-66-9
    纯度: >99.00%

    Dutogliptin是一种口服有效的选择性二肽基肽酶-4(DPP4)抑制剂。

  • GC31472 structure
    GC31472Retagliptin Phosphate (SP 2086)
    CAS: 1256756-88-3
    纯度: >99.50%

    Retagliptin Phosphate (SP 2086) (SP2086 phosphate) 是一种选择性、竞争性和口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。

  • GC31491 structure
    GC31491Speract
    CAS: 76901-59-2

    Speract是一种调节精子活力的海胆蛋肽，也刺激精子线粒体代谢。

  • GC31492 structure
    GC31492Vildagliptin dihydrate (LAF237 dihydrate)
    CAS: 2133364-01-7

    A DPP-4 inhibitor

  • GC31493 structure
    GC31493Galactose 1-phosphate Potassium salt
    CAS: 19046-60-7
    纯度: >98.00%

    An intermediate in the interconversion of glucose and galactose

  • GC31494 structure
    GC31494Lodelaben (SC-39026)
    CAS: 111149-90-7

    Lodelaben (SC-39026) 是一种人中性粒细胞弹性蛋白酶抑制剂，IC50 和 Ki 分别为 0.5 和 1.5 μM。

  • GC31511 structure
    GC31511Sinapinic acid (Sinapic acid)
    CAS: 530-59-6
    纯度: >99.50%

    A phenylpropanoid hydroxycinnamic acid with diverse biological activities

  • GC31516 structure
    GC31516YM-53601 free base
    CAS: 182959-28-0

    A squalene synthase inhibitor

  • GC31524 structure
    GC31524Glycylglycine
    CAS: 556-50-3

    Glycylglycine (Diglycine, Diglycocoll, Glycine dipeptide), the simplest peptide made of two glycine molecules, is usually used in the synthesis of more complicated peptides.

  • GC31535 structure
    GC315353-Methyl-L-histidine
    CAS: 368-16-1
    纯度: >98.00% / >99.50%

    An amino acid

  • GC31536 structure
    GC31536N-Oleoyl glycine
    CAS: 2601-90-3
    纯度: >98.00%

    A putative substrate for peptidyl glycine α- amidating enzyme

  • GC31539 structure
    GC31539D-Gluconic acid solution
    CAS: 526-95-4
    纯度: >50.00%

    D-Gluconic acid is an antifungal agent.

  • GC31540 structure
    GC31540Methionine sulfoxide
    CAS: 62697-73-8
    纯度: >98.00%

    Methioninesulfoxide是一种具有活性氧的甲硫氨酸的氧化产物，可被当做体内氧化应激的生物标记。

  • GC31544 structure
    GC315442-Hydroxy-2-methylbutanoic acid
    CAS: 3739-30-8

    2-Hydroxy-2-methylbutyric acid is an unusual metabolite found in the urine of patients with 2-hydroxyglutaric aciduria and maple syrup urine disease. 2-Hydroxy-2-methylbutyric acid is also a secondary metabolite found in human urine after exposure to the gasoline additive tert-amyl-Me-ether (TAME).

  • GC31546 structure
    GC315463-Methyladipic acid
    CAS: 3058-01-3
    纯度: >99.00%

    A catabolite of phytanic acid

  • GC31547 structure
    GC31547DPP-IV-IN-1
    CAS: 625110-37-4

    DPP-IV-IN-1是一种有效的dipeptidylpeptidaseIV(DPP-IV)抑制剂，IC50值为4.6nM；DPP-IV为一种特异性的丝氨酸蛋白酶(serineprotease)。

  • GC31548 structure
    GC31548ACAT-IN-1 cis isomer
    CAS: 145961-79-1

    ACAT-IN-1cisisomer是有效地ACAT抑制剂，IC50值为100nM。

  • GC31549 structure
    GC31549Glycolic acid
    CAS: 79-14-1

    Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

  • GC31550 structure
    GC31550E-5324
    CAS: 141799-76-0

    E-5324是一个强效的酰基辅酶A:胆固醇酰基转移酶(ACAT)抑制剂，其IC50值在44至190nM之间。

  • GC31551 structure
    GC31551FR-190809
    CAS: 215589-63-2

    FR-190809是一种有效、可口服、无肾上腺毒性的酰基辅酶A-胆固醇酰基转移酶(ACAT)抑制剂，IC50值为45nM。

  • GC31553 structure
    GC315533b-Hydroxy-5-cholenoic acid
    CAS: 5255-17-4
    纯度: >99.00%

    A bile acid