GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC31555 structure
    GC31555MGAT2-IN-2
    CAS: 1710630-11-7

    MGAT2-IN-2是一种有效的选择性酰基辅酶A:单酰甘油酰基转移酶2(MGAT2)抑制剂，IC50为3.4nM。

  • GC31556 structure
    GC31556RPR107393 free base
    CAS: 197576-78-6

    RPR107393freebase是一种有效的选择性角鲨烯合酶(squalenesynthase)抑制剂，抑制鼠肝微粒体角鲨烯合成酶，IC50值为0.8±0.2nM。

  • GC31559 structure
    GC31559Thymine
    CAS: 65-71-4
    纯度: >99.50%

    Thymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA.

  • GC31562 structure
    GC31562Guanylic acid (5'-GMP)
    CAS: 85-32-5

    Guanylic acid (5'-GMP)是一种重要的核苷酸类化合物，是RNA的组成成分。

  • GC31564 structure
    GC31564BAY-85-8501
    CAS: 1161921-82-9
    纯度: >99.50%

    BAY-85-8501是人类中性脂酶(HNE)的一个有效的、选择性抑制剂，其IC50值为65pM。

  • GC31569 structure
    GC315693-Amino-2-methylpropanoic acid
    CAS: 144-90-1
    纯度: >98.00%

    3-Aminoisobutyric acid (3-Amino-2-methylpropanoic acid, 3-Aminoisobutyrate, β-aminoisobutyric acid) is a product formed by the catabolism of thymine.

  • GC31570 structure
    GC31570Tiglyl carnitine
    CAS: 64681-36-3

    Tiglylcarnitine被发现和乳糜泻，线粒体乙酰辅酶A硫代酶(T2)缺乏症有关。

  • GC31571 structure
    GC31571Isomaltose (6-O-α-D-Glucopyranosyl-D-glucose)
    CAS: 499-40-1
    纯度: >99.50% / >98.00% / >99.00%

    Isomaltose (6-O-α-D-Glucopyranosyl-D-glucose)是一种与麦芽糖相似的二糖，其连接方式为α-(1-6)连接，而麦芽糖的连接方式为α-(1-4)连接。

  • GC31572 structure
    GC31572Octanedioic acid
    CAS: 505-48-6

    Octanedioic acid (Suberic acid) is a dicarboxylic acid used in drug syntheses and plastics manufacture.

  • GC31574 structure
    GC31574Undecanedioic acid
    CAS: 1852-04-6
    纯度: >98.00%

    Undecanedioic acid (1,9-Nonanedicarboxylic acid, Undecanedionate) is a long-chain dicarboxylic acid that has applications in corrosion inhibitors, hot melt adhesives, high performance polyamides/Nylon, and more.

  • GC31575 structure
    GC31575Porphobilinogen
    CAS: 487-90-1

    Porphobilinogen可以作为一种光毒素，神经毒素和代谢毒素。

  • GC31576 structure
    GC31576Glycodeoxycholate Sodium (Sodium glycyldeoxycholate)
    CAS: 16409-34-0

    Glycochenodeoxycholic acid (GCDC, Glycodeoxycholate, Deoxycholylglycine) is a bile salt that is used as an anionic detergent to solubilize lipids.

  • GC31581 structure
    GC31581Pyridoxylamine
    CAS: 85-87-0
    纯度: >99.50%

    Pyridoxylamine是糖基化终产物(AGE)和脂质化终产物(ALE)抑制剂，可防止糖尿病引起的视网膜血管病变。

  • GC31583 structure
    GC31583SQ28603 (SQ28,603)
    CAS: 100845-83-8

    SQ28603 (SQ28,603) 是中性肽链内切酶 3.4.24.11 (NEP) 的有效选择性抑制剂，NEP 是一种降解心房利钠肽 (ANP) 的酶。

  • GC31584 structure
    GC31584Indole-3-carboxylic acid
    CAS: 771-50-6
    纯度: >99.50%

    A plant metabolite with diverse biological activities

  • GC31587 structure
    GC31587L-Homocitrulline
    CAS: 1190-49-4

    An amino acid and a product of carbamylation

  • GC31588 structure
    GC31588L-Hexanoylcarnitine
    CAS: 22671-29-0

    L-Hexanoylcarnitine是一种酰基肉碱，被发现和乳糜泻有关。

  • GC31590 structure
    GC31590Cholestenone
    CAS: 601-57-0
    纯度: >98.00%

    A cholesterol metabolite

  • GC31594 structure
    GC31594DL-O-Phosphoserine
    CAS: 17885-08-4

    DL-O-Phosphoserine是人类生物流体中的正常代谢物，是丝氨酸和磷酸的酯。

  • GC31595 structure
    GC315953-Methylbutanoic acid
    CAS: 503-74-2

    3-Methylbutanoic acid (Isovaleric acid, Delphinic acid, 3-Methylbutyric acid, Isopentanoic acid, β-methylbutyric acid) is a natural fatty acid found in a wide variety of plants and essential oils. It has a strong pungent cheesy or sweaty smell, but its volatile esters have pleasing scents and are used widely in perfumery.

  • GC31602 structure
    GC31602Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid)
    CAS: 28874-58-0
    纯度: >99.00%

    A naturally- occurring PUFA formed through elongation of arachidonic acid

  • GC31603 structure
    GC31603Delta-Tocopherol
    CAS: 119-13-1
    纯度: >98.50%

    A biologically active form of vitamin E

  • GC31605 structure
    GC31605N-Isovaleroylglycine
    CAS: 16284-60-9

    A urinary metabolite of leucine

  • GC31606 structure
    GC31606Docosanoic acid
    CAS: 112-85-6
    纯度: >95.00%

    A long-chain saturated fatty acid