GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC31608 structure
    GC31608Candoxatril (UK 79300)
    CAS: 123122-55-4

    Candoxatril (UK 79300) 是一种中性肽链内切酶 (NEP) 抑制剂。

  • GC31609 structure
    GC31609Glutarylcarnitine
    CAS: 102636-82-8

    Glutarylcarnitine丙二酸尿症和I型戊二酸尿症的重要诊断代谢物。

  • GC31610 structure
    GC316101-Methyluric acid
    CAS: 708-79-2
    纯度: >98.00%

    1-甲基尿酸是人体三种主要的茶碱代谢物之一。1-甲基尿酸是尿路结石中的嘌呤成分之一。甲基化嘌呤来源于甲基黄嘌呤（咖啡因、茶碱和可可碱）的代谢。作用于膀胱黏膜，并能增加血糖，胰岛素，甘油三酯和胆固醇的水平。

  • GC31611 structure
    GC316112-Phenylpropionic acid
    CAS: 492-37-5
    纯度: >99.00%

    2-Phenylpropionic acid (2-Phenylpropionate, Hydratropic acid, α-methyl-α-toluic acid) is an intermediate in alpha-Methylstyrene (2-phenylpropylene) metabolism.

  • GC31612 structure
    GC31612Thiamine pyrophosphate
    CAS: 154-87-0
    纯度: >99.50%

    A metabolite of vitamin B 1

  • GC31617 structure
    GC316177-Methylxanthine
    CAS: 552-62-5
    纯度: >98.50%

    An adenosine A 1 receptor antagonist and active metabolite of theobromine and caffeine

  • GC31619 structure
    GC31619Decanedioic acid
    CAS: 111-20-6

    Sebacic acid (1,8-Octanedicarboxylic acid) is a saturated, straight-chain naturally occurring dicarboxylic acid

  • GC31620 structure
    GC31620L-(-)-Fucose
    CAS: 2438-80-4
    纯度: >98.00%

    A monosaccharide important for immune function

  • GC31622 structure
    GC31622(S)-2-Hydroxysuccinic acid
    CAS: 97-67-6
    纯度: >98.00%

    (S)-2-Hydroxysuccinic acid (L-Malic acid), is a naturally occurring isomer of malic acid, found mainly in sour and unripe fruits.

  • GC31624 structure
    GC31624D-Xylulose
    CAS: 551-84-8

    A ketopentose

  • GC31625 structure
    GC316253-(3-Methoxyphenyl)propionic acid
    CAS: 10516-71-9
    纯度: >98.50%

    3-(3-Methoxyphenyl)propionic acid is a naturally occurring human metabolite, It is an organic acid and excreted in human urine.

  • GC31626 structure
    GC31626Bovinic acid
    CAS: 2540-56-9
    纯度: >99.00% / >98.00%

    Bovinic acid是一种共轭亚油酸，是一种在天然食物（特别是反刍动物制品）中存在的十八碳二烯酸。

  • GC31630 structure
    GC31630(S)-2-Hydroxy-3-phenylpropanoic acid
    CAS: 20312-36-1
    纯度: >99.50%

    (S)-2-Hydroxy-3-phenylpropanoic acid (L-(-)-3-Phenyllactic acid, (2S)-2-Hydroxy-3-phenylpropanoic acid) is a valuable building block in the pharmaceutical and chemical industry—has recently emerged as an important monomer in the composition of the novel degradable biocompatible material of polyphenyllactic acid.

  • GC31632 structure
    GC316322-Furoic acid (Furan-2-carboxylic acid)
    CAS: 88-14-2
    纯度: >98.00%

    2-Furoic acid (2-Furancarboxylic acid, Pyromucic acid, 2-Carboxyfuran, α-furancarboxylic acid, α-furoic acid) is an organic compound most widely found in food products as a preservative and a flavoring agent.

  • GC31636 structure
    GC31636Cholesteryl linoleate
    CAS: 604-33-1

    A cholesterol ester

  • GC31637 structure
    GC31637Docosapentaenoic acid 22n-3
    CAS: 24880-45-3
    纯度: >98.00%

    Docosapentaenoic acid 22n-3 (n-3 DPA)是EPA的延长代谢产物，是二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）之间的中间产物。

  • GC31640 structure
    GC316404-(1,2-Dihydroxyethyl)benzene-1,2-diol
    CAS: 28822-73-3
    纯度: >95.00%

    An active metabolite of norepinephrine

  • GC31641 structure
    GC31641Suberylglycine
    CAS: 60317-54-6

    A glycine-conjugated form of suberic acid

  • GC31646 structure
    GC31646NIM811 ((Melle-4)cyclosporin)
    CAS: 143205-42-9
    纯度: >98.50%

    NIM811 ((Melle-4)cyclosporin) ((Melle-4)cyclosporin; SDZ NIM811 ((Melle-4)cyclosporin)) 是一种口服生物可利用的线粒体通透性转换和亲环素双重抑制剂，在体外对丙型肝炎病毒具有有效的活性(丙肝病毒)。

  • GC31672 structure
    GC31672Tetrahydrobiopterin (Sapropterin)
    CAS: 17528-72-2
    纯度: >99.50%

    四氢生物蝶呤 (Sapropterin) ((Rac)-Sapropterin) 是芳香族氨基酸羟化酶的辅助因子，也是所有一氧化氮合酶 (NOS) 同种型的必需辅助因子。

  • GC31682 structure
    GC31682Mito-TEMPO
    CAS: 1334850-99-5
    纯度: >98.00%

    Mito-Tempo 是一种靶向线粒体的抗氧化剂，具有有效的超氧化物清除特性，可将有毒的超氧化物分子转化为过氧化氢或氧气，随后通过过氧化氢酶或谷胱甘肽过氧化物酶解毒为氧气和水 .在体外，Mito-Tempo 通过增强超氧化物歧化酶 (SOD) 活性和 PI3K/AKT/mTOR 磷酸化而具有更强的保护作用。

  • GC31700 structure
    GC31700Tuftsin
    CAS: 9063-57-4
    纯度: >98.50%

    A phagocytosis-stimulating peptide

  • GC31707 structure
    GC31707Chebulagic acid
    CAS: 23094-71-5
    纯度: >98.00%

    A polyphenol with diverse biological activities

  • GC31716 structure
    GC31716UK-371804
    CAS: 256477-09-5
    纯度: >98.00%

    A uPA inhibitor