Bovinic acid is a conjugated linoleic acid, an octadecadienoic acid found in natural foods, particularly ruminant products[1]. Bovinic acid is a potential bioactive component with activities such as anti-oxidative stress, anti-cancer, anti-diabetic, and anti-atherosclerotic effects[2, 3, 4]. Adding Bovinic acid to milk has a protective effect on colitis mice by activating the colonic nuclear factor-associated factor 2 (Nrf2) pathway[5].
In vivo, oral administration of Bovinic acid (100mg/kg) to mice with alcoholic liver disease (ALD) for 10 days significantly reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, decreased malondialdehyde (MDA) levels in liver tissue, and improved liver morphology[4].
References:
[1] Indu B, Jayaprakasha H M. Conjugated Linoleic Acid-The Natural Trans Fat: A Review[J]. Asian Journal of Dairy & Food Research, 2021, 40(4).
[2] Lock A L, Bauman D E. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health[J]. Lipids, 2004, 39(12): 1197-1206.
[3] Ayadi M, Hammadi M, Casals R, et al. Influence of management type and stage of lactation on the performance and milk fatty acid profile of dairy camels (Camelus dromedaries)[J]. The Journal of Agricultural Science, 2018, 156(9): 1111-1122.
[4] Dong Z, Zhang Z, Peng Y, et al. Pien Tze Huang ameliorates alcohol-associated liver disease by suppressing oxidative stress and ferroptosis through bovinic acid and taurine[J]. Beizi and Zhao, Mingrui and Gong, Maosheng and Wang, Guangji and Aa, Jiye and Hao, Haiping and Wang, Hong, Pien Tze Huang ameliorates alcohol-associated liver disease by suppressing oxidative stress and ferroptosis through bovinic acid and taurine.
[5] Bergamo P, Cocca E, Monaco A, et al. Protective effect of Rumenic acid rich cow's milk against colitis is associated with the activation of Nrf2 pathway in a murine model[J]. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2017, 125: 14-23.
Bovinic acid是一种共轭亚油酸，是一种在天然食物（特别是反刍动物制品）中存在的十八碳二烯酸[1]。Bovinic acid是潜在的生物活性成分，具有抗氧化应激、抗癌、抗糖尿病和抗动脉硬化等活性[2, 3, 4]。在牛奶中加入Bovinic acid对结肠炎小鼠具有保护作用，激活了结肠核因子相关因子2（Nrf2）通路[5]。
在体内，Bovinic acid（100mg/kg）通过口服治疗酒精性肝病（ALD）小鼠10天，显著降低了小鼠血清中丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）的水平，降低了肝脏组织中丙二醛（MDA）的水平，改善了肝组织形态[4]。