DL-3,4-Dihydroxyphenyl glycol is an active metabolite of the endogenous neurotransmitter norepinephrine .1 It is produced by the deamination of norepinephrine by monoamine oxidase (MAO) in the cytosol.2 DL-3,4-Dihydroxyphenyl glycol scavenges DPPH radicals in a cell-free assay (IC50 = 1.55 ?M).3 It reduces LPS-induced nitrite production in isolated mouse peritoneal macrophages when used at concentrations of 50 and 100 ?M. DL-3,4-Dihydroxyphenyl glycol (50 and 100 ?M) decreases increases in inducible nitric oxide synthase (iNOS) and COX-2 levels induced by LPS in isolated mouse macrophages. It also inhibits LPS-induced degradation of IκBα in isolated mouse macrophages.
1.Jonason, J., and Rutledge, C.O.The effect of protriptyline on the metabolism of dopamine and noradrenaline in rabbit brain in vitroActa Physiol. Scand.73(1)161-175(1968) 2.Padala, N.S.P., Ajjala, D.R., Boggavarapu, R.K., et al.LC-MS/MS method for quantification of 3,4-dihydroxyphenylglycol, a norepinephrine metabolite in plasma and brain regionsBioanalysis11(10)971-986(2019) 3.Aparicio-Soto, M., Sánchez-Fidalgo, S., González-Benjumea, A., et al.Naturally occurring hydroxytyrosol derivatives: Hydroxytyrosyl acetate and 3,4-dihydroxyphenylglycol modulate inflammatory response in murine peritoneal macrophages. Potential utility as new dietary supplementsJ. Agric. Food Chem.63(3)836-846(2015)