L-(-)-Fucose is a deoxyhexose monosaccharide found on N- and O-linked glycans and glycolipids of a wide variety of organisms.1 It can exist as a terminal modification of glycan structures or serve as a point of attachment for adding other sugars.2 In humans, L-(-)-Fucose plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions.1
1.Becker, D.J., and Lowe, J.B.Fucose: biosynthesis and biological function in mammalsGlycobiology13(7)41R-53R(2003) 2.Moloney, D.J., and Haltiwanger, R.S.The O-linked fucose glycosylation pathway: Identification and characterization of a uridine diphosphoglucose: Fucose-β1,3-glucosyltransferase activity from Chinese hamster ovary cellsGlycobiology9(7)679-687(1999)