Hexacosanoic acid is a 26-carbon saturated (26:0) very-long-chain fatty acid. Plasma levels of hexacosanoic acid are increased in a mouse model of adrenoleukodystrophy, a peroxisomal disorder.1 Increased levels of hexacosanoic acid in red blood cells or in plasma positively correlated with atherosclerotic risk factors and metabolic syndrome, respectively.2,3
1.Kobayashi, T., Shinnoh, N., Kondo, A., et al.Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolismBiochem. Biophys. Res. Commun.232(3)631-636(1997) 2.Antoku, Y., Tsukamoto, K., Miyoshi, Y., et al.Correlations of elevated levels of hexacosanoate in erythrocyte membranes with risk factors for atherosclerosisAtherosclerosis153(1)169-173(2000) 3.Kume, A., Miyazaki, T., Kitamura, Y., et al.High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese menDiab. Res. Clin. Pract.80(2)259-264(2008)