Cholesteryl linoleate is a cholesterol ester found in LDL.1 Cholesteryl linoleate is transferred to the plasma membrane of macrophages and CHO cells expressing 15-lipoxygenase (15-LO) via LDL receptor-related protein (LRP), where it undergoes oxidation to form cholesteryl linoleate hydroperoxides . Cholesteryl linoleate expression increases 2.7-fold in Apob-lipoproteins in mice overexpressing the human ABCA1 reverse cholesterol transporter, directly correlating with increased levels of hepatic cholesterol and number of atherosclerotic lesions.2
1.Takahashi, Y., Zhu, H., Xu, W., et al.Selective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenaseBiochem. Biophys. Res. Commun.338(1)128-135(2005) 2.Joyce, C.W., Wagner, E.M., Basso, F., et al.ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosisJ. Biol. Chem.281(44)33053-33065(2006)