5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 117 and 60 nM for the human and mouse enzymes, respectively).1 It inhibits LPS-induced prostaglandin E2 production in mouse peritoneal cells (IC50 = 31 nM). In vivo, 5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
1.Kal?ic, F., Kolman, V., Ajani, H., et al.Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edemaChemMedChem15(15)1398-1407(2020)