UK-371804

目录号: GC31716纯度: >98.00%

A uPA inhibitor

Cas No.: 256477-09-5

规格	价格	库存	数量
5mg	¥1,071.00	现货	1
10mg	¥1,874.00	现货	1
50mg	¥5,801.00	现货	1
100mg	¥8,479.00	现货	1
10mM (in 1mL DMSO)	¥1,178.00	现货	1

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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例

Nature
641, 529–536 (2025)
Nature
628, 630–638 (2024)
Nature
632, 686–694 (2024)
Nature
618, 1017–1023 (2023)
Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
Science
387(6739) (2025)
Science
387(6734) (2025)
Cell Research
35, 97–116 (2025)
Cell Research
34, 683–706 (2024)
Cell Research
33, 273–287 (2023)
Cell Research
33, 546–561 (2023)
Cell Research
33, 904–922 (2023)
Cell Research
31, 1291–1307 (2021)

产品描述 Description

UK 371804 is an inhibitor of urokinase-type plasminogen activator (uPA; K_i = 10 nM).¹ It is 4,000- and 2,700-fold selective for uPA over tissue plasminogen activator (tPA) and plasmin, respectively. UK 371804 inhibits exogenous uPA in human chronic wound fluid (IC₅₀ = 0.89 μM). Topical administration of UK 371804 inhibits exogenous uPA activity in a porcine excisional wound model.

1.Fish, P.V., Barber, C.G., Brown, D.G., et al.Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidinesJ. Med. Chem.50(10)2341-2351(2007)

实验参考方法 Experimental Reference Method

Animal experiment:

Pigs: Two female pigs are subjected to eight excisional wounds. The wounds are dressed and treated daily for 10 days with either 1 mL of a 10 mg/mL formulation of UK-371804 in hydrogel vehicle, or hydrogel vehicle alone (control). On day 11 the animals are sacrificed, terminal blood samples are taken to assess any systemic exposure of the compounds, and the wounds are excised from the surrounding normal skin[1].

References:

[1]. Fish PV, et al. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号

256477-09-5

SMILES

CC(C(O)=O)(C)NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2NC(N)=N)=O

分子式

C₁₄H₁₆ClN₅O₄S

分子量

385.83 g/mol

溶解性

DMSO : 10 mg/mL (25.92 mM)

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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