Cyclopiazonic acid-13C20 is intended for use as an internal standard for the quantification of cyclopiazonic acid by GC- or LC-MS. Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50 = 0.6 µM).1,2 In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats.3 It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.
1.Seidler, N.W., Jona, I., Vegh, M., et al.Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulumJ. Biol. Chem.264(30)17816-17823(1989) 2.Uyama, Y., Imaizumi, Y., and Watanabe, M.Effects of cyclopiazonic acid, a novel Ca2+-ATPase inhibitor, on contractile responses in skinned ileal smooth muscleBrit. J. Pharmacol.106(1)208-214(1992) 3.Nishie, K., Cole, R.J., and Dorner, J.W.Toxicity and neuropharmacology of cyclopiazonic acidFood Chem. Toxicol.23(9)831-839(1985)