Thalidomide 4'-ether-alkylC6-amine

目录号: GC50528纯度: >98.50%
Thalidomide 4'-ether-alkylC6-amine 是一种合成的 E3 连接酶配体-接头偶联物,用于 PROTAC dTAG-13,FKBP12F36V 和 BET 的降解剂。

Thalidomide 4'-ether-alkylC6-amine
Cas No.: 2245697-88-3
规格价格库存数量操作
5mg¥117.00现货
1
10mg¥175.00现货
1
25mg¥288.00现货
1
50mg¥437.00现货
1
100mg¥608.00现货
1
250mg¥1,339.00现货
1
1g¥4,322.00现货
1

文献被引

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产品描述 Description

Functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a C6 alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D. This product has been recently renamed. The previous name for this product was Thalidomide - linker 4 PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Nabet et al (2018) The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 14 431 PMID:29581585 |Erb et al (2017) Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 543 270 PMID:28241139

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
2245697-88-3
SMILES
NCCCCCCOC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O.Cl
分子式
C19H23N3O5.HCl
分子量
409.86 g/mol
溶解性
Soluble in DMSO
保存条件
4°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至 37°C,然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备 RT,或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol