GlpBio

TRC-766

目录号: GC61347纯度: >99.50%
TRC-766是一种RTC-5(TRC-382)的阴性对照。TRC-766可结合蛋白磷酸酶2A(PP2A)，但不激活磷酸酶。
TRC-766
Cas No.: 1810734-44-1
规格价格库存数量操作
5mg¥1,980.00现货
1
10mg¥3,150.00现货
1
10mM (in 1mL DMSO)¥2,286.00现货
1
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文献被引

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    183(7):1867-1883 (2020)
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产品描述 Description

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase[1].

As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability[1].

[1]. Kimberly McClinch, et al. Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer. Cancer Res. 2018 Apr 15;78(8):2065-2080.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
1810734-44-1
SMILES
O=S(C1=CC=C(OC(F)(F)F)C=C1)(N(CCCN2C3=CC(Cl)=CC=C3CCC4=CC=CC=C42)C)=O
分子式
C25H24ClF3N2O3S
分子量
524.98 g/mol
溶解性
DMSO: 150 mg/mL (285.73 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol