Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC31725Arachidonic acid (Immunocytophyt)CAS: 506-32-1纯度: >98.00%
花生四烯酸Arachidonic acid 是一种必需的不饱和脂肪酸,存在于动物和人类脂肪中,也存在于肝脏、大脑和腺体器官中。
- GC31794Methyl vanillateCAS: 3943-74-6纯度: >99.00%
Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
- GC31853D-Panthenol (Dexpanthenol)CAS: 81-13-0纯度: >98.00%
D panthenol (Dexpanthenol, D-Panthenol, Pantothenol, Ilopan, D-Pantothenyl alcohol) is an alcoholic analogue of D-pantothenic acid and cholinergic agent.
- GC31882Tinoridine hydrochloride (Y-3642 hydrochloride)CAS: 25913-34-2纯度: >98.00%
Tinoridine hydrochloride (Y-3642) is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity.
- GC31947ICI 211965 (ZM-211965)CAS: 129424-08-4
ICI 211965 (ZM-211965) (ZM-211965) 是一种选择性和口服有效的 5-脂氧合酶 (5-LPO) 抑制剂。
- GC31978Lonapalene (RS4317)CAS: 91431-42-4纯度: >99.00%
Lonapalene (RS4317) (RS4317) 是一种局部有效的 5-脂氧合酶 (5-LO) 抑制剂。
- GC319975-Lipoxygenase-In-1CAS: 125235-15-6
5-Lipoxygenase-In-1是5-脂氧合酶抑制剂，来自专利EP331232A2，table4，化合物实例4.10。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC31725 | Arachidonic acid (Immunocytophyt) | 506-32-1 | >98.00% | |
花生四烯酸Arachidonic acid 是一种必需的不饱和脂肪酸,存在于动物和人类脂肪中,也存在于肝脏、大脑和腺体器官中。 | ||||
| GC31734 | S-methyl-KE-298 (M-2) | 143584-75-2 | - | |
S-methyl-KE-298 (M-2) 是 KE-298 的活性代谢物。 | ||||
| GC31794 | Methyl vanillate | 3943-74-6 | >99.00% | |
Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro. | ||||
| GC31801 | Enazadrem | 107361-33-1 | - | |
Enazadrem是有效的5-脂氧合酶(5-lipoxygenase)抑制剂，具有抗炎功效。 | ||||
| GC31813 | RWJ 63556 | 190967-35-2 | - | |
RWJ63556是一种可口服的COX-2selective/5-lipoxygenase抑制剂，具有抗炎活性。 | ||||
| GC31835 | S-2474 | 158089-95-3 | - | |
S-2474是COX-2和5-lipoxygenase的抑制剂，在人完整的细胞中，对COX-2和COX-1的IC50值分别为11nM和27μM，为一种非甾体抗炎药。 | ||||
| GC31853 | D-Panthenol (Dexpanthenol) | 81-13-0 | >98.00% | |
D panthenol (Dexpanthenol, D-Panthenol, Pantothenol, Ilopan, D-Pantothenyl alcohol) is an alcoholic analogue of D-pantothenic acid and cholinergic agent. | ||||
| GC31856 | Petesicatib | 1252637-35-6 | >98.50% | |
Petesicatib是一种cathepsinS抑制剂，可用于免疫疾病研究。 | ||||
| GC31862 | T-26c | 869296-13-9 | >98.00% | |
A selective inhibitor of MMP-13 | ||||
| GC31874 | Olutasidenib (FT-2102) | 1887014-12-1 | >99.00% | |
An inhibitor of mutant IDH1 | ||||
| GC31882 | Tinoridine hydrochloride (Y-3642 hydrochloride) | 25913-34-2 | >98.00% | |
Tinoridine hydrochloride (Y-3642) is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity. | ||||
| GC31886 | Chelidonic acid | 99-32-1 | - | |
A pyran with diverse biological activities | ||||
| GC31889 | ZK824859 | 2271122-53-1 | - | |
ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively. | ||||
| GC31898 | Histatin 5 | 115966-68-2 | - | |
Histatin 5可抑制基质金属蛋白酶MMP-2和MMP-9的活性，IC 50 值分别为0.57μM和0.25μM。 | ||||
| GC31938 | A-69412 | 123606-23-5 | - | |
A-69412是一种特异性的、亲水性5-脂氧合酶(5-LO)的可逆抑制剂。 | ||||
| GC31940 | Docebenone (AA 861) | 80809-81-0 | >99.00% | |
A 5-LO inhibitor | ||||
| GC31947 | ICI 211965 (ZM-211965) | 129424-08-4 | - | |
ICI 211965 (ZM-211965) (ZM-211965) 是一种选择性和口服有效的 5-脂氧合酶 (5-LPO) 抑制剂。 | ||||
| GC31961 | CMI977 (LDP977) | 175212-04-1 | - | |
CMI977 (LDP977) 是一种有效的 5-脂氧合酶 (5-LO) 抑制剂。 | ||||
| GC31967 | COX/5-LO-IN-1 | 154355-75-6 | - | |
COX/5-LO-IN-1是cylooxygenase和5-lipoxygenase的抑制剂，用于炎症性和过敏性疾病的研究。 | ||||
| GC31978 | Lonapalene (RS4317) | 91431-42-4 | >99.00% | |
Lonapalene (RS4317) (RS4317) 是一种局部有效的 5-脂氧合酶 (5-LO) 抑制剂。 | ||||
| GC31997 | 5-Lipoxygenase-In-1 | 125235-15-6 | - | |
5-Lipoxygenase-In-1是5-脂氧合酶抑制剂，来自专利EP331232A2，table4，化合物实例4.10。 | ||||
| GC32002 | Bunaprolast (U66858) | 99107-52-5 | - | |
Bunaprolast (U66858) (U66858) 是人类全血中产生 LTB4 的有效抑制剂。 | ||||
| GC32005 | ZD8321 | 182073-77-4 | - | |
ZD8321是人Neutrophilelastase(NE)的有效抑制剂，其Ki值为13±1.7nM。 | ||||
| GC32008 | Feretoside | 27530-67-2 | - | |
Feretoside是一种从杜仲树皮中提取的酚类化合物。它是HSP诱导剂，可作为细胞保护剂。 | ||||