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Home >> Signaling Pathways >> Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GC35793 D-(+)-Phenyllactic acid

    D-3-苯乳酸,D-3-Phenyllactic acid

     D-3-Phenyllactic acid is a chiral building block that is used in preparation of statine.
  3. GC35780 Cycloguanil

    环氯胍

     Cycloguanil hydrochloride, an active metabolite of proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
  4. GC35757 Cucurbitacin D

    葫芦素 D

     A triterpenoid with diverse biological activities
  5. GC35754 CTTHWGFTLC, CYCLIC CTTHWGFTLC, CYCLIC 是基质金属蛋白酶 MMP-2 和 MMP-9 的环肽抑制剂。
  6. GC35752 CS-722 Free base CS-722 Free base 是一种合成的中枢作用肌肉松弛剂，具有肌肉松弛活性和对脊髓反射的抑制作用。CS-722 Free base 可能通过抑制钠和钙电流来抑制海马培养物中的自发抑制性突触后电流和兴奋性突触后电流。
  7. GC35741 CPA inhibitor

    ALPHA-[[羟基(2-苯基乙酰)氨基]甲基]苯丙酸,Carboxypeptidase inhibitor

     CPA inhibitor是羧肽酶A（CPA）抑制剂。
  8. GC35740 CP-640186 hydrochloride

    盐酸CP-640186

     An ACC inhibitor
  9. GC35703 Citicoline

    胞磷胆碱; Cytidine diphosphate-choline; CDP-Choline; Cytidine 5'-diphosphocholine

    An intermediate in the synthesis of phosphatidylcholine
  10. GC35675 Chimonanthine

    蠟梅鹼,(-)-Chimonanthine

     Chimonanthine 是腊梅中的生物碱，抑制酪氨酸酶及酪氨酸酶相关蛋白 1 mRNA 的表达，抑制黑色素的形成。
  11. GC35625 CC0651

    4,5-二脱氧-5-(3',5'-二氯[1,1'-联苯]-4-基)-4-[(2-甲氧基乙酰基)氨基]-L-阿拉伯糖酸

     CC0651 是一种人Cdc34泛素结合酶变构抑制剂。CC0651 有效抑制 p27Kip1的泛素化，IC50 为 1.72 μM。
  12. GC35608 Carboxypeptidase G2 (CPG2) Inhibitor

    N-[[(4-甲氧基苯基)硫]羰基]-L-谷氨酸,CPG2 Inhibitor

     Carboxypeptidase G2 (CPG2) Inhibitor是羧肽酶G2（CPG2）抑制剂，具有抗癌活性。
  13. GC35541 Boldenone Undecylenate

    宝丹酮十一烯酸酯

     An Analytical Reference Standard
  14. GC35535 BMS-906024 BMS-906024 是一种口服有效，选择性的 γ 分泌酶 (gamma secretase) 抑制剂 (GSI)，GSIs 是一类小分子 Notch 抑制剂。BMS-906024 可阻止具有高口服生物利用度的所有四种 Notch 受体的激活，对于 Notch1，-2，-3 和 -4 受体，IC50s 分别为 1.6，0.7，3.4 和 2.9 nM。 BMS-906024 表现出针对多种人癌症异种移植物的广谱抗肿瘤活性。
  15. GC35528 Bivalirudin TFA

    三氟醋酸比伐卢定

     A thrombin inhibitor
  16. GC35521 Biotin sulfone

    生物素砜

     An oxidized form of biotin
  17. GC35511 BI-0252 BI-0252 是一种具有口服活性，选择性的 MDM2-p53 抑制剂，IC50 值为 4 nM。 BI-0252 可诱导异种移植小鼠 SJSA-1 的所有动物肿瘤消退，同时诱导肿瘤蛋白p53 (TP53) 靶基因和凋亡标志物。
  18. GC35510 BI 224436

    暂无

     BI 224436是一种新型的HIV-1非催化性位点整合酶抑制剂，对HIV-1实验室菌株的EC50值小于15 nM。
  19. GC35499 Bestatin trifluoroacetate

    乌苯美司三氟乙酸盐; Ubenimex trifluoroacetate

     An aminopeptidase inhibitor
  20. GC35494 Benzoyloxypaeoniflorin

    苯甲酰氧化芍药苷

     Benzoyloxypaeoniflorin 分离于 Paeonia suffruticosa 的根，是 tyrosinase 抑制剂，对蘑菇 tyrosinase 的 IC50为 0.453 mM。Benzoyloxypaeoniflorin 是 NF-κB 抑制剂，Benzoyloxypaeoniflorin 通过对血小板聚集和凝血的抑制作用，有助于改善血液循环。
  21. GC35476 BAY-678 racemate BAY-678 racemate 是 BAY-678 的消旋体。BAY-678 是具有口服生物活性的、高效的、选择性的、人中性粒细胞弹性蛋白酶(HNE) 的细胞渗透性抑制剂，其 IC50 值为 20 nM。BAY-678 也是被基因结构组学联盟 (SGC) 推荐的化学探针。
  22. GC35470 Batimastat sodium salt

    (2S,3R)-N-羟基-N'-[(2S)-1-甲基氨基-1-氧代-3-苯基丙-2-基]-3-异丁基-2-(噻吩-2-基硫甲基)丁二酰胺单钠盐,BB-94 sodium salt

     A potent broad spectrum inhibitor of MMPs
  23. GC35425 Atreleuton

    ABT-761; VIA-2291

     A 5-LO inhibitor
  24. GC35420 ATP

    腺苷三磷酸; Adenosine 5'-triphosphate

     ATP是代谢反应中底物激活的磷酸基供体，用于生物合成细胞内第二信使环状腺苷酸单磷酸（cAMP），并作为真正的细胞外信使介导细胞间通讯。
  25. GC35395 Arnicolide D

    山金车内酯 D

     A sesquiterpene lactone with anticancer activity
  26. GC35388 Aristolactam I

    马兜铃内酰胺,Aristololactam; Aristolactam

     Aristololactam I (AL-I) 是马兜铃酸I (AA-I) 的主要代谢产物，参与导致肾损伤的过程。Aristololactam I (AL-I) 直接损伤肾近端小管细胞，AL-I 的细胞毒性效力高于AA-I，并且这些分子的细胞毒性作用是通过 caspase-3 依赖性细胞凋亡介导。
  27. GC35384 Argatroban monohydrate

    阿加曲班一水合物; MD-805 monohydrate; MCI-9038 monohydrate; Argipidine monohydrate

     A thrombin inhibitor
  28. GC35379 Arachidic acid

    二十酸,Icosanoic acid

     A long-chain saturated fatty acid
  29. GC35377 Apratastat

    N-羟基-4-[[4-[(4-羟基-2-丁炔基)氧基]苯基]磺酰基]-2,2-二甲基-3-硫代吗啉甲酰胺,TMI-005

     Apratastat是一种口服活性、可逆的双重抑制剂，能够抑制肿瘤坏死因子-α转换酶（TACE；IC50=81.7ng/mL）和基质金属蛋白酶（MMPs）的活性。
  30. GC35369 Apigenin-7-glucuronide

    芹菜素-7-葡萄糖醛酸,Apigenin 7-O-glucuronide

     Apigenin-7-O-glucuronide (Apigenin-7-glucuronide) is the major flavonoid found in milk thistle. Apigenin 7-o-glucuronide inhibits tumor necrosis factor alpha (TNF-α) and total nitrite release in lipopolysaccharide-activated macrophages.
  31. GC35367 APG-115

    AA-115

     APG-115 (APG-115) 是一种具有口服活性的 MDM2 蛋白抑制剂，与 MDM2 蛋白结合，IC50 和 Ki 值分别为 3.8 nM 和 1 nM。 APG-115 阻断 MDM2 和 p53 的相互作用，并以 p53 依赖性方式诱导细胞周期停滞和细胞凋亡。
  32. GC35361 Antineoplaston A10

    3-苯基乙酰氨基-2,6-哌啶二酮

     Antineoplaston A10 is a naturally occurring substance in the human body that that can be potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer. The main ingredient active of antineoplaston A10 (Phenylacetylglutamine, PG) inhibits RAS and promotes apoptosis.
  33. GC35356 Angiotensin III TFA Angiotensin III (TFA) 是血管紧张素1 (AT1) 和 AT2 受体激动剂。
  34. GC35355 Angiotensin III Angiotensin III是血管紧张素1 (AT1) 和 AT2 受体激动剂。
  35. GC35339 Anandamide

    花生四烯酸乙醇胺

     Anandamide是一种来源于含花生四烯酸膜脂的内源性大麻素，通过结合并激活CB1和CB2大麻素受体以及香草素瞬时受体电位通道1（TRPV1）受体发挥作用。
  36. GC35321 Aminomalonic acid

    氨基丙二酸

     Aminomalonic acid (Aminomalonate, Aminopropanedioic acid) is an amino dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite.
  37. GC35320 Aminoadipic acid

    2-氨基己二酸水合物

     DL-2-Aminoadipic acid is an excitatory amino acid analogue, which functions as a glutamine synthetase inhibitor.
  38. GC35300 Aloin(mixture of A&B)

    芦荟苷

     An anthroquinone with diverse biological activities
  39. GC35295 Allopurinol riboside

    别嘌呤醇核糖苷

     A ribonucleoside
  40. GC35262 Afzelin

    阿福豆苷,Kaempferol-3-O-rhamnoside

     A polyphenolic glycoside flavone with diverse biological activities
  41. GC35261 Aflatoxin B1

    黄曲霉毒素B1

     黄曲霉毒素B1作为一类由曲霉属真菌产生的致癌真菌毒素，常导致人和动物发生肝细胞癌。
  42. GC35228 Aceglutamide

    乙酰谷酰胺; α-N-Acetyl-L-glutamine; N2-Acetylglutamine

     An acetylated form of L-glutamine
  43. GC35221 ABT-046

    反式-4-[4-(7-氨基吡唑并[1,5-A]嘧啶-6-基)苯基]环己烷乙酸

     ABT-046 是一种具有口服活性的选择性二酰基甘油酰基转移酶 1 (DGAT-1) 抑制剂，IC50 为 8 nM。
  44. GC35219 Abiraterone metabolite 1

    3β-OH-5α-Abi

     Abiraterone metabolite 1 是 abiraterone 的 5β-还原代谢物。Abiraterone 是一种甾体药物，可抑制 CYP17A1，阻断雄激素的合成，延长前列腺癌的生存期。
  45. GC35204 8-Hydroxyguanine

    2-氨基-6,8-二羟基嘌呤

     8-Hydroxyguanine是由活性氧物质产生的主要诱变前损伤。 它导致G-T和A-C置换。
  46. GC35168 5-O-Demethylnobiletin

    去甲基川陈皮素,5-Demethylnobiletin

     A flavonoid with diverse biological activities
  47. GC35166 5-Methylcytosine

    5-甲基胞嘧啶

     5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription.
  48. GC35159 5'-Guanylic acid disodium salt

    5'-鸟苷酸二钠

     A nucleotide
  49. GC35157 5'-GTP trisodium salt

    鸟苷-5'-三磷酸三钠盐

     5'-GTP trisodium salt是G蛋白信号传导的激活剂，也是DNA和RNA生物合成的高能核苷酸单体。
  50. GC35156 5-Amino-3H-imidazole-4-Carboxamide

    4-氨基-5-咪唑甲酰胺,5-Aminoimidazole-4-carboxamide; AICA

     4-Amino-5-imidazolecarboxamide is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides.
  51. GC35152 5,6-Dihydro-5-methyluracil

    二氢胸腺嘧啶,Dihydrothymine

     Dihydrothymine is an intermediate breakdown product of thymine.

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