GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC32012 structure
    GC32012D-Ribose(mixture of isomers)
    CAS: 50-69-1
    纯度: >98.00%

    D-ribose is a naturally occurring sugar involved in producing energy in the body and is also the structural basis of DNA and RNA.

  • GC32013 structure
    GC32013L-689502
    CAS: 138483-63-3

    L-689502是一个有效的HIV-1蛋白酶(HIV-lprotease)抑制剂，其IC50值为1nM。

  • GC32016 structure
    GC32016AE-3763
    CAS: 291778-77-3
    纯度: >98.00%

    AE-3763是基于多肽的人中性粒细胞弹性蛋白酶(humanneutrophilelastase)抑制剂，IC50值为29nM。

  • GC32035 structure
    GC32035AZD 4407 (ZD 4407)
    CAS: 166882-70-8

    AZD 4407 (ZD 4407) 是一种有效的 5-脂氧合酶抑制剂。

  • GC32037 structure
    GC32037Cholesteryl palmitate
    CAS: 601-34-3
    纯度: >98.00%

    A cholesterol ester

  • GC32038 structure
    GC32038PGS-IN-1 (KME-4)
    CAS: 102271-49-8
    纯度: >99.50%

    PGS-IN-1 (KME-4) 是一种有效的前列腺素合成酶 (PGS) 抑制剂，IC50 为 0.28 μM;也抑制 5-脂氧合酶，IC50 为 1.05 μM.

  • GC32060 structure
    GC32060Bictegravir (GS-9883)
    CAS: 1611493-60-7
    纯度: >99.50%

    Bictegravir (GS-9883) 是一种用于治疗人类免疫缺陷病毒1型（HIV-1）感染的整合酶链转移抑制剂（INSTI）。

  • GC32121 structure
    GC32121Leu-AMS
    CAS: 288591-93-5
    纯度: >99.00%

    Leu-AMS是亮氨酰-tRNA合成酶(LRS)的有效抑制剂，其IC50值为22.34nM且能够抑制细菌的生长。

  • GC32149 structure
    GC32149Aminoacyl tRNA synthetase-IN-1
    CAS: 219931-45-0
    纯度: >99.50%

    AminoacyltRNAsynthetase-IN-1是细菌中氨酰基tRNA合成酶(aaRS)的抑制剂。

  • GC32186 structure
    GC32186Puromycin (CL13900)
    CAS: 53-79-2
    纯度: {{1-12}>98.00%}

    Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

  • GC32215 structure
    GC32215Propylparaben (Propyl parahydroxybenzoate)
    CAS: 94-13-3
    纯度: >98.50%

    Propylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent.

  • GC32216 structure
    GC32216Squalene (Super Squalene)
    CAS: 111-02-4
    纯度: >98.00%

    A biosynthetic precursor to steroids

  • GC32294 structure
    GC322941-Kestose
    CAS: 470-69-9

    1-酮糖是一种在蔬菜中发现的三糖，由β-D-呋喃果糖组成，在 1 位和 2 位分别连接有 β-D-呋喃果糖和 α-D-吡喃葡萄糖残基，具有益生元和抗糖尿病活性

  • GC32305 structure
    GC32305ACH-806 (GS9132)
    CAS: 870142-71-5

    ACH-806 (GS9132) 是一种 NS4A 拮抗剂，可抑制丙型肝炎病毒 (HCV) 复制，EC50 为 14 nM。

  • GC32327 structure
    GC32327PNU-103017
    CAS: 166335-18-8

    PNU-103017是一种HIV蛋白酶抑制剂。

  • GC32359 structure
    GC32359Pyrrole-2-carboxylic acid
    CAS: 634-97-9
    纯度: >99.50%

    Pyrrole-2-carboxylic acid (2-Pyrrolecarboxylic acid) is a degradation product of sialic acids and a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase.

  • GC32366 structure
    GC32366GlyRS-IN-1
    CAS: 112921-11-6

    GlyRS-IN-1是甘氨酰tRNA合酶(GlyRS)的抑制剂来自专利WO2017066459A1。GlyRS-IN-1也可以抑制细菌的生长。

  • GC32372 structure
    GC32372PCL 016
    CAS: 98-98-6
    纯度: >99.50%

    Picolinic acid (PCL 016) is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function.

  • GC32387 structure
    GC32387Farnesol
    CAS: 4602-84-0
    纯度: >99.00%

    Farnesol是一种在自然界普遍存在的C15萜烯醇，是植物精油的组成部分，也是白色念珠菌的群体感应分子。

  • GC32391 structure
    GC32391Pyrogallol
    CAS: 87-66-1
    纯度: >99.50%

    A natural oxidant

  • GC32410 structure
    GC324105a-Pregnane-3,20-dione
    CAS: 566-65-4
    纯度: >98.00%

    A progesterone receptor agonist and progesterone metabolite

  • GC32428 structure
    GC32428Trans-Anethole ((E)-Anethole)
    CAS: 4180-23-8
    纯度: >99.50%

    A phenylpropanoid with antifungal and antioxidant activity

  • GC32437 structure
    GC32437HSF1A
    CAS: 1196723-93-9
    纯度: >99.00%

    HSF1A是热休克转录因子1（HSF1）的激活剂。

  • GC32442 structure
    GC32442BR351
    CAS: 960113-85-3

    BR351是可渗透血脑屏障的MMP抑制剂，抑制MMP2，MMP8，MMP9，MMP13的IC50分别为4，2，11，50nM。是正电子发射断层扫描成像活化MMP分子的潜在工具。