Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC35150 5,7,4'-Trimethoxyflavone
5,7,4'-三甲氧基黄酮
4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.
GC35139 4-Methylesculetin
4-甲基七叶亭
4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.
GC35135 4-Methoxycinnamic acid
4-甲氧基肉桂酸
4-Methoxycinnamic acid 是一种天然苯丙烷类化合物。
GC35134 4-Methoxybenzaldehyde
4-甲氧基苯甲醛
p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde), an extract from Pimpinella anisum seeds, exhibits antifungal activity against a number of yeast and mold strains in laboratory media, fruit purees and fruit juices.
GC35131 4-Hydroxycoumarin
4-羟基香豆素
A coumarin
GC35126 4-Hydroxyphenylpyruvic acid
4-羟苯基丙酮酸
4-Hydroxyphenylpyruvic acid (4-HPPA), an abundant colon metabolite of polyphenols, is a potent scavenger that suppresses levels of free radicals and cyclooxygenase-2 (COX-2) and contributes to reduced risk of colon cancer development.
GC35111 3-Epiursolic Acid
3-表熊果酸
A pentacyclic triterpenoid with diverse biological activities
GC35106 3-Dehydrotrametenolic acid
3-氢化去氢松苓酸

3-Dehydrotrametenolic acid，分离于茯苓菌核，是一种乳酸脱氢酶 (LDH) 抑制剂。3-Dehydrotrametenolic acid 促进体外脂肪细胞分化，在体内起胰岛素增敏剂的作用。3-Dehydrotrametenolic acid 诱导细胞凋亡，具有抗癌活性。
GC35095 2-Phospho-L-ascorbic acid trisodium salt
L-抗坏血酸-2-磷酸三钠盐; 2-Phospho-L-ascorbic acid trisodium

Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products.
GC35090 2-Hydroxy atorvastatin calcium salt
2-羟基阿托伐他汀钙盐
An active metabolite of atorvastatin
GC35081 25,26-Dihydroxyvitamin D3
25,26-二羟基维生素D3,25,26-Dihydroxycholecalciferol
25,26-Dihydroxyvitamin D3是维生素D3代谢物。
GC35079 24, 25-Dihydroxy VD2
24,25-二羟基维他命 D2; 24,25-Dihydroxy vitamin D2
24, 25-Dihydroxy VD2 是一种维生素D2的羟基化代谢产物，是合成的维生素D类似物。
GC35075 20-HETE
20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸

A cytochrome P450 (CYP450) metabolite of arachidonic acid
GC35068 1-Monomyristin
1-肉豆蔻酸单甘油酯
A monoacylglycerol
GC35067 1-Methylguanosine
1-甲基鸟酐
A methylated purine nucleoside
GC35061 18α-Glycyrrhetinic acid
18-α-甘草次酸
Glycyrrhetinic acid is a triterpenoid aglycone component of the natural product glycyrrhizinic acid and possesses remarkable anti-proliferative and apoptosis-inducing activity in various cancer cell lines.
GC35058 16-Dehydroprogesterone
16-去氢黄体酮
16-Dehydroprogesterone is a chemical derived from a progesterone.
GC35039 1,4-Diaminobutane dihydrochloride
1,4-丁二胺二盐酸盐,Putrescine dihydrochloride
1,4-Diaminobutane (Putrescine, Tetramethylenediamine, 1,4-Butanediamine) is used as a precursor in many biological systems and synthon for amido-ureas.
GC35029 1-Arachidoyl-sn-glycero-3-phosphocholine 1-Arachidoyl-sn-glycero-3-phosphocholine是一种溶血磷脂 (LyP)。
GC35003 (S)-Nornicotine
3-(吡咯烷-2-基)吡啶
(S)-Nornicotine 是尼古丁的代谢物。
GC34961 (±)-BI-D
人BH3结构域凋亡诱导蛋白(BID)ELISA试剂盒
(_plusmn_)-BI-D是HIV整合酶（integrase）变构抑制剂，作用于整合酶与LEDGF/p75结合部位。
GC34951 (-)-Menthol
L-薄荷醇
A monoterpene with diverse biological activities
GC45252 (-)-Sitagliptin Carbamoyl Glucuronide
BETA-D-吡喃葡萄糖醛酸1-[N-[(1R)-3-[5,6-二氢-3-(三氟甲基)-1,2,4-三唑并[4,3-A]吡嗪-7(8H)-基]-3-氧代-1-[(2,4,5-三氟苯基)甲基]丙基]氨基甲酸酯]
A minor phase II metabolite of (–)-sitagliptin
GC45245 (-)-Caryophyllene oxide
石竹素,(-)-Caryophyllene oxide
A bicyclic sesquiterpene
GC45226 β-BHC
β-HCH, β-Hexachlorocyclohexane, β-Lindane
β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane.
GC45208 α-hydroxy Metoprolol
Α-羟基美托洛尔
An active metabolite of metoprolol
GC45204 α-Ecdysone
蜕皮激素; α-Ecdysone

蜕皮激素（α-蜕皮激素）是一种存在于昆虫和植物中的类固醇蜕皮激素，可激活盐皮质激素受体（MR），从而导致肾小球疾病。
GC45193 Z-YVAD-CMK (trifluoroacetate salt)
Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone, Caspase-1 Inhibitor IV
An inhibitor of caspase-1 and caspase-3
GC45192 Z-VRPR-FMK (trifluoroacetate salt)
Z-Val-Arg-Pro-DL-Arg-FMK
An irreversible inhibitor of MALT1
GC45189 Z-VAD(OH)-FMK
Z-VAD(OH)-FMK
Z-VAD(OH)-FMK是所有半胱天冬酶的不可逆三肽抑制剂。
GC45179 Zeaxanthin
玉米黄素
Zeaxanthin是一种具有多种生物活性的类胡萝卜素色素，存在于多种水果和蔬菜中，可以帮助治疗或预防与年龄相关的黄斑变性、青光眼和白内障。
GC45178 Z-DEVD-CMK (trifluoroacetate salt)
Z-Asp-Glu-Val-Asp-CMK
An irreversible protease inhibitor
GC45177 Z-AEVD-FMK
Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone
A caspase-10 inhibitor
GC45175 YVAD-CHO (trifluoroacetate salt)
H-Tyr-Val-Ala-Asp-CHO
A caspase-1/ICE inhibitor
GC45151 Voriconazole N-oxide
伏立康唑N-氧化物
A major metabolite of voriconazole
GC45144 Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)
维达列汀羧基酸代谢物三氟醋酸盐
A major metabolite of vildagliptin
GC45137 Valproic Acid Acyl-D-Glucuronide
Valproic Acid Gluclonide
A metabolite of valproic acid
GC45135 Validamycin A
井冈霉素
Validamycin A是一种通过抑制海藻糖酶（trehalase）保护作物免受真菌Rhizoctonia solani侵害的农用抗生素类杀菌剂，IC₅₀值为72μM。
GC45134 Valeryl-L-carnitine (chloride)
L-戊酰基肉碱,L-Valerylcarnitine
A short-chain acylcarnitine
GC45111 UDP-α-D-Glucose (sodium salt)
二磷酸尿苷葡萄糖二钠盐,UDP-D-Glucose disodium salt; Uridine 5′-diphosphoglucose disodium salt
A stereoisomer of UDP-α-D-glucose
GC45109 Ubiquinol
水溶型辅酶Q10
A reduced form of coenzyme Q₁₀
GC45090 Triparanol
曲帕拉醇,MER-29
An inhibitor of DHCR24
GC45086 Trigalacturonic Acid
半乳糖醛酸
三半乳糖醛酸是一种低聚糖，可抑制番茄植物中的蛋白酶活性（ED50 \u003d 2.6 μg/植物）。
GC45084 Tridecanoic Acid
十三酸; N-Tridecanoic acid
A 13-carbon saturated fatty acid
GC45066 Tosyl Phenylalanyl Chloromethyl Ketone
L-1,4'-甲基磺酰基-2-苯基乙基氯甲基酮,L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK
An inhibitor of chymotrypsin-like serine proteases
GC45031 Thiamine (hydrochloride)
Aneurine, Vitamin B1
Thiamine (hydrochloride)是一种水溶性必需微量营养素，Thiamine易透过血脑屏障，是研究能量代谢、神经炎症及衰老相关代谢功能障碍的重要工具化合物。
GC45024 tetranor-12(S)-HETE
tetranor-12(S)-Hydroxyeicosatetraenoic Acid
A peroxisome metabolite of 12(S)-HETE
GC45020 Tetrachlorohydroquinone
四氯氰醌
A metabolite of pentachlorophenol
GC45012 Tenofovir diphosphate (sodium salt)
PMPApp, TFV-DP
An HIV reverse transcriptase and HBV polymerase inhibitor
GC45007 Telmisartan Acyl-β-D-Glucuronide
(替米沙坦酰基)-Β-D-葡糖苷酸
A major metabolite of telmisartan