GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC32446 structure
    GC32446Vitamin K1 (Phylloquinone)
    CAS: 84-80-0
    纯度: >98.00%

    Vitamin K1 (Phylloquinone) 是一种脂溶性的、来源于植物的天然维生素。

  • GC32456 structure
    GC32456R-IMPP
    CAS: 2133832-83-2
    纯度: >99.00%

    A cell-permeable inhibitor of PCSK9 secretion

  • GC32457 structure
    GC32457Asymmetric dimethylarginine
    CAS: 30315-93-6
    纯度: >98.00%

    An endogenous NOS inhibitor

  • GC32470 structure
    GC32470Coenzyme Q9 (Ubiquinone Q9)
    CAS: 303-97-9
    纯度: >98.00%

    Coenzyme Q9 (Ubiquinone Q9)是一种具有9个异戊二烯单位的泛醌类化合物，作为电子传递链中的双亲分子组分，在内源性抗氧化和细胞能量代谢中发挥核心作用。

  • GC32482 structure
    GC32482Hydroxyhexamide ((±)-Hydroxyhexamid)
    CAS: 3168-01-2

    Hydroxyhexamide is a pharmacologically active metabolite of acetohexamide, which is a sulfonylurea hypoglycemic agent.

  • GC32483 structure
    GC324834,6-Dioxoheptanoic acid
    CAS: 51568-18-4
    纯度: >97.00%

    An inhibitor of δ-aminolevulinic acid dehydratase

  • GC32488 structure
    GC32488K-604 dihydrochloride
    CAS: 217094-32-1
    纯度: >98.00%

    K-604 dihydrochloride, a potent and selective inhibitor of Acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1), suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.

  • GC32489 structure
    GC32489Hemorphin-7
    CAS: 152685-85-3
    纯度: >99.50%

    Hemorphin-7是一种血啡肽(hemorphin)，是来源于血红蛋白β链的一种内源性阿片类物质。Hemorphin能够活化阿片类受体(opioidreceptor)以及抑制血管紧张素转化酶(angiotensin-convertingenzyme)，具有抗伤害、抗高血压的作用。

  • GC32499 structure
    GC32499Enalapril (MK-421)
    CAS: 75847-73-3

    Enalapril (MK-421)是一种具有口服活性的血管紧张素转换酶（ACE）抑制剂，在体内可迅速水解为活性代谢物Enalaprilat，Enalaprilat通过抑制血管紧张素II的生成，有效舒张血管，降低血压，并减轻心脏负荷。

  • GC32505 structure
    GC32505XL-784
    CAS: 1224964-36-6
    纯度: >98.00%

    XL-784是MMP的一个选择性抑制剂，其对MMP-1，MMP-3，MMP-8，MMP-9，MMP-13的IC50值分别约为1900，0.81，120，10.8，18，0.56nM。

  • GC32518 structure
    GC32518Norverapamil hydrochloride ((±)-Norverapamil hydrochloride)
    CAS: 67812-42-4
    纯度: >98.00%

    An L-type calcium channel blocker

  • GC32519 structure
    GC32519Vinburnine ((-)-Eburnamonine)
    CAS: 4880-88-0
    纯度: >99.50%

    Vinburnine ((-)-Eburnamonine, Vincamone, L-Eburnamonine) is a vasodilator. It is a vinca alkaloid and a metabolite of vincamine.

  • GC32520 structure
    GC32520Leucylarginylproline
    CAS: 133943-59-6

    Leucylarginylproline是血管紧张素转换酶(ACE)抑制剂，IC50值为0.27μM。

  • GC32534 structure
    GC32534Utibapril (FPL 63547)
    CAS: 109683-61-6

    Utibapril (FPL 63547) 是一种具有抗高血压活性的血管紧张素转换酶 (ACE) 抑制剂。

  • GC32535 structure
    GC32535Modecainide (BMY 40327)
    CAS: 81329-71-7

    Modecainide (BMY 40327) 是 Encainide 的主要代谢物，Encainide 是一种抗心律失常药物。

  • GC32544 structure
    GC32544Pivalopril (Pivopril)
    CAS: 81045-50-3

    Pivalopril (Pivopril) 是一种新型的口服活性血管紧张素转换酶 (ACE) 抑制剂。

  • GC32546 structure
    GC32546Prodipine hydrochloride
    CAS: 31314-39-3

    Prodipine是一种二苯基膦酸酯衍生物。抑制兔纯化的和血浆中的二肽基肽酶IV(DPPIV)，IC50分别为4.5μM和30μM。

  • GC32554 structure
    GC32554Inogatran (H-314-27)
    CAS: 155415-08-0

    Inogatran (H-314-27) (H-314-27) 是一种合成凝血酶抑制剂，用于治疗和预防动脉和静脉血栓性疾病。

  • GC32557 structure
    GC32557Rentiapril racemate (SA-446 racemate)
    CAS: 72679-47-1

    Rentiapril 外消旋体 (SA-446 racemate) (SA-446 racemate) 是 Rentiapril 的外消旋体。

  • GC32560 structure
    GC32560NCX899
    CAS: 690655-41-5

    NCX899是一种能够释放NO的enalapril的衍生物，能够抑制angiotensin-convertingenzyme(ACE)的活性。

  • GC32567 structure
    GC32567RWJ-445167 (3DP-10017)
    CAS: 226566-43-4

    RWJ-445167 (3DP-10017) (3DP-10017) 是凝血酶和因子 Xa 的双重抑制剂，Ki 分别为 4.0 nM 和 230 nM，具有有效的抗血栓形成活性。

  • GC32578 structure
    GC32578Docosatrienoic Acid (cis-13,16,19-docosatrienoic acid)
    CAS: 28845-86-5
    纯度: >99.00% / >98.00%

    A rare ω-3 fatty acid

  • GC32600 structure
    GC32600Imidaprilate (6366A)
    CAS: 89371-44-8

    Imidaprilate (6366A) 是 TA-6366 的活性代谢物，是一种有效的血管紧张素转换酶 (ACE) 抑制剂，IC50 为 2.6 nM，可用于高血压疾病的研究。

  • GC32604 structure
    GC32604Angiotensinogen (1-14), human
    CAS: 104180-23-6

    A synthetic peptide precursor of angiotensin I