GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC32608 structure
    GC326085-Amino-4-oxopentanoic acid
    CAS: 106-60-5
    纯度: >98.00%

    5-Amino-4-oxopentanoic acid是一种天然存在的非蛋白原性氨基酸，是光敏剂原卟啉IX（PpIX）的前药。5-Amino-4-oxopentanoic acid可以被波长约为635nm（580至740nm）的激光激活，发出红色荧光（620至710nm），作为多种癌症的光诊断剂。

  • GC32611 structure
    GC32611H-Ile-Pro-Pro-OH
    CAS: 26001-32-1

    A peptide ACE inhibitor

  • GC32613 structure
    GC32613RP-64477
    CAS: 135239-65-5
    纯度: >99.50%

    RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively.

  • GC32619 structure
    GC32619OM-189
    CAS: 55381-18-5

    OM-189是一种人工合成且有选择性的凝血酶抑制剂。

  • GC32620 structure
    GC32620Bimoclomol
    CAS: 130493-03-7
    纯度: >99.00%

    Bimoclomol是一种heatshockprotein(HSP)辅诱导剂，可用于心血管疾病的研究。

  • GC32628 structure
    GC32628ZD-0892
    CAS: 171964-73-1

    ZD-0892是选择性和有效的中性粒细胞弹性蛋白酶(neutrophilelastase)抑制剂，对于人嗜中性粒细胞弹性蛋白酶和猪胰弹性蛋白酶的Ki值分别为6.7和200nM。

  • GC32639 structure
    GC32639Thrombin inhibitor 1
    CAS: 855998-46-8

    Thrombininhibitor1是一种有效的凝血酶抑制剂(Ki=0.66nM，2xaPTT=0.43μM)。

  • GC32663 structure
    GC32663Desethyl KBT-3022
    CAS: 101001-72-3

    DesethylKBT-3022是新型抗血小板药物KBT-3022的主要活性代谢物。

  • GC32671 structure
    GC32671NEP-IN-2
    CAS: 145775-14-0

    NEP-IN-2是一种neutralendopeptidase抑制剂，主要用于研究动脉粥样硬化、再狭窄症的扩散等症状。

  • GC32694 structure
    GC32694GNE-140 racemate
    CAS: 1802977-61-2
    纯度: >98.00%

    GNE-140racemate是(R)-GNE-140和(S)-GNE-140的外消旋混合物。(R)-GNE-140是有效的乳酸脱氢酶A(LDHA)抑制剂。

  • GC32695 structure
    GC32695Ac-DEVD-CHO
    CAS: 169332-60-9
    纯度: >98.00%

    Ac-DEVD-CHO是一种Caspase-3抑制剂，IC 50 值为0.016μM。

  • GC32706 structure
    GC32706ND-646
    CAS: 1434639-57-2
    纯度: >98.50%

    An ACC inhibitor

  • GC32715 structure
    GC32715TOFA (RMI14514)
    CAS: 54857-86-2
    纯度: >99.50% / >98.00%

    TOFA (RMI14514)是乙酰辅酶A羧化酶-α (ACCA)的变构抑制剂。

  • GC32721 structure
    GC32721NSC232003
    CAS: 1905453-18-0
    纯度: >98.50% / >98.00%

    NSC232003是一种靶向UHRF1的小分子抑制剂。

  • GC32732 structure
    GC32732Hyaluronic acid
    CAS: 9004-61-9
    纯度: >97.00%

    透明质酸 (HA) 是由双糖的重复单元组成的生物聚合物，其中包括通过 β- (1 4) 和 β- (1 3) 糖苷连接的 D- 葡萄糖醛酸分子和 N- 乙酰氨基葡萄糖分子。

  • GC32737 structure
    GC32737TAK-243 (MLN7243)
    CAS: 1450833-55-2
    纯度: >98.00%

    TAK-243 (MLN7243)是一种选择性泛素活化酶（UBA1）抑制剂，IC 50 值为1nM。

  • GC32758 structure
    GC32758Isoginkgetin
    CAS: 548-19-6
    纯度: >99.50% / >98.00%

    Isoginkgetin是一种双黄酮类化合物，可抑制胰脂肪酶活性，IC 50 值为2.9µM。

  • GC32759 structure
    GC32759L-778123 hydrochloride (L-778,123 hydrochloride)
    CAS: 253863-00-2
    纯度: >98.50%

    A dual inhibitor of FTase and GGTase I

  • GC32792 structure
    GC32792JNJ0966
    CAS: 315705-75-0
    纯度: >99.00%

    An inhibitor of MMP-9 zymogen activation

  • GC32814 structure
    GC32814DKM 2-93
    CAS: 65836-72-8
    纯度: >98.00%

    DKM2-93是相对选择性的UBA5抑制剂，IC50值为430μM。

  • GC32823 structure
    GC32823Incyclinide (CMT-3)
    CAS: 15866-90-7
    纯度: >98.00%

    Incyclinide (CMT-3)是一种非抗生素，由四环素衍生的基质金属蛋白酶（MMP）抑制剂。

  • GC32838 structure
    GC32838BAY-2402234
    CAS: 2225819-06-5
    纯度: >99.00%

    A DHODH inhibitor

  • GC32858 structure
    GC32858ER-000444793
    CAS: 792957-74-5
    纯度: >98.00%

    ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening with IC50 of 2.8 μM.

  • GC32865 structure
    GC32865BMS-214662
    CAS: 195987-41-8
    纯度: >99.50%

    A potent FTase inhibitor