Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC45001 Tazarotenic Acid
他扎罗汀酸,AGN 190299
An active metabolite of tazarotene
GC44995 Taurodeoxycholic Acid (sodium salt)
牛磺脱氧胆酸钠
牛磺脱氧胆酸 (TDCA) 是一种胆汁盐，通常存在于肠腔内。
GC44992 Taurochenodeoxycholic Acid (sodium salt)
牛磺鹅去氧胆酸钠盐; 12-Deoxycholyltaurine sodium
Taurochenodeoxycholic Acid (sodium salt)是一种内源性亲水性胆汁酸，是由胆汁酸中的天然成分熊去氧胆酸（UDCA）在肝脏中与氨基酸牛磺酸进行化学结合形成的。Taurochenodeoxycholic Acid (sodium salt)已被批准用于治疗肝脏疾病。Taurochenodeoxycholic Acid (sodium salt)可以减少活性氧的形成，防止线粒体功能障碍，并降低细胞凋亡的阈值。
GC44990 Tanomastat
(S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸,BAY 12-9566
An inhibitor of MMP-2, -3, and -9
GC44982 T-2 Triol
T-2三醇
An active metabolite of T-2 toxin
GC44951 Stearoyl-L-carnitine (chloride)
C18 Carnitine
A long-chain acylcarnitine
GC44928 Sphingomyelins (from bovine spinal cord)
鞘磷脂
A sphingolipid
GC44917 Sorafenib N-oxide
索拉非尼N氧化物
An active metabolite of sorafenib
GC44913 Solifenacin N-oxide
索利那新N-氧化物
An inactive metabolite of solifenacin
GC44912 Solifenacin N-Glucuronide A metabolite of solifenacin
GC44908 sn-Glycerol-3-phosphate (cyclohexyl ammonium salt)
G3P
A lipid biosynthesis intermediate
GC44895 Sitagliptin N-Sulfate (sodium salt) A metabolite of (–)-sitagliptin
GC44891 Simeprevir (sodium salt)
西咪匹韦钠; TMC435 sodium; TMC435350 sodium
A potent NS3/4A protease inhibitor
GC44890 Silodosin Glucuronide (sodium salt)
赛洛多辛β-D-葡萄糖苷酸钠盐

An active metabolite of silodosin
GC44879 Sclerotiorin
核丛青霉素
A natural compound with LOX and CETP inhibitory activity
GC44874 Saxagliptin (hydrochloride)
沙克列汀中间体,BMS-477118 hydrochloride
A potent DPP-4 inhibitor
GC44867 SAICAR
Succino-AICAR
SAICAR是嘌呤核苷酸从头合成途径中的一种中间代谢产物，SAICAR能够以同工酶选择性的方式激活丙酮酸激酶M2亚型（PKM2；EC₅₀=0.3mM）。
GC44862 S3QEL-2 A suppressor of mitochondrial electron leak
GC44860 S1QEL1.1
S1QEL
A suppressor of I_Q electron leak
GC44820 Resveratrol-3-O-Sulfate (sodium salt) An active metabolite of resveratrol
GC44818 Resolvin D4
RvD4
A pro-resolving mediator
GC44815 Resolvin D1
17(S)-Resolvin D1, RvD1
A product of the action of 15- and 5-LO on DHA
GC44810 Reduced Haloperidol
还原氟哌啶醇
An active metobolite of haloperidol
GC44803 rac-7-hydroxy Propranolol (hydrochloride)
7-羟基普萘洛尔盐酸盐
An isomer and metabolite of propranolol
GC44799 Quinidine N-oxide A quinidine metabolite
GC44795 Miquelianin (Quercetin 3-O-glucuronide)
槲皮素3-O-葡萄糖酸苷,Quercetin 3-O-glucuronide; Quercetin 3-glucuronide
Miquelianin (Quercetin 3-O-glucuronide)是槲皮素在体内的主要代谢产物，也是羰基还原酶1（CBR1）的抑制剂。
GC44793 Pyrroloquinoline quinone
吡咯喹啉醌; PQQ; Methoxatin
据报道，吡咯并喹啉醌是一种新的哺乳动物乳酸脱氢酶 (LDH) 辅酶。
GC44785 Pyridoxal 5'-phosphate (hydrate)
3-羟基-2-甲基-5-磷酰氧甲基-4-吡啶甲醛,Pyridoxal phosphate hydrate
An enzyme cofactor
GC44699 Propranolol β-D-Glucuronide (sodium salt) A major metabolite of propranolol
GC44680 Pregnenolone sulfate (sodium salt)
3β-Hydroxy-5-pregnen-20-one monosulfate sodium
Pregnenolone sulfate (sodium salt)是一种孕烯醇酮的神经活性代谢产物，对氨基丁酸A型受体（GABA_AR）的IC₅₀值为26±2μmol/L，对不含γ亚基的GABA_AR的IC₅₀值为18±3μmol/L。
GC44676 Pravastatin lactone
普伐他汀类酯
A metabolite of pravastatin
GC44668 Posaconazole D-Glucuronide
Posaconazole N-β-D-Glucuronide
A metabolite of posaconazole
GC44665 PNU 142300
利奈唑胺杂质8
An inactive metabolite of linezolid
GC44659 PKSI-527 An inhibitor of plasma kallikrein
GC44650 Pitavastatin lactone
匹伐他汀内酯
A major phase 2 metabolite of pitavastatin
GC44635 Phosphoenolpyruvic Acid (potassium salt)
磷酸烯醇式丙酮酸钾; Potassium 1-carboxyvinyl hydrogenphosphate
An enzyme substrate for glycolysis and gluconeogenesis pathways
GC44628 Phenylephrine-3-O-Sulfate A metabolite of phenylephrine
GC44627 Phenylephrine Glucuronide
苯福林葡糖苷酸
A metabolite of phenylephrine
GC44599 Perindoprilat
培哚普利,S-9780
An active ACE inhibitor
GC44592 Pentacosanoic Acid
二十五烷酸
A saturated long-chain fatty acid
GC44581 PCTR3
Protein Conjugates in Tissue Regeneration 3
A specialized pro-resolving mediator
GC44580 PCTR2
Protein Conjugates in Tissue Regeneration 2
A specialized pro-resolving mediator
GC44579 PCTR1
Protein Conjugates in Tissue Regeneration 1
A specialized pro-resolving mediator
GC44555 Pantoprazole sulfone
泮托拉唑杂质A
A pantoprazole metabolite
GC44554 Pantoprazole Sulfide
泮托拉唑硫醚
A pantoprazole metabolite
GC44551 Palmitoyl-L-carnitine (chloride)
L-氯化棕榈酰肉碱
A long-chain acylcarnitine
GC44550 Palmitoyl-D-carnitine (chloride)
CAR 16:0, C16:0 Carnitine, D-Carnitine hexadecanoyl ester, D-Carnitine palmitoyl ester, D-Hexadecanoylcarnitine, Hexadecanoyl-D-carnitine, D-Palmitoylcarnitine
A long-chain acylcarnitine
GC44527 p,p'-DDE
2，2-双（4-氯苯基）-1，1-二氯乙烯,4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene
A metabolite and degradation product of the pesticide DDT
GC44509 Omeprazole sulfide
奥美拉唑硫醚,Ufiprazole
An intermediate for omeprazole synthesis
GC44506 Oligomycin D
芦他霉素,26-Demethyloligomycin A
An inhibitor of mitochondrial F₁F_O-ATPase