Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC44492 O-Desmethyl Metoprolol
O-去甲基美托洛尔
A major active metabolite of metoprolol
GC44490 Octanoyl-L-carnitine (chloride)
C8 Carnitine
A medium-chain acylcarnitine
GC44488 Octanoyl Coenzyme A (sodium salt)
Octanoyl-CoA
A medium-chain acyl CoA
GC44464 NSC 109555
DDUG, NCI C04808
An inhibitor of Chk2
GC44451 Norfluoxetine (hydrochloride)
去甲氟西汀,Desmethylfluoxetine
Norfluoxetine (hydrochloride)是Fluoxetine在肝脏中通过N-去甲基化产生的活性代谢物，具有口服活性。
GC44444 N-Oleoyl Valine A TRPV3 antagonist
GC44441 N-Oleoyl Leucine An N-acyl amide involved in mitochondrial uncoupling
GC44431 nNOS Inhibitor I
Neuronal Nitric Oxide Synthase, NOS I, ncNOS
A selective inhibitor of nNOS
GC44416 N-methyl Mesoporphyrin IX
N-甲基中卟啉IX

N-methyl Mesoporphyrin IX（NMM）是卟啉的过渡态类似物，是亚铁螯合酶的有效抑制剂，K_d值为7 nM。N-methyl Mesoporphyrin IX是G-四链体的特异性染色剂，激发/发射最大值分别为399/610 nm。
GC44415 N-methyl Leukotriene C4
Nmethyl LTC4

A stable LTC₄ mimetic
GC44409 Nivalenol
雪腐镰刀菌烯醇
A trichothecene mycotoxin
GC44358 Nebivolol O-β-D-Glucuronide An active metabolite of nebivolol
GC44353 NDMC101 A salicylanilide derivative
GC44351 N-Desmethyl Sildenafil (citrate) A major metabolite of sildenafil
GC44350 N-Desmethyl Sildenafil
N-去甲基西地那非,Desmethylsildenafil; UK-103,320
A major metabolite of sildenafil
GC44349 N-desmethyl Levofloxacin
左氧氟沙星相关物质A
An active metabolite of levofloxacin
GC44348 N-desmethyl Bendamustine
盐酸苯达莫司汀乙酯水解杂质
An active metabolite of bendamustine
GC44345 N-Desethyl Vardenafil
N-去乙基伐地那非
A vardenafil metabolite
GC44341 ND-336 A selective inhibitor of MMP-2, -9, and -14
GC44338 NCT-501 (hydrochloride) A reversible inhibitor of ALDH1A1
GC44308 NADP+ (sodium salt hydrate)
Β-烟酰胺腺嘌呤二核苷酸磷酸钠盐水合物
The oxidized form of NADPH
GC44307 NADP+
烟酰胺腺嘌呤双核苷酸磷酸盐,Coenzyme II, β-NADP, Nicotinamide adenine dinucleotide phosphate, TPN
NADP+ 是电子供体烟酰胺腺嘌呤二核苷酸磷酸的氧化形式。
GC44306 N-acetyl-S-geranylgeranyl-L-Cysteine
N-乙酰基-S-香叶基香叶基-L-半胱氨酸
A synthetic substrate for the SAM-dependent methyltransferase
GC44304 N-Acetyl-S-allyl-L-cysteine A primary metabolite of L-deoxyalliin
GC44299 N-Acetyl-4-benzoquinone imine
N-乙酰基-4-苯醌亚胺
A reactive CYP450 metabolite of acetaminophen
GC44295 N-acetyl Leukotriene E4
Nacetyl LTE4
The major inactive metabolite of LTE₄ found in bile
GC44294 N-acetyl Dapsone
N-乙酰氨苯砜
A metabolite of dapsone
GC44284 N1,N8-Diacetylspermidine (hydrochloride)
NSC 685959
An acetyl derivative of spermidine
GC44262 Myristoyl-L-carnitine (chloride)
L-Myristoylcarnitine
A long-chain acylcarnitine
GC44246 Moxifloxacin N-Sulfate (sodium salt) A metabolite of moxifloxacin
GC44237 MMP-9 Inhibitor I
Matrix Metalloproteinase-9 Inhibitor I
An inhibitor of MMP-9
GC44236 MMP-2/MMP-9 Inhibitor III (trifluoroacetate salt)
Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III
An inhibitor of MMP-2 and MMP-9
GC44214 ML-162 ML-162是一种可抑制谷胱甘肽过氧化物酶4（GPX4）的小分子化合物，IC₅₀值为1.42µM。
GC44212 MK-886 (sodium salt) A potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP)
GC44207 MitoTEMPOL A mitochondrial-targeting SOD mimetic
GC44206 MitoTEMPO (hydrate) A mitochondria-targeted antioxidant
GC44205 Mitoquinol
A mitochondria-targeted antioxidant
GC44204 MitoPQ
MitoParaquat

MitoPQ（MitoParaquat）是一种可选择性增加体内和细胞线粒体基质内超氧化物产生的线粒体靶向氧化还原循环剂。
GC44203 MitoPerOx A ratiometric fluorescent probe for mitochondrial lipid peroxidation
GC44202 MitoPBN A mitochondria-targeted antioxidant
GC44201 MitoP
MitoPhenol
The end product of a mitochondrial matrix H₂O₂ probe reaction
GC44199 MitoB
MitoBoronic Acid
A probe to detect H₂O₂ in mitochondria
GC44198 MitoA A probe to detect H₂S in mitochondria
GC44186 Metoclopramide (hydrochloride)
盐酸甲氧氯普胺
An orally bioavailable 5-HT₃ and D₂ receptor antagonist
GC44140 MCTR3
13-cysteinyl14-hydroxyDocosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 3, Maresin Sulfido Conjugate 3
A specialized pro-resolving mediator
GC44139 MCTR2
13-cysteinylglycinyl-14-hydroxy Docosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 2, Maresin Sulfido Conjugate 2
A specialized pro-resolving mediator
GC44138 MCTR1
13-glutathionyl-14-hydroxy Docosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 1, Maresin Sulfido Conjugate 1
A specialized pro-resolving mediator
GC44093 Lutein
叶黄素
Lutein是一种天然存在的类胡萝卜素，具有多种生物活性，广泛存在于绿叶蔬菜、玉米和蛋黄中。
GC44083 LP-533401
L-苯丙氨酸,4[2-AMINO-6-(3-[2,2,2-三氟-1-氟[1,1'-联苯-4-乙氧基])]-4-PYRIMIDINYL]—
An inhibitor of gut-derived serotonin biosynthesis
GC44079 L-Leucyl-L-Leucine methyl ester (hydrochloride)
LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride
L-Leucyl-L-Leucine methyl ester (hydrochloride)是一种溶酶体缩合产物，对自然杀伤细胞和CD4⁺及CD8⁺ T淋巴细胞具有细胞毒性，但不影响辅助性T细胞和B细胞。