GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC32869 structure
    GC32869HSP70-IN-1
    CAS: 1268273-90-0
    纯度: >98.00%

    HSP70-IN-1是一种热休克蛋白(HSP)抑制剂;抑制Kasumi-1细胞的生长的IC50值为2.3μM。

  • GC32873 structure
    GC32873VBY-825
    CAS: 1310340-58-9
    纯度: >99.50%

    VBY-825是cathepsin新型可逆抑制剂，对cathepsinB,L,S和V都具有很高的抑制力。

  • GC32881 structure
    GC32881Milademetan (DS-3032)
    CAS: 1398568-47-2
    纯度: >98.00%

    Milademetan (DS-3032) (DS-3032) 是一种特异性的、具有口服活性的 MDM2 抑制剂，用于研究急性髓性白血病 (AML) 或实体瘤。 Milademetan (DS-3032) (DS-3032) 诱导 G1 细胞周期停滞、衰老和凋亡。

  • GC32882 structure
    GC32882Upamostat (WX-671)
    CAS: 590368-25-5
    纯度: >98.00%

    Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system.

  • GC32904 structure
    GC32904Enasidenib mesylate (AG-221 mesylate)
    CAS: 1650550-25-6
    纯度: >99.50%

    An inhibitor of mutant IDH2

  • GC32911 structure
    GC32911CTX1
    CAS: 501935-96-2

    CTX1是一种新型小分子p53激活剂。

  • GC32931 structure
    GC32931LDH-IN-1
    CAS: 1964515-43-2
    纯度: >99.50%

    LDH-IN-1是一种新的基于吡唑的人乳酸脱氢酶(LDH)抑制剂，对于LDHA和LDHB的IC50值分别为32和27nM。

  • GC32938 structure
    GC32938S 3304
    CAS: 203640-27-1
    纯度: >99.00%

    S-3304是一个新型的基质金属蛋白酶(MMP)抑制剂,且对MMP-2和MMP-9有特异的抑制活性。

  • GC32943 structure
    GC329433-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid)
    CAS: 646-01-5
    纯度: >98.00%

    3-(Methylthio)propionic acid (3-methylthiopropionate, 4-Thiapentanoic acid, 3-Methylsulfanylpropionic acid) is a thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position and an intermediate in mammalian methionine metabolism in vitro.

  • GC32951 structure
    GC32951Prinomastat (AG3340)
    CAS: 192329-42-3

    An inhibitor of MMP-2, -3, -9, -13, and -14

  • GC32965 structure
    GC32965Ethoxyquin
    CAS: 91-53-2
    纯度: >98.00%

    An antioxidant used in animal feed

  • GC32966 structure
    GC32966Mutant IDH1-IN-2
    CAS: 1429176-69-1
    纯度: >98.50%

    MutantIDH1-IN-2是一种突变型异柠檬酸脱氢酶(IDH)蛋白抑制剂,在LS-MS生物化学检测中IC50值为<22nM,荧光生物化学检测中IC50值为16.6nM。

  • GC32993 structure
    GC32993(S)-GNE-140
    CAS: 2003234-64-6
    纯度: >99.00%

    (S)-GNE-140是活性较小的GNE-140的对映体，能够抑制乳酸脱氢酶A(LDHA)。

  • GC32998 structure
    GC32998Ginsenoside Rh4
    CAS: 174721-08-5
    纯度: >98.00%

    Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.

  • GC33007 structure
    GC33007Tipifarnib S enantiomer ((S)-(-)-R-115777)
    CAS: 192185-71-0

    An inactive enantiomer of tipifarnib

  • GC33039 structure
    GC33039COH000
    CAS: 1534358-79-6
    纯度: >98.00%

    An inhibitor of SUMO-activating enzyme

  • GC33047 structure
    GC33047SNX-5422 Mesylate (PF-04929113 (Mesylate))
    CAS: 1173111-67-5

    A prodrug for an Hsp90 inhibitor

  • GC33072 structure
    GC33072AZ7550
    CAS: 1421373-99-0

    An active metabolite of AZ 9291

  • GC33118 structure
    GC33118Compound E
    CAS: 209986-17-4
    纯度: >99.50%

    An inhibitor of γ- secretase

  • GC33140 structure
    GC33140N2,N2-Dimethylguanosine
    CAS: 2140-67-2
    纯度: >99.00%

    A methylated purine nucleoside

  • GC33164 structure
    GC33164PNU-248686A
    CAS: 341498-89-3

    PNU-248686A是一种新型的基质金属蛋白酶(MMP)抑制剂。

  • GC33219 structure
    GC33219NCT-505
    CAS: 2231079-74-4

    NCT-505是一种有效的，选择性的乙醛脱氢酶(aldehydedehydrogenase(ALDH1A1))抑制剂，IC50值为7nM，对hALDH1A2，hALDH1A3，hALDH2，hALDH3A1的抑制作用较弱，IC50值分别为>57，22.8，20.1，>57μM。

  • GC33274 structure
    GC33274Glutaminase-IN-1
    CAS: 2247127-79-1
    纯度: >98.00%

    Glutaminase-IN-1是CB839的一个衍生物，是1,3,4-硒二氮基肾型谷氨酰胺酶(KGA)的变构抑制剂，其IC50值为1nM.Glutaminase-IN-1具有提高细胞摄取和抗肿瘤的活性。

  • GC33286 structure
    GC33286TAS-116
    CAS: 1260533-36-5
    纯度: >99.00%

    An Hsp90 inhibitor