Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC44061 L-Homoarginine (hydrochloride)
L-高精氨酸盐酸盐
An uncompetitive inhibitor of alkaline phosphatases
GC44056 Leukotriene E4 methyl ester
LTE4 methyl ester
A more lipid soluble formulation of LTE₄
GC44055 Leukotriene D4 methyl ester A more lipid soluble formulation of LTD₄
GC44054 Leukotriene C4 methyl ester
LTC4 methyl ester
A more lipid soluble formulation of LTE₄
GC44053 Leukotriene B4 Ethanolamide
LTB4EA
A theoretical 5-LO metabolite of arachidonoyl ethanolamide
GC44052 Leukotriene B4 dimethyl amide
LTB4 dimethyl amide
A LTB₄ receptor antagonist
GC44044 Lauroyl-L-carnitine (chloride)
L-氯化月桂酰肉碱
月桂基-l-肉碱是一种天然存在的化合物，属于酰基肉碱家族。
GC44033 Lansoprazole sulfone
兰索拉唑磺酸盐
A metabolite of lansoprazole
GC44029 L-Alanyl-L-Glutamine
L-丙氨酸-L-谷氨酰胺
A synthetic glutamine dipeptide
GC44019 L-(+)-Ergothioneine
麦角硫因; L-(+)-Ergothioneine
L-(+)-Ergothioneine是一种含硫的组氨酸衍生物，是一种有效的抗氧化剂。
GC43922 Isovaleryl-L-carnitine (chloride)
L-异戊酰基肉碱
Isovaleryl-L-carnitine (chloride)是L-肉碱的类似物，可延迟小鼠C2.8肝细胞中起始的凋亡细胞死亡。
GC43912 Isoapoptolidin Isoapoptolidin is a stable derivative of apoptolidin that demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively).
GC43909 Iromycin A
6-[(2E,5E)-3,7-二甲基-2,5-辛二烯基]-4-羟基-3-甲基-5-丙基-2(1H)-吡啶酮
A natural eNOS inhibitor
GC43904 Inosine 5'-triphosphate (sodium salt)
三磷酸肌苷三钠盐
A nucleoside triphosphate
GC43903 Indoxyl Sulfate (potassium salt)
硫酸吲哚钾盐
硫酸吲哚酚(Indoxyl sulfate (IS)),又称3-吲哚酚硫酸和3-吲哚酚硫酸,是膳食l -色氨酸的代谢物,具有心脏毒素和尿毒症毒素的作用。
GC43901 Indole-3-Acetic Acid (sodium salt)
1H-吲哚-3-羧酸（吲哚乙酸）,Indole-3-acetic acid sodium; 3-IAA sodium
A plant growth regulator
GC43896 Iloperidone metabolite P95
伊潘立酮代谢物P95
A metabolite of iloperidone
GC43895 Iloperidone metabolite P88
伊潘立酮代谢物; P88; Hydroxy Iloperidone
An active metabolite of iloperidone
GC43887 IBTP (iodide) A mitochondria-targeting thiol reactive probe
GC43881 Hydroxy Varenicline
伐伦克林杂质
A metabolite of varenicline
GC43879 Hydroxy Ebastine An ebastine metabolite
GC43878 Hydroxy Dimetridazole
1-甲基-5-硝基-2-羟甲基咪唑,Hydroxy Dimetridazole
A metabolite of dimetridazole
GC43876 Hydroxy Bosentan
波生坦羟甲基杂质,Ro 48-5033
A metabolite of bosentan
GC43820 Hexadecanal
十六醛,Palmitaldehyde
A free fatty aldehyde analog of palmitic acid
GC43786 GS-143
4-(3-苄基-4-((5-(2-氟苯基)呋喃-2-基)亚甲基)-5-氧代-4,5-二氢-1H-吡唑-1-基)苯甲酸
An inhibitor of IκBα ubiquitylation
GC43780 GM 1489 An MMP inhibitor
GC43776 Glycochenodeoxycholic Acid (sodium salt)
甘氨鹅脱氧胆酸钠; Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate
A primary bile acid
GC43743 Gemfibrozil 1-O-β-Glucuronide
吉非罗齐酰基β-D-葡萄糖醛酸
A major metabolite of gemfibrozil
GC43729 Ganglioside GD3 Mixture (sodium salt)
双唾液酸神经节苷脂GD3; Disialosyllactosylceramide
A mixture of ganglioside G_D3
GC43725 Gallocyanine
花菁
A Dkk1 inhibitor
GC43723 Galactosylsphingosine (d18:1)
神经鞘氨醇半乳糖苷,Galactosylsphingosine
A bioactive sphingolipid
GC43714 Fura-FF AM
钙离子荧光探针FURA-FF,AM
A cell-permeable, low affinity fluorescent calcium indicator
GC43713 Fura-FF (potassium salt)
钙离子荧光探针FURA-FF,五钾盐
A low affinity fluorescent calcium indicator
GC43709 Fumonisin B2
伏马菌素B2
A mycotoxin
GC43697 Formoterol O-β-D-Glucuronide
福莫特罗杂质14
A metabolite of formoterol
GC43675 Florfenicol amine (hydrochloride)
氟苯尼考胺盐酸盐
A veterinary antibiotic metabolite
GC43664 Filipin II An active component of the filipin complex
GC43649 Falcarinol
人参炔醇; Panaxynol; Carotatoxin
Falcarinol是一种天然来源的口服Hsp90抑制剂。
GC43646 Ezetimibe Hydroxy Glucuronide
依泽替米贝羟基-b-D-葡萄糖醛酸
A minor phase II metabolite of ezetimibe
GC43616 EOS (d18:1/32:1/18:2)
C52:3 EOS (18:1/32:1(22 Z)w18:2(9Z,12Z), Esterified ω-hydroxyacyl Sphingosine
An essential ceramide for prevention of epidermal water loss
GC43611 Enniatin B1
恩镰孢菌素 B1
An antibiotic ionophore
GC43609 Enniatin A
镰孢菌素 A
A component of the enniatin complex
GC43582 Dynorphin B (1-9) (trifluoroacetate salt) A neuropeptide
GC43565 Doxorubicinol (hydrochloride)
13-Dihydroadriamycin hydrochloride
A doxorubicin metabolite
GC43543 DNP-INT An electron transport inhibitor in plants
GC43498 DL-α-Lipoic Acid
α-硫辛酸; Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid
An important decarboxylation cofactor and antioxidant
GC43493 DL-Sulforaphane N-acetyl-L-cysteine
SFNNAC
An anticancer agent
GC43490 DL-Glyceraldehyde-3-phosphate
DL-甘油醛3-磷酸
DL-甘油醛-3-磷酸是冬氨酸氨基转移酶阳离子和阴离子同工酶的一种时间依赖性抑制剂。
GC43463 DiIC1(5)
1,1',3,3,3',3'-六甲基吲哚双碳菁碘
DiIC1(5)是一种用于检测线粒体膜电位破坏的信号关闭型荧光探针，激发/发射波长分别为638nm和 675nm。
GC43459 Dihydro Montelukast
孟鲁司特钠二氢杂质
A potential impurity found in commercial montelukast preparations