GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC33309 structure
    GC33309ML132 (NCGC 00185682)
    CAS: 1230628-71-3
    纯度: >98.00%

    ML132 (NCGC 00185682) (NCGC-00183434) 是一种选择性 caspase 1 抑制剂，IC50 为 34.9 nM。

  • GC33318 structure
    GC33318Mutant IDH1-IN-4
    CAS: 1416270-18-2
    纯度: >99.00%

    MutantIDH1-IN-4(compound434)是一种突变型异柠檬酸脱氢酶1(IDH1)的抑制剂，其对R132H、HT1080和U87R132H细胞中的突变型IDH1的IC50值≤0.5μM。

  • GC33330 structure
    GC33330Cynaropicrin
    CAS: 35730-78-0
    纯度: >98.00%

    A sesquiterpene lactone

  • GC33333 structure
    GC33333Regorafénib N-oxyde M2
    CAS: 835621-11-9
    纯度: >99.50%

    Regorafénib N-oxyde M2是Regorafenib的一种活性代谢产物。

  • GC33356 structure
    GC33356AM-8735
    CAS: 1429386-01-5

    AM-8735是有效，选择性的MDM2抑制剂，IC50值为25nM。

  • GC33365 structure
    GC33365BR351 precursor
    CAS: 960113-89-7

    BR351precursor是BR351的前体。BR351是可渗透血脑屏障的MMP抑制剂，抑制MMP2，MMP8，MMP9，MMP13的IC50分别为4，2，11，50nM。是正电子发射断层扫描成像活化MMP分子的潜在工具。

  • GC33367 structure
    GC33367FTI 276
    CAS: 170006-72-1

    FTI-276是有效的proteinfarnesyltransferase(PFT)抑制剂,作用于恶性疟原虫和人类的IC50值分别为0.9和0.5nM。

  • GC33383 structure
    GC333833-Hydroxycapric acid
    CAS: 14292-26-3

    A hydroxy fatty acid

  • GC33426 structure
    GC33426Rocaglamide (Rocaglamide A)
    CAS: 84573-16-0
    纯度: >98.50%

    Rocaglamide (Rocaglamide A) 是从 Aglaia 属（楝科）中分离出来的。

  • GC33436 structure
    GC334363-Indoleacetic acid (Indole-3-acetic acid)
    CAS: 87-51-4
    纯度: >98.00% / >99.00% / >99.50%

    3-吲哚乙酸（Indole-3-乙酸）（Indole-3-乙酸）是生长素类中最常见的天然植物生长激素。

  • GC33438 structure
    GC33438Hydroxy Itraconazole
    CAS: 112559-91-8
    纯度: >99.50%

    A metabolite of itraconazole

  • GC33445 structure
    GC33445O-Acetylserine (O-Acetyl-L-serine)
    CAS: 5147-00-2
    纯度: >98.00%

    O-Acetylserine is an intermediate in the biosynthesis of the common amino acid cysteine in bacteria and plants.

  • GC33450 structure
    GC334507-Dehydrocholesterol
    CAS: 434-16-2
    纯度: >99.00%

    7-Dehydrocholesterol（7-DHC）是胆固醇和维生素D的前体，在皮肤暴露于紫外B（UVB）光时转化为维生素D 3 。7-Dehydrocholesterol是一种天然抗铁死亡代谢物，通过防止脂质过氧化来保护细胞，脂质过氧化是铁死亡的一个关键过程。

  • GC33452 structure
    GC33452Niraparib metabolite M1 (Niraparib carboxylic acid metabolite M1)
    CAS: 1476777-06-6
    纯度: >99.50%

    Niraparib 代谢物 M1 (Niraparib carboxy acid metabolite M1) 是 niraparib 的代谢物，后者作为一种新型聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂。

  • GC33455 structure
    GC33455N-Acetylornithine
    CAS: 6205-08-9

    An intermediate in arginine and proline metabolism

  • GC33459 structure
    GC33459delta-Valerobetaine
    CAS: 6778-33-2
    纯度: >98.00%

    Delta-Valerobetaine 是三甲胺 N-氧化物 (TMAO) 的前体。

  • GC33460 structure
    GC33460D-Mannose
    CAS: 3458-28-4
    纯度: >98.00%

    An aldohexose monosaccharide

  • GC33462 structure
    GC33462Phenylacetylglutamine (NSC 203800)
    CAS: 28047-15-6
    纯度: >98.00% / >97.00%

    Phenylacetylglutamine (NSC 203800)是氨基酸发酵产生的肠绞痛微生物代谢物，苯乙酰谷氨酰胺是氨基酸发酵产生的肠绞痛微生物代谢物，它来源于谷氨酰胺与苯乙酸的结合，苯乙酸几乎完全来自于微生物对苯丙氨酸的转化。

  • GC33463 structure
    GC334631-Methyladenosine
    CAS: 15763-06-1
    纯度: >98.00%

    1-甲基腺苷是一种在1 位带有甲基取代基的甲基腺苷。它具有作为人体代谢物的作用，在功能上与腺苷有关

  • GC33464 structure
    GC33464Oxyresveratrol (trans-Oxyresveratrol)
    CAS: 29700-22-9
    纯度: >98.50%

    A resveratrol analog

  • GC33471 structure
    GC33471p-Hydroxycinnamic acid (NSC 59260)
    CAS: 7400-08-0
    纯度: >99.50%

    p-Hydroxy-cinnamic Acid has in vitro antimalarial activity and in vivo anti-osteoporotic properties.

  • GC33484 structure
    GC33484Ampyrone (4-Aminoantipyrine)
    CAS: 83-07-8

    4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.

  • GC33495 structure
    GC33495N-Desmethyl imatinib
    CAS: 404844-02-6
    纯度: >98.00%

    A major active metabolite of imatinib

  • GC33496 structure
    GC334962-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine)
    CAS: 10030-78-1
    纯度: >97.00%

    2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) (N2-Methylguanine) 是一种修饰的核苷。