Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC33518N-Acetylputrescine hydrochlorideCAS: 18233-70-0纯度: >95.00% / >98.00%
N-Acetylputrescinehydrochloride是一种腐胺衍生物。
- GC335192,5-Dihydroxybenzoic acidCAS: 490-79-9纯度: >99.50%
A benzoic acid with diverse biological activities
- GC33532Norgestimate metabolite Norelgestromin (17-Deacetyl norgestimate)CAS: 53016-31-2纯度: >99.50%
An active metabolite of norgestimate
- GC33548Netupitant metabolite Netupitant N-oxide (Netupitant N-oxide)CAS: 910808-11-6
A metabolite of netupitant
- GC33558Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen)CAS: 37519-14-5纯度: >99.50% / >98.00%
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen)是一种稳定的、羟基化的对乙酰氨基酚中间体。
- GC33559Netupitant metabolite Monohydroxy Netupitant (Monohydroxy Netupitant)CAS: 910808-12-7
Monohydroxy Netupitant 是 Netupitant 的代谢物，Netupitant 是一种高选择性的 NK1 受体拮抗剂。
- GC33563Netupitant metabolite N-desmethyl Netupitant (N-desmethyl Netupitant)CAS: 290296-72-9
N-desmethyl Netupitant 是 Netupitant 的代谢物，Netupitant 是一种止吐药。
- GC33571Duloxetine metabolite Para-Naphthol Duloxetine (Para-Naphthol duloxetine)CAS: 949095-98-1
对萘酚度洛西汀是度洛西汀的代谢产物，度洛西汀是一种血清素去甲肾上腺素再摄取抑制剂 (SNRI)。
- GC33578Ivabradine metabolite N-Demethyl Ivabradine hydrochlorideCAS: 1246638-08-3纯度: >99.00%
An active metabolite of ivabradine
- GC33579Carvedilol metabolite 4-Hydroxyphenyl CarvedilolCAS: 142227-49-4
An active metabolite of carvedilol
- GC33602Decanoic acidCAS: 334-48-5纯度: >99.00% / >98.00%
Capric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.
- GC33606D-(+)-Glucono-1,5-lactone (Gluconic acid lactone)CAS: 90-80-2纯度: >99.00%
Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity.
- GC33607Hydrocinnamic acid (3-Phenyl-n-propionic acid)CAS: 501-52-0纯度: >99.50%
Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid) is a substrate of the enzyme oxidoreductases in the pathway phenylalanine metabolism (KEGG). It is an antifungal agent and a metabolite.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC33502 | 5,6-Dihydrouridine | 5627-05-4 | >99.50% | |
A pyrimidine nucleoside and derivative of uridine | ||||
| GC33504 | 4-Acetamidobutanoic acid (N-acetyl GABA) | 3025-96-5 | >98.00% | |
A GABA derivative | ||||
| GC33514 | 5-Methyluridine | 1463-10-1 | >98.50% | |
A pyrimidine nucleoside | ||||
| GC33518 | N-Acetylputrescine hydrochloride | 18233-70-0 | >95.00% / >98.00% | |
N-Acetylputrescinehydrochloride是一种腐胺衍生物。 | ||||
| GC33519 | 2,5-Dihydroxybenzoic acid | 490-79-9 | >99.50% | |
A benzoic acid with diverse biological activities | ||||
| GC33525 | 3-Methyluridine | 2140-69-4 | >98.00% | |
3-Methyluridine是细胞RNA的修饰核苷。 | ||||
| GC33526 | 5-Methylcytidine | 2140-61-6 | - | |
A modified nucleoside | ||||
| GC33532 | Norgestimate metabolite Norelgestromin (17-Deacetyl norgestimate) | 53016-31-2 | >99.50% | |
An active metabolite of norgestimate | ||||
| GC33548 | Netupitant metabolite Netupitant N-oxide (Netupitant N-oxide) | 910808-11-6 | - | |
A metabolite of netupitant | ||||
| GC33558 | Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) | 37519-14-5 | >99.50% / >98.00% | |
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen)是一种稳定的、羟基化的对乙酰氨基酚中间体。 | ||||
| GC33559 | Netupitant metabolite Monohydroxy Netupitant (Monohydroxy Netupitant) | 910808-12-7 | - | |
Monohydroxy Netupitant 是 Netupitant 的代谢物，Netupitant 是一种高选择性的 NK1 受体拮抗剂。 | ||||
| GC33563 | Netupitant metabolite N-desmethyl Netupitant (N-desmethyl Netupitant) | 290296-72-9 | - | |
N-desmethyl Netupitant 是 Netupitant 的代谢物，Netupitant 是一种止吐药。 | ||||
| GC33564 | Lurasidone metabolite 14326 | 186204-33-1 | - | |
An active metabolite of lurasidone | ||||
| GC33571 | Duloxetine metabolite Para-Naphthol Duloxetine (Para-Naphthol duloxetine) | 949095-98-1 | - | |
对萘酚度洛西汀是度洛西汀的代谢产物，度洛西汀是一种血清素去甲肾上腺素再摄取抑制剂 (SNRI)。 | ||||
| GC33578 | Ivabradine metabolite N-Demethyl Ivabradine hydrochloride | 1246638-08-3 | >99.00% | |
An active metabolite of ivabradine | ||||
| GC33579 | Carvedilol metabolite 4-Hydroxyphenyl Carvedilol | 142227-49-4 | - | |
An active metabolite of carvedilol | ||||
| GC33594 | Cytosine | 71-30-7 | >99.50% | |
A pyrimidine base | ||||
| GC33602 | Decanoic acid | 334-48-5 | >99.00% / >98.00% | |
Capric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt. | ||||
| GC33603 | Dihydrofolic acid | 4033-27-6 | >95.00% / >85.00% | |
An active metabolite of folic acid | ||||
| GC33604 | 3-Pyridineacetic acid | 501-81-5 | - | |
3-Pyridineaceticacid是尼克酸的高同系物，是尼古丁（和其它烟草生物碱）的分解产物。 | ||||
| GC33605 | 2'-Deoxyadenosine monohydrate | 16373-93-6 | >98.00% | |
A deoxyribonucleoside | ||||
| GC33606 | D-(+)-Glucono-1,5-lactone (Gluconic acid lactone) | 90-80-2 | >99.00% | |
Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity. | ||||
| GC33607 | Hydrocinnamic acid (3-Phenyl-n-propionic acid) | 501-52-0 | >99.50% | |
Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid) is a substrate of the enzyme oxidoreductases in the pathway phenylalanine metabolism (KEGG). It is an antifungal agent and a metabolite. | ||||
| GC33608 | Malic acid (E 296) | 6915-15-7 | >99.00% | |
The racemate of L-malic acid | ||||