Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC43453 Diflapolin
双黄素
A dual FLAP/sEH inhibitor
GC43444 Diclofenac Acyl-β-D-Glucuronide
双氯芬酸酰基-Β-D-葡糖苷酸
An active metabolite of diclofenac
GC43434 D-Glucose-6-phosphate (sodium salt)
D-葡萄糖-6-磷酸
D-Glucose-6-phosphate (sodium salt)是葡萄糖代谢的基本组成部分，是葡萄糖被己糖激酶（或葡萄糖激酶）磷酸化或葡萄糖-1-磷酸被磷酸葡糖变位酶转化时在细胞中形成的，这是糖原合成的第一步。
GC43432 D-Glucosamine-2-sulfate (sodium salt)
氨基葡萄糖硫酸钠盐
D-Glucosamine-2-sulfate（钠盐）是一种内源性代谢物。
GC43431 D-Fructose-6-phosphate (sodium salt)
D-果糖-6-磷酸二钠
D-Fructose-6-phosphate (sodium salt)是一种内源性代谢物，是糖酵解和磷酸戊糖途径的中间产物。
GC43423 Desmethylene Paroxetine (hydrochloride)
帕罗西汀杂质5
A major metabolite of the SSRI paroxetine
GC43422 Desmethyldoxepin (hydrochloride)
N-去甲盐酸多塞平,Desmethyldoxepin hydrochloride
The primary metabolite of doxepin
GC43419 Desmethyl Erlotinib
2-[[4-[(3-乙炔基苯基)氨基]-7-(2-甲氧基乙氧基)-6-喹唑啉基]氧基]乙醇,OSI-420 free base; CP-373420
A metabolite of erlotinib
GC43418 Desethylene Ciprofloxacin (hydrochloride)
脱乙烯环丙沙星盐酸盐
A major metabolite and degradation product of ciprofloxacin
GC43412 Desacetyl Bisacodyl
苉可硫酸钠杂质B
An active metabolite of the laxatives bisacodyl and sodium picosulfate
GC43403 Dehydroepiandrosterone Sulfate (sodium salt)
去氢表雄酮硫酸钠,Sodium prasterone sulfate
A steroid precursor
GC43401 Dehydro Nifedipine
4-(2硝基苯基)-2,6-二甲基吡啶-3,5二羧酸二甲酯
An active metabolite of nifedipine
GC43400 Dehydro Aripiprazole (hydrochloride)
脱氢阿立哌唑盐酸盐
The primary, active metabolite of aripiprazole
GC43393 Decanoyl-L-carnitine (chloride)
L-癸酰氯化肉碱
A derivative of L-carnitine
GC43376 Dapagliflozin-3-O-β-D-Glucuronide A metabolite of dapagliflozin
GC43371 Dabigatran Acyl-β-D-Glucuronide
达比加群酰基Β维葡糖苷酸
A major active metabolite of dabigatran
GC43367 D-(+)-Glucose-13C6
13C6-葡萄糖,Glucose-13C6; D-(+)-Glucose-13C6; Dextrose-13C6
D-(+)-Glucose-13C6是D-(+)-Glucose的稳定同位素标记对应物，主要用作定量 D-(+)-Glucose的内标，通过GC-或LC-MS测量。
GC43358 Cytochalasin A
细胞松弛素A
Inhibitor of actin polymerization
GC43355 Cytidine 5'-triphosphate (sodium salt)
三磷酸胞苷二钠,NSC 20261
Cytidine 5͇-三磷酸（钠盐）是一种内源性代谢物。
GC43345 Cyclohexanoyl Coenzyme A
CHCoA, Cyclohexanecarboxyl-CoA
An acyl CoA that contains a cyclohexane group
GC43343 Cyclo(L-Tyr-L-Val)
环(酪氨酸-缬氨酸)二肽,Cyclo(L-Tyr-L-Val)
A diketopiperazine fungal metabolite
GC43323 Creatine Phosphate (potassium salt)
Phosphocreatine

磷酸肌酸（钾盐）主要存在于脊椎动物的骨骼肌中，是一种称为 α 氨基酸和衍生物的有机化合物，是测定肌酸激酶的底物，用于在骨骼肌收缩过程中再生 ATP。
GC43297 Coenzyme Q2
辅酶Q2
A biosynthetic precursor to CoQ₁₀ and an inhibitor of mitochondrial complex I
GC43296 Coenzyme B12
腺苷钴胺; Coenzyme B12; Cobamamide; AdoCbl

A biologically active form of vitamin B12
GC43295 Coenzyme A (sodium salt hydrate)
CoA
An essential cofactor in enzymatic acetyl transfer reactions
GC43289 Cochlioquinone B A fungal metabolite
GC43285 CM037
A37
A selective inhibitor of ALDH1A1
GC43284 Clozapine N-oxide (hydrochloride)
CNO

A metabolite of clozapine and muscarinic DREADD agonist
GC43281 Clopidogrel Carboxylic Acid (hydrochloride)
(S)-(O-氯苯基)-6,7-二羟噻吩[3,2-C]吡啶-5(4H)-醋酸盐酸盐
A major inactive metabolite of clopidogrel
GC43278 Clindamycin Sulfoxide
克林霉素亚砜
An active metabolite of clindamycin
GC43261 Cholesteryl Myristate
胆固醇肉豆蔻酸; Cholesteryl myristate; Cholesteryl tetradecanoate
A cholesterol ester
GC43257 Cholesteryl Eicosapentaenoate
20:5 Cholesteryl ester
A cholesterol ester
GC43251 Cholesterol Sulfate (sodium salt)
胆固醇硫酸酯钠盐

硫酸胆固醇（Cholesterol Sulfate (sodium salt)) 于 1965 年首次从人体血浆中分离出来，浓度为 300 μg/100 ml 。
GC43248 Chlorzoxazone N-Glucuronide A phase II metabolite of chlorzoxazone
GC43225 Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide
塞来昔布羧酸酰基-Β-D-葡糖苷酸
A metabolite of celecoxib
GC43195 CAY10703 A stable dichloroacetate derivative
GC43194 CAY10698 A selective inhibitor of 12-LO
GC43192 CAY10685 A “clickable” analog of CPTH2
GC43188 CAY10680 A dual inhibitor of monoamine oxidase B and adenosine A_2A receptors
GC43154 CAY10443
(S)Indan1yl 3,4dichlorobenzylcarbamate
A cytochrome c-dependent inducer of apoptosis
GC43153 CAY10416 A dual COX-2/5-LO inhibitor
GC43146 Caspase-9 Inhibitor III (trifluoroacetate salt)
Ac-LEHD-CMK
A caspase-9 inhibitor
GC43144 Carfilzomib Impurity 13 (hydrochloride) A potential impurity found in commercial carfilzomib preparations
GC43141 Carboxyatractyloside (potassium salt)
羧基苍术苷
An inhibitor of ADP/ATP translocases
GC43140 Captopril Disulfide
卡托普利二硫化物,SQ 14551
A metabolite and degradation product of captopril
GC43114 Caffeic Acid-13C3 An internal standard for the quantification of caffeic acid
GC43069 C22 Ceramide (d18:1/22:0)
C22 Ceramide；Cer(d18:1/22:0)；Ceramide (d18:1/22:0)
C22 Ceramide (d18:1/22:0)是一种从海绵Haliclona koremella中分离的含有山萮酸的长链神经酰胺，是一种内源性生物活性鞘脂。
GC43052 C18 Phytoceramide (t18:0/18:0)
N-硬脂酰植物鞘胺醇
A bioactive sphingolipid
GC43051 C18 L-threo Ceramide (d18:1/18:0)
N-octadecanoyl-L-threo-Sphingosine, L-threo Cer(d18:1/18:0), L-threo Ceramide (d18:1/18:0)
A synthetic ceramide
GC43050 C18 L-erythro Ceramide (d18:1/18:0)
L-erythro Cer(d18:1/18:0), L-erythro Ceramide (d18:1/18:0), N-octadecanoyl-L-erythro-Sphingosine
A naturally occurring ceramide