Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) is stable and hydroxylated intermediate of acetaminophen [1]. Acetaminophen metabolite 3-hydroxy-acetaminophen is produced via hydroxyl radical addition to the ortho-position of paracetamol [2]. Acetaminophen metabolite 3-hydroxy-acetaminophen can be used as an internal reference to develop a high-performance liquid chromatography-ultraviolet detection method for analyzing the metabolites of acetaminophen in urine[3].
References:
[1] Salah W, Montes V, López-Tenllado F J, et al. Engineering Fe/Zn-doped TiO₂ semiconductors for solar driven selective conversion of acetaminophen into a functional bioactive intermediate[J]. Materials Science and Engineering: B, 2026, 327: 119237.
[2] Villota N, Lombraña J I, Cruz-Alcalde A, et al. Kinetic study of colored species formation during paracetamol removal from water in a semicontinuous ozonation contactor[J]. Science of the Total Environment, 2019, 649: 1434-1442.
[3] Wilson J M, Slattery J T, Forte A J, et al. Analysis of acetaminophen metabolites in urine by high-performance liquid chromatography with UV and amperometric detection[J]. Journal of Chromatography B: Biomedical Sciences and Applications, 1982, 227(2): 453-462.
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen)是一种稳定的、羟基化的对乙酰氨基酚中间体[1]。Acetaminophen metabolite 3-hydroxy-acetaminophen是通过羟自由基加成至对乙酰氨基酚的邻位而产生的[2]。Acetaminophen metabolite 3-hydroxy-acetaminophen可用作内参，以开发高效液相色谱-紫外检测法，用于分析尿液中乙酰氨基酚的代谢物[3]。