2'-Deoxyadenosine is a deoxyribonucleoside and an intermediate in the purine nucleotide degradation pathway.1 It is transported into cells via facilitated diffusion or formed within cells by degradation of S-adenosylhomocysteine or AMP and is removed from cells by purine metabolism or is converted into adenine nucleotides. 2'-Deoxyadenosine has been used in the characterization of DNA conformations and the synthesis of nucleoside analogs as antiviral agents.2,3
1.Fox, I.H., and Kelley, W.N.The role of adenosine and 2'-deoxyadenosine in mammalian cellsAnnu. Rev. Biochem.47655-686(1978) 2.Katahira, M., Nishimura, Y., Tsuboi, M., et al.Local and overall conformations of DNA double helices with the A - T base pairsBiochim. Biophys. Acta867(4)256-267(1986) 3.Ikejiri, M., Oshima, T., Fukushima, A., et al.Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agentsBioorg. Med. Chem. Lett.18(16)4638-4641(2008)