4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
The level of glutathione(GSH) in single erythrocytes is impacted slightly at low AAP(4-aminoantipyrine) concentrations probably due to the protection of glutathione reductase. When AAP concentration further increases, AAP has a significant influence on GSH[2].
4-aminoantipyrine (4-AA) is not genotoxic and mutagenic in vivo, it can interfere with DNA damaging agents biological activities and may reduce the effectiveness of DNA damage-based chemotherapy[3].
[1] Vinagre AM, et al. Braz J Med Biol Res. 2016, 49(3). [2] Teng Y, et al. J Hazard Mater. 2011, 192(3):1766-1771. [3] Berno CR, et al. Mutat Res Genet Toxicol Environ Mutagen. 2016, 805:19-24.