Regorafénib N-oxyde M2 is an active metabolite of Regorafenib[1-2]. Regorafénib N-oxyde M2 is primarily used for drug metabolism studies, exploration of kinase inhibitor mechanisms, and as a reference standard for analytical testing[3-4].
References:
[1] Kojima A, Sogabe A, Nadai M, et al. Species differences in oxidative metabolism of regorafenib. Xenobiotica. 2021 Dec;51(12):1400-1407.
[2] Zhu J, Zhong L, Song Y, et al. Exploring the effect of Wuzhi capsule on the pharmacokinetics of regorafenib and its main metabolites in rat plasma using liquid chromatography-tandem mass spectrometry. J Sep Sci. 2024 Mar;47(5):e2300923.
[3] Allard M, Khoudour N, Rousseau B, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.
[4] Fujita K, Taguchi D, Fukuda K, et al. Association between albumin-bilirubin grade and plasma trough concentrations of regorafenib and its metabolites M-2 and M-5 at steady-state in Japanese patients. Invest New Drugs. 2024 Jun;42(3):252-260.
Regorafénib N-oxyde M2是Regorafenib的一种活性代谢产物[1-2]。Regorafénib N-oxyde M2主要用于药物代谢研究、激酶抑制剂作用机制探索，以及作为分析检测的参考标准物[3-4]。