Coenzyme Q9 (Ubiquinone Q9)
(Synonyms: 辅酶Q9; Ubiquinone Q9; CoQ9; Ubiquinone 9) 目录号 : GC32470
一键复制产品信息
Coenzyme Q9 (Ubiquinone Q9)是一种具有9个异戊二烯单位的泛醌类化合物，作为电子传递链中的双亲分子组分，在内源性抗氧化和细胞能量代谢中发挥核心作用。
Cas No.:303-97-9
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
Coenzyme Q9 (Ubiquinone Q9) is a ubiquinone compound containing nine isoprene units. Coenzyme Q9 acts as a amphipathic component of the electron transport chain, playing a central role in endogenous antioxidant defense and cellular energy metabolism[1-2]. Coenzyme Q9 is the predominant form of ubiquinone in rodents, and Coenzyme Q9 is also normally present in human plasma, with corn oil being one of Coenzyme Q9 natural dietary sources. In research, Coenzyme Q9 is commonly employed to study mitochondrial dysfunction and related disease mechanisms[3-4].
In vivo, Coenzyme Q9 (supplemented in feed at 40mg/kg) was orally administered to broiler chickens subjected to cold stress (starting at 15 days of age and continuing until 21 days). Coenzyme Q9 significantly reduced the incidence of ascites and improved survival rate and production performance[5]. In guinea pigs, oral administration of Coenzyme Q9 (5mg/kg/day) for 4 weeks. Coenzyme Q9 significantly improved left ventricular function, reduced myocardial infarct area and apoptosis. The protective effect of Coenzyme Q9 was associated with its bioconversion to CoQ10[6].
References:
[1] Rodríguez-Aguilera JC, Asencio C, Ruiz-Ferrer M, et al. Caenorhabditis elegans ubiquinone biosynthesis genes. Biofactors. 2003;18(1-4):237-44.
[2] Ikeda S, Hamada N, Morii H, et al. Serum and tissue coenzyme Q9 in rats with thyroid dysfunctions. Horm Metab Res. 1984 Nov;16(11):585-8.
[3] Rodríguez-Acuña R, Brenne E, Lacoste F. Determination of coenzyme Q10 and Q9 in vegetable oils. J Agric Food Chem. 2008 Aug 13;56(15):6241-5.
[4] Battino M, Bompadre S, Leone L, et al. Coenzymes Q9 and Q10, vitamin E and peroxidation in rat synaptic and non-synaptic occipital cerebral cortex mitochondria during ageing. Biol Chem. 2001 Jun;382(6):925-31.
[5] Nakamura K, Noguchi K, Aoyama T, et al. Protective effect of ubiquinone (coenzyme Q9) on ascites in broiler chickens. Br Poult Sci. 1996 Mar;37(1):189-95.
[6] Lekli I, Das S, Das S, et al. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10. J Agric Food Chem. 2008 Jul 9;56(13):5331-7.
Coenzyme Q9 (Ubiquinone Q9)是一种具有9个异戊二烯单位的泛醌类化合物，作为电子传递链中的双亲分子组分，在内源性抗氧化和细胞能量代谢中发挥核心作用[1-2]。Coenzyme Q9是啮齿类动物中泛醌的主要形式，在人体血浆中也正常存在，玉米油是其天然膳食来源之一。Coenzyme Q9在研究中常用于线粒体功能异常及相关疾病机制的探索[3-4]。
在体内，Coenzyme Q9（以40mg/kg剂量添加于饲料中）口服处理冷应激诱导的肉鸡（从15日龄开始持续至21日龄），Coenzyme Q9显著降低腹水发生率，并提高生存率和生产性能[5]。Coenzyme Q9（5mg/kg/day）口服处理豚鼠（连续4周），Coenzyme Q9显著改善左心室功能，减少心肌梗死面积和细胞凋亡，Coenzyme Q9的保护作用与生物转化为CoQ10相关[6]。
| Animal experiment [1]: | |
Animal models | Hartley guinea pigs |
Preparation Method | Guinea pigs were orally administered a daily dose of Coenzyme Q9 (5mg/kg/day) for 4 weeks. After treatment, hearts were isolated and subjected to 30 minutes of global ischemia followed by 120 minutes of reperfusion. Cardiac function, arrhythmias, infarct size, and apoptosis were assessed. |
Dosage form | 5mg/kg/day; oral gavage; Daily administration for 4 weeks. |
Applications | Coenzyme Q9 administration provided significant cardioprotection against ischemia/reperfusion injury, improving left ventricular function, reducing ventricular arrhythmias, decreasing myocardial infarct size, and attenuating cardiomyocyte apoptosis. HPLC and mass spectrometry analysis revealed that CoQ9 was largely converted to CoQ10 in heart tissues. |
References: | |
| Cas No. | 303-97-9 | SDF | |
| 别名 | 辅酶Q9; Ubiquinone Q9; CoQ9; Ubiquinone 9 | ||
| Canonical SMILES | O=C1C(OC)=C(OC)C(C(C)=C1C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=O | ||
| 分子式 | C54H82O4 | 分子量 | 795.23 |
| 溶解度 | Ethanol:12.5mg/ml(15.72 mM); DMSO:2 mg/mL (2.51 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.2575 mL | 6.2875 mL | 12.575 mL |
| 5 mM | 251.5 μL | 1.2575 mL | 2.515 mL |
| 10 mM | 125.7 μL | 628.7 μL | 1.2575 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet