Coenzyme Q9 (Ubiquinone Q9) is a ubiquinone compound containing nine isoprene units. Coenzyme Q9 acts as a amphipathic component of the electron transport chain, playing a central role in endogenous antioxidant defense and cellular energy metabolism[1-2]. Coenzyme Q9 is the predominant form of ubiquinone in rodents, and Coenzyme Q9 is also normally present in human plasma, with corn oil being one of Coenzyme Q9 natural dietary sources. In research, Coenzyme Q9 is commonly employed to study mitochondrial dysfunction and related disease mechanisms[3-4].
In vivo, Coenzyme Q9 (supplemented in feed at 40mg/kg) was orally administered to broiler chickens subjected to cold stress (starting at 15 days of age and continuing until 21 days). Coenzyme Q9 significantly reduced the incidence of ascites and improved survival rate and production performance[5]. In guinea pigs, oral administration of Coenzyme Q9 (5mg/kg/day) for 4 weeks. Coenzyme Q9 significantly improved left ventricular function, reduced myocardial infarct area and apoptosis. The protective effect of Coenzyme Q9 was associated with its bioconversion to CoQ10[6].
References:
[1] Rodríguez-Aguilera JC, Asencio C, Ruiz-Ferrer M, et al. Caenorhabditis elegans ubiquinone biosynthesis genes. Biofactors. 2003;18(1-4):237-44.
[2] Ikeda S, Hamada N, Morii H, et al. Serum and tissue coenzyme Q9 in rats with thyroid dysfunctions. Horm Metab Res. 1984 Nov;16(11):585-8.
[3] Rodríguez-Acuña R, Brenne E, Lacoste F. Determination of coenzyme Q10 and Q9 in vegetable oils. J Agric Food Chem. 2008 Aug 13;56(15):6241-5.
[4] Battino M, Bompadre S, Leone L, et al. Coenzymes Q9 and Q10, vitamin E and peroxidation in rat synaptic and non-synaptic occipital cerebral cortex mitochondria during ageing. Biol Chem. 2001 Jun;382(6):925-31.
[5] Nakamura K, Noguchi K, Aoyama T, et al. Protective effect of ubiquinone (coenzyme Q9) on ascites in broiler chickens. Br Poult Sci. 1996 Mar;37(1):189-95.
[6] Lekli I, Das S, Das S, et al. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10. J Agric Food Chem. 2008 Jul 9;56(13):5331-7.
Coenzyme Q9 (Ubiquinone Q9)是一种具有9个异戊二烯单位的泛醌类化合物，作为电子传递链中的双亲分子组分，在内源性抗氧化和细胞能量代谢中发挥核心作用[1-2]。Coenzyme Q9是啮齿类动物中泛醌的主要形式，在人体血浆中也正常存在，玉米油是其天然膳食来源之一。Coenzyme Q9在研究中常用于线粒体功能异常及相关疾病机制的探索[3-4]。
在体内，Coenzyme Q9（以40mg/kg剂量添加于饲料中）口服处理冷应激诱导的肉鸡（从15日龄开始持续至21日龄），Coenzyme Q9显著降低腹水发生率，并提高生存率和生产性能[5]。Coenzyme Q9（5mg/kg/day）口服处理豚鼠（连续4周），Coenzyme Q9显著改善左心室功能，减少心肌梗死面积和细胞凋亡，Coenzyme Q9的保护作用与生物转化为CoQ10相关[6]。