Angiotensinogen (1-14), also known as tetradecapeptide (TDP), is a synthetic peptide precursor of angiotensin I that corresponds to amino acids 1-14 of endogenous human angiotensinogen.1 Angiotensinogen (1-14) is cleaved by renin at the Leu-Val peptide bond to release angiotensin I, which is then converted to angiotensin II by angiotensin converting enzyme (ACE) and exerts vasoconstrictive properties.2 Angiotensinogen (1-14) (0.001-1 μM) induces contraction of isolated rat femoral resistance vessels, an effect that is reduced by the angiotensin II receptor partial antagonist saralasin and enhanced by the serine protease kallikrein.3
1.Kageyama, R., Ohkubo, H., and Nakanishi, S.Primary structure of human preangiotensinogen deduced from the cloned cDNA sequenceBiochemistry23(16)3603-3609(1984) 2.Tewksbury, D.A., Dart, R.A., and Travis, J.The amino terminal amino acid sequence of human angiotensinogenBiochem. Biophys. Res. Commun.99(4)1311-1315(1981) 3.Kvist, S., Mulvany, M.J., and Aalkjaer, C.Studies of the renin-angiotensin system in the wall of rat femoral resistance vesselsEur. J. Pharmacol.198(1)77-83(1991)