(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 ?M).1 It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels.1 (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation.1
1.Petersen, D.N., Hawkins, J., Ruangsiriluk, W., et al.A small-molecule anti-secretagogue of PCSK9 targets the 80S ribosome to inhibit PCSK9 protein translationCell. Chem. Biol.231-10(2016)