(S)-Pro-xylane是一种具有生物活性的C-糖苷化合物，是化妆品中抗衰老配方的重要成分。
Cas No.:868156-46-1
Sample solution is provided at 25 µL, 10mM.
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(S)-Pro-xylane, a biologically active C-glycoside compound, is an important ingredient in antiaging skincare formulations in cosmetic products [1]. Through mimicking natural β-O-xylosides in skin, (S)-Pro-xylane is effective in stimulating the biosynthesis of glycosaminoglycans (GAGs), which leads to the preservation of matrix integrity and thereby contributes to skin's mechanical properties, such as elasticity and hydration [2]. (S)-Pro-xylane has been widely used to prevent the degradation and loss of glycosaminoglycans and proteoglycans in vivo[3].
In vitro, (S)-Pro-xylane treatment at 0.4mg/ml for 18h significantly enhanced the mRNA levels of collagen VII a1 and collagen IV a1 in normal human epidermal keratinocytes (NHKs), without affecting cell viability[4]. Treatment with 3mM (S)-Pro-xylane for 3 days increased syndecan 4 and perlecan levels in an ex vivo atrophic skin model[5].
In vivo, topical application of 100μl 1.5mg/ml (S)-Pro-xylane aqueous solution daily for 3 weeks significantly improved collagen loss and fiber breakage associated with skin aging, and reduced the degradation of elastic fibers associated with skin aging in Sprague-Dawley (SD) rats[6].
References:
[1] Zhao Y, Li Y, Shang J, et al. Engineering a Carbonyl Reductase for High-Efficiency Synthesis of Optically Pure (S)-Pro-Xylane: An Alternative Synthetic Route[J]. Journal of Agricultural and Food Chemistry, 2025, 73(16): 9759-9768.
[2] Dou Z, Hu P R, Song L L, et al. Extensive gene mining and facile engineering of a novel carbonyl reductase for asymmetric synthesis of anti-aging (S)-Pro-Xylane from d-xylose[J]. International Journal of Biological Macromolecules, 2025, 305: 140976.
[3] Lu J, Jiang Z, Xie X, et al. Efficient biosynthesis of Pro-Xylane through semi-rational engineering of carbonyl reductase from Canariomyces notabilis[J]. Molecular Catalysis, 2025, 579: 115020.
[4] Sok J, Pineau N, Dalko-Csiba M, et al. Improvement of the dermal epidermal junction in human reconstructed skin by a new c-xylopyranoside derivative[J]. European Journal of Dermatology, 2008, 18(3): 297-302.
[5] Pineau N, Bernerd F, Cavezza A, et al. A new C-xylopyranoside derivative induces skin expression of glycosaminoglycans and heparan sulphate proteoglycans[J]. European Journal of Dermatology, 2008, 18(1): 36-40.
[6] Yang A, Ma C, Song Q, et al. Anti-Aging Efficacy of Fructosazine and Deoxyfructosazine: A Comprehensive In Vitro and In Vivo Analysis[J]. Molecules, 2025, 30(11): 2263.
(S)-Pro-xylane是一种具有生物活性的C-糖苷化合物，是化妆品中抗衰老配方的重要成分[1]。(S)-Pro-xylane通过模拟皮肤中天然的β-木糖苷，有效刺激糖胺聚糖（GAGs）的生物合成，从而维持基质完整性，进而有助于改善皮肤的机械性能，如弹性和水合作用[2]。(S)-Pro-xylane已被广泛用于在体内防止糖胺聚糖和蛋白聚糖的降解和流失[3]。
在体外，使用0.4mg/ml的(S)-Pro-xylane处理18小时，显著提高了正常人表皮角质形成细胞(NHKs)中胶原蛋白VII a1和IV a1的mRNA水平，且不影响细胞活力[4]。使用3mM的(S)-Pro-xylane处理离体萎缩皮肤模型3天，增加了syndecan 4和perlecan的水平[5]。
在体内，每日局部涂抹100μl 1.5mg/ml的(S)-Pro-xylane水溶液，连续3周，显著改善了Sprague-Dawley大鼠与皮肤老化相关的胶原蛋白流失和纤维断裂，并减少了与皮肤老化相关的弹性纤维降解[6]。
| Cell experiment [1]: | |
Cell lines | Normal human dermal fibroblasts (NHDFs) |
Preparation Method | Normal human dermal fibroblasts (NHDFs) were cultured in DMEM medium supplemented with 10% fetal bovine serum, 1% penicillin-streptomycin and amphotericin B triple antibiotic solution. Cells were cultured in a 5% CO2 incubator at 37°C. Cells were treated with 0.4mg/ml of (S)-Pro-xylane for 18h and analyzed for cell viability and mRNA levels of collagen VII a1 and collagen IV a1. |
Reaction Conditions | 0.4mg/ml; 18h |
Applications | (S)-Pro-xylane treatment significantly enhanced the mRNA levels of collagen VII a1 and collagen IV a1, without affecting cell viability. |
| Animal experiment [2]: | |
Animal models | Male Sprague-Dawley rats |
Preparation Method | Male Sprague-Dawley rats were housed under controlled conditions (22±3°C, 12/12h light/dark cycle) and randomly assigned to experimental groups. Two skin areas, each measuring 2cm×2cm, were selected from the back of each rat, and the hair at the sampling sites was shaved. For each rat, one skin area was designated as the negative control, while the other was used as the (S)-Pro-xylane-treated group. The skin in the (S)-Pro-xylane-treated group was topically applied with 100μl 1.5mg/ml (S)-Pro-xylane aqueous solution (containing 10% propylene glycol) daily for 3 weeks. Rat skin morphology, collagen fibers, and elastic fibers were analyzed. |
Dosage form | 1.5mg/ml (100μl); Once a day for 3 weeks; topical application |
Applications | (S)-Pro-xylane treatment can improve the skin condition of rats, resulting in an increase in the content of collagen fibers and elastic fibers in the skin. |
References: | |
| Cas No. | 868156-46-1 | SDF | |
| 别名 | (S)-Hydroxypropyl tetrahydropyrantriol | ||
| Canonical SMILES | C[C@H](O)C[C@H](OC[C@H]1O)[C@@H]([C@H]1O)O | ||
| 分子式 | C8H16O5 | 分子量 | 192.21 |
| 溶解度 | DMSO: 250 mg/mL (1300.66 mM) | 储存条件 | 4°C, away from moisture and light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.2026 mL | 26.0132 mL | 52.0264 mL |
| 5 mM | 1.0405 mL | 5.2026 mL | 10.4053 mL |
| 10 mM | 520.3 μL | 2.6013 mL | 5.2026 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet