UAMC-3203 is an inhibitor of ferroptosis that has an IC50 value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells.1 It decreases iron-induced plasma lactate dehydrogenase (LDH) levels in a mouse model of acute iron poisoning when administered at a dose of 20 ?mol/kg. It is not toxic to mice following chronic administration of a 20 ?mol/kg dose for four weeks. UAMC-3203 has increased solubility and a longer half-life in mouse, rat, and human microsomes and isolated plasma than the ferroptosis inhibitor ferrostatin-1 . In an in silico membrane dynamics study, UAMC-3203 was incorporated into a phospholipid bilayer.
1.Devisscher, L., Van Coillie, S., Hofmans, S., et al.Discovery of novel, drug-like ferroptosis inhibitors with in vivo efficacyJ. Med. Chem.61(22)10126-10140(2018)