Ferroptosis(铁死亡)

Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.

Products for Ferroptosis

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Cat.No. 产品名称 Information
GC14049 (-)-Epigallocatechin gallate (EGCG)

(-)-表没食子儿茶素没食子酸酯,EGCG
(-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。
GC45248 (-)-FINO2 A ferroptosis inducer
GC34980 (E)-Ferulic acid

反式阿魏酸,(E)-Coniferic acid
Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.
GA11210 (H-Cys-OH)2

L-胱氨酸
(H-Cys-OH)2 是一种氨基酸和细胞内硫醇，在细胞过程的调节中起关键作用。
GC52290 (R)-HTS-3 An inhibitor of LPCAT3
GC46352 (S)-DO271 An inactive control for DO264
GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog
GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC

15(S)-HETE-SAPC, 15(S)-Hydroxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylcholine
An oxidized phospholipid
GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

15(S)-HETE-SAPE, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine

An oxidized phospholipid
GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11

15(S)-HETE-SAPE-d11, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE-d11, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d11
An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE
GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC

15(S)-HpETE-SAPC, 15(S)-Hydroperoxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Phosphatidylcholine

An oxidized phospholipid
GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine, 15(S)-HpETE-SAPE, 15(S)-hydroperoxyeicostetraenoic acid-SAPE

An oxidized phospholipid
GC62033 3α-Hydroxy pravastatin sodium

3Α-羟基普伐他汀钠
A metabolite of pravastatin
GC52413 5-Aminosalicylic Acid-d7

5-ASA-d7, Mesalamine-d7, Mesalazine-d7
An internal standard for the quantification of 5-aminosalicylic acid
GC68580 84-B10 84-B10 是一种 3-苯基戊二酸衍生物。84-B10 抑制 cisplatin 诱导的肾小管铁死亡。84-B10 减轻 cisplatin 诱导的线粒体损伤和氧化应激。84-B10 改善 cisplatin 诱导的急性肾损伤 (AKI)。
GC11786 Acetylcysteine

乙酰半胱氨酸; N-Acetylcysteine; N-Acetyl-L-cysteine; NAC
乙酰半胱氨酸是半胱氨酸的 N-乙酰基衍生物。
GC15130 Alogliptin (SYR-322)

阿格列汀; SYR-322 free base
Alogliptin (SYR-322) (SYR-322 free base) 是一种有效的、选择性的、具有口服活性的 DPP-4 抑制剂，IC50 <10 nM，选择性比 DPP-8 和 DPP-9 高 10,000 倍以上.
GC61895 Ammonium iron(III) citrate

柠檬酸铁 (III) 铵; Ammonium ferric citrate; FAC

Ammonium ferric citrate (Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz) induces ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity.
GC65163 Ardisiacrispin B

百两金皂苷B
Ardisiacrispin B是从传统中药植物紫金牛属植物中分离得到的天然三萜皂苷化合物。
GC35398 Arteannuin B

青蒿素B
A precursor to artemisinin with diverse biological activities
GC35399 Artefenomel

OZ439
An antimalarial agent
GN10647 Artemisinine

青蒿素; Qinghaosu; NSC 369397
Artemisinine是一种从青蒿植物（Artemisia annua）中提取的倍半萜内酯类抗疟药。
GC10889 Artesunate

青蒿琥酯
青蒿琥酯（Artesunate）是一种抗疟疾化合物，是信号转导及转录激活蛋白3（STAT-3）和膜谷胱甘肽S-转移酶（EXP1）的抑制剂。
GC14038 Atorvastatin Calcium

阿托伐他汀钙; CI-981; Atorvastatin hemicalcium
An HMG-CoA reductase inhibitor
GN10158 Baicalein

黄芩素; 5,6,7-Trihydroxyflavone
Baicalein（黄芩素；5，6，7-三羟基黄酮）是具有多种生物活性的黄酮类化合物，是黄嘌呤氧化酶抑制剂，IC₅₀值为3.12μM。
GC45820 Balsalazide-d4 Balsalazide-d4 是氘标记的 Balsalazide。
GC11572 Bardoxolone methyl

甲基巴多索隆; RTA 402; NSC 713200; CDDO Methyl ester
A synthetic triterpenoid with potent anticancer and antidiabetic activity
GC10345 Bay 11-7085

(2E)-3-[[4-叔丁基苯基]磺酰基]-2-丙烯腈,BAY 11-7083
An irreversible inhibitor of IκBα phosphorylation
GC12698 BAY 87-2243 A mitochondrial complex I inhibitor and inducer of ferroptosis
GC52317 BCP-T.A. A ferroptosis inducer
GC42928 BHT

2,6-二叔丁基对甲酚
A synthetic antioxidant
GC34070 Brusatol

鸦胆子苦醇; NSC 172924
Brusatol是一种Nrf2抑制剂，由从鸦嘴茅中分离提取。
GC74728 Butylated hydroxytoluene-d3

2,6-二叔丁基对甲酚-d3
Butylated hydroxytoluene-d3是氘标记的丁基化羟基甲苯。
GC30067 Butylhydroxyanisole (Butylated hydroxyanisole)

丁基羟基茴香醚; Butylated hydroxyanisole; BHA; E320
丁基羟基茴香醚（Butylated hydroxyanisole）（Butylated hydroxyanisole）是一种抗氧化剂，用作食品添加剂防腐剂。
GC91157 C18
一种共价的GPX4抑制剂
GC47065 CAY10773 A derivative of sorafenib
GC32723 CDDO-Im (RTA-403)

RTA-403; TP-235; CDDO-Imidazolide
An activator of Nrf2 signaling
GC20109 Cefotiam hexetil hydrochloride

盐酸头孢替安酯; CTM-HE hydrochloride; SCE-2174 hydrochloride

Cefotiam hexetil hydrochloride 是可口服的第三代头孢菌素，是 cefotiam 的前药，但无抗菌作用。Cefotiam 是一种抗生素。
GC43231 Cerivastatin (sodium salt)

西立伐他汀钠
An inhibitor of HMG-CoA reductase
GC45792 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

Iron Salophene Complex, N,N'-o-Phenylenebis(salicylideneaminato)iron(III) Chloride
An inducer of ferroptosis
GC35692 Chrysosplenetin

猫眼草黄素
A flavonoid with diverse biological activities
GC10132 Ciclopirox

环吡酮胺; HOE296b
An iron chelator, antifungal, and anticancer agent
GC11120 Ciclopirox ethanolamine

环吡酮乙醇胺盐; Ciclopirox ethanolamine; HOE 296
An iron chelator, antifungal, and anticancer agent
GC45764 Ciclopirox-d11 (sodium salt)

HOE 296b-d11
A neuropeptide with diverse biological activities
GC32237 CIL56

2,7-双(哌啶-1-基磺酰基)-9H-芴-9-酮肟,CA3
An inducer of non-apoptotic cell death
GC11908 Cisplatin

顺铂; cis-Platinum; CDDP; cis-Diaminodichloroplatinum
顺铂是最好的、最早的基于金属的化疗药物之一，用于治疗广泛的实体癌症，如睾丸癌、卵巢癌、膀胱癌、肺癌、宫颈癌、头颈部肿瘤和胃癌等。
GN10668 Coenzyme Q10

辅酶Q10; CoQ10; Ubiquinone-10
A cofactor in the electron transport chain
GC43297 Coenzyme Q2

辅酶Q2
A biosynthetic precursor to CoQ₁₀ and an inhibitor of mitochondrial complex I
GC49454 Complex 3 A fluorescent copper complex with anticancer activity
GC47123 Coumarin-Quinone Conjugate A fluorescent substrate for NADH:ubiquinone oxidoreductases