Ferroptosis(铁死亡)

Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.

Products for Ferroptosis

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Cat.No. 产品名称 Information
GC48954 CP21 An iron chelator
GC43329 Cu-ATSM

copper-ATSM, CuII(atsm)
A copper-containing compound with diverse biological activities
GC52164 Cu-ATSP

copper-ATSP, CuII(atsp)
A copper-containing bis(thiosemicarbazone) complex
GC14787 Curcumin

姜黄素; Diferuloylmethane; Natural Yellow 3; Turmeric yellow

A yellow pigment with diverse biological activities
GC40226 Curcumin-d6

(1E,4Z,6E)-5-羟基-1,7-二[4-羟基-3-(甲氧基-D3)苯基]-1,4,6-庚三烯-3-酮,Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6
An internal standard for the quantification of curcumin
GC10896 Cyclic Pifithrin-α hydrobromide

环状抑制剂-Α氢溴酸盐,Pifithrin-β
A stable inhibitor of p53
GC17198 Cycloheximide

Naramycin A; Actidione; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide
环己酰亚胺是一种抗生素，它在翻译水平上抑制蛋白质合成，仅对真核细胞的细胞质（80s）核糖体起作用。
GC33023 D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine)

丁基硫,Buthionine sulfoximine; BSO
A γ-glutamylcysteine synthetase inhibitor
GC35795 D,L-Buthionine-(S,R)-sulfoximine hydrochloride

Buthionine sulfoximine hydrochloride; BSO hydrochloride
A γ-glutamylcysteine synthetase inhibitor
GC49868 D-α-Tocopheryl Quinone

α-Tocopherylquinone
An oxidative metabolite of vitamin E
GC11835 Deferasirox

地拉罗司; ICL 670
Deferasirox是一种具口服活性的铁螯合剂，用于治疗铁过载疾病。
GC17412 Deferasirox Fe3+ chelate

地拉罗斯铁螯合物
Deferasirox Fe3+ Chelate 是从专利 WO2003053986 中提取的铁螯合剂。
GC18101 Deferiprone

去铁酮
An iron chelator
GC13554 Deferoxamine mesylate

甲磺酸去铁胺; Desferrioxamine B mesylate; DFOM
Deferoxamine mesylate 是一种通过形成稳定的复合物来螯合铁的药物，该复合物可防止铁进入进一步的化学反应，并用于治疗输血依赖性贫血患者的慢性铁过载。
GC38429 Dihydroartemisinic acid

双氢青蒿酸; Dihydroqinghao acid
A precursor to artemisinin
GC35876 DL-Glutamine

DL-谷氨酰胺; (±)-Glutamine; DL-Gl
DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.
GC45995 DO264 An ABHD12 inhibitor
GC31940 Docebenone (AA 861)

多西苯醌,AA 861

A 5-LO inhibitor
GC15399 Dp44mT

2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺
An iron chelator with antiproliferative effects
GC49058 DTPA

二乙烯三胺五醋酸,Diethylenetriaminepentaacetic acid; DTPA
A cell-impermeable metal chelating agent
GC48650 DTUN A lipophilic hyponitrite radical initiator
GC10331 Ebselen

依布硒; SPI-1005; PZ-51; CCG-39161
Ebselen一种具有谷胱甘肽过氧化物酶样活性的硒代有机化合物，是一种抗炎和抗氧化剂。Ebselen是肌醇单磷酸酶（IMPase）的抑制剂，IC₅₀为1.5μM。
GC16630 Erastin Erastin是一种能够穿透细胞膜的铁死亡激活剂和抗肿瘤药物，它选择性地作用于表达癌基因RAS的细胞。
GC43623 Erastin2

35MEW28
Erastin2 是一种有效的系统 xc 抑制剂和铁死亡诱导剂。
GC36011 Ethylenediaminetetraacetic acid trisodium salt

依地酸三钠盐; EDTA trisodium salt; Trisodium EDTA
Ethylenediaminetetraacetic acid (EDTA) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.
GC16517 Eugenol

丁香酚
丁香酚是一种存在于丁香中的精油，具有抗菌、驱虫和抗氧化活性。
GC91783 FA16 FA16 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.
GC91613 FerroLOXIN-1 FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.
GC91623 Ferroptosis Inducer 24 Ferroptosis inducer 24 is an inducer of ferroptosis.
GC91910 Ferroptosis Inhibitor D1 Ferroptosis Inhibitor D1是一种自由基清除剂和铁下垂抑制剂。
GC74018 Ferroptosis-IN-6 Ferroptosis-IN-6（化合物13）是一种有效的铁下垂抑制剂，EC50为25.5 nM。
GC10380 Ferrostatin-1 (Fer-1)

Fer-1
Ferrostatin-1是一种有效的铁死亡抑制剂，EC50为60纳摩尔。
GC40211 Ferrostatin-1 Diyne A ferroptosis inhibitor
GC13139 FG-4592 (ASP1517)

罗沙司他,Roxadustat
FG-4592 作为一种口服生物可利用的缺氧诱导因子 (HIF) 脯氨酰羟化酶抑制剂，可通过 HIF 介导的转录促进协调性红细胞生成。
GC30039 FIN56 FIN56 是一种新型的铁死亡诱导剂，它通过增加 GPX4 的降解来触发铁死亡。
GC15541 Fluvastatin Sodium

氟伐他汀钠,XU 62-320
An HMG-CoA reductase inhibitor
GC40228 Fluvastatin-d6 (sodium salt) An internal standard for the quantification of fluvastatin
GC90713 FSEN1

Ferroptosis Sensitizer 1

FSP1的抑制剂
GN10388 Gallic acid

没食子酸; 3,4,5-Trihydroxybenzoic acid
A phenol with diverse biological activities
GC61436 Gallic acid hydrate

没食子酸-水合物; 3,4,5-Trihydroxybenzoic acid hydrate
A phenol with diverse biological activities
GC11882 GKT137831

2-(2-氯苯基)-4-[3-(二甲基氨基)苯基]-5-甲基-1H-吡唑并[4,3-C]吡啶-3,6(2H,5H)-二酮,GKT137831; GKT831
GKT137831是一种口服有效的双重NADPH氧化酶1/4（NOX1/NOX4）抑制剂，活性处于亚微摩尔范围，可预防高糖诱导的人主动脉内皮细胞氧化应激，并减轻糖尿病小鼠的动脉粥样硬化进展。
GC41293 Glutathione ethyl ester

GSH-EE, GSH ethyl ester, GSH monoethyl ester
A cell-permeable derivative of glutathione
GC91598 GPX4 16

Glutathione Peroxidase 4 16
GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4).
GC90827 GPX4 24

Glutathione Peroxidase 4 24, PHGPx 24, Phospholipid Hydroperoxide Glutathione Peroxidase 24

一种GPX4抑制剂
GC92031 GPX4 Inhibitor 17

Glutathione Peroxidase 4-IN-17; Glutathione Peroxidase 4 Inhibitor 17; GPX4-IN-17
GPX4 Inhibitor 17是一种含二茂铁的谷胱甘肽过氧化物酶4 （GPX4）抑制剂和铁下垂诱导剂。
GC73589 GPX4-IN-6 GPX4-IN-6（化合物C25）是GPX4共价抑制剂，IC50值为0.13 μM。
GA10942 H-D-Gln-OH

D-谷氨酰胺
H-D-Gln-OH 是一种可渗透细胞的 D 型谷氨酰胺立体异构体。
GC72857 HBED HBED是一种强效的铁螯合剂。
GC14591 Hemin chloride

氯化血红素; Hemin chloride
氯化血红素是血红素加氧酶(HO)-1的底物，可诱导多种细胞表达HO-1，发挥抗氧化和抗炎作用。
GC15972 Idebenone

艾地苯醌
An analog of CoQ₁₀ with neuroprotective effects