Lumefantrine is an antimalarial drug that is used in combination with artemether .1 The pairing of lumefantrine and artemether is a major form of oral artemisinin combination therapy used against uncomplicated P. falciparum malaria.2,3 Lumefantrine also blocks the rapidly activating delayed-rectifier potassium channel (IKr; IC50 = 8.1 ?M).4
1.Pascual, A., Parola, P., Benoit-Vical, F., et al.Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparumMalar. J.11(2012) 2.Askling, H.H., Bruneel, F., Burchard, G., et al.Management of imported malaria in EuropeMalar. J.11(2012) 3.Mayxay, M., Khanthavong, M., Chanthongthip, O., et al.Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern LaosMalar. J.11184(2012) 4.Du, L.P., Tsai, K.C., Li, M.Y., et al.The pharmacophore hypotheses of IKr potassium channel blockers: Novel class III antiarrhythmic agentsBioorg. Med. Chem. Lett.14(18)4771-4777(2004)