DBCO-NHS ester is a crosslinker used to covalently attach DBCO groups to amine-containing molecules [1]. DBCO-NHS ester is commonly used for bioorthogonal labeling and molecular coupling in copper-free click chemistry [2-3].
References:
[1]. Hu B, Ji C, Zhou Z, et al. Bioorthogonal reaction-mediated photosensitizer–peptide conjugate anchoring on cell membranes for enhanced photodynamic therapy. Biomaterials Science. 2025.
[2]. Tan A, Liu Q, Septiadi D, et al. Understanding selectivity of metabolic labelling and click-targeting in multicellular environments as a route to tissue selective drug delivery. Journal of Materials Chemistry B. 2021 Jul 7; 9(26): 5365-5373.
[3]. Wiener J, Kokotek D, Rosowski S, et al. Preparation of single-and double-oligonucleotide antibody conjugates and their application for protein analytics. Scientific reports. 2020 Jan 29; 10(1): 1457.
DBCO-NHS ester是一种交联剂，用于将DBCO基团共价连接到含胺分子上 [1]。DBCO-NHS ester常用于无铜点击化学中的生物正交标记和分子偶联 [2-3]。