4',7-Di-O-methylnaringenin is a flavonoid aglycone that has been found in Vitex quinata and has potassium channel inhibitory and anticancer activities.1,2 It inhibits the voltage-gated potassium channel subtype Kv1.3 in a patch-clamp assay when used at a concentration of 30 ?M.1 4’,7-Di-O-methylnaringenin is cytotoxic to human LNCaP prostate, Lu1 lung, and MCF-7 breast cancer cells (EC50s = 6.7, 4.7, and 1.1 ?M, respectively).2
1.Teisseyre, A., Duarte, N., Ferreira, M.-J.U., et al.Influence of the multidrug transporter inhibitors on the activity of Kv1.3 voltage-gated potassium channelsJ. Physiol. Pharmacol.60(1)69-76(2009) 2.Deng, Y., Chin, Y.-W., Chai, H.-B., et al.Phytochemical and bioactivity studies on constituents of the leaves of Vitex quinataPhytochem. Lett.4(3)213-217(2011)