Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid)

Adrenic acid is a naturally occurring polyunsaturated fatty acid (PUFA) formed through a 2-carbon chain elongation of arachidonic acid. It is present in the adrenal glands, brain, testis, and kidney.¹ Although there is trace metabolism of adrenic acid in the forebrain, the renal medulla is the only tissue which readily metabolizes the acid through cyclooxygenase activity.^1,2 The primary metabolite of adrenic acid in the rabbit kidney is 1a,1b-dihomo prostaglandin E₂.¹

1.Sprecher, H., VanRollins, M., Sun, F., et al.Dihomo-prostaglandins and -thromboxane. A prostaglandin family from adrenic acid that may be preferentially synthesized in the kidneyJ. Biol. Chem.257(7)3912-3918(1982) 2.Ferretti, A., and Flanagan, V.P.Mass spectrometric evidence for the conversion of exogenous adrenate to dihomo-prostaglandins by seminal vesicle cyclo-oxygenase. A comparative study of two animal speciesJ. Chromatogr.383(2)241-250(1986)